Zobrazeno 1 - 10
of 46
pro vyhledávání: '"InAh Hwang"'
Autor:
Joo-Young Im, Soo Jin Kim, Jong-Lyul Park, Tae-Hee Han, Woo-il Kim, Inhyub Kim, Bomin Ko, So-Young Chun, Mi-Jung Kang, Bo-Kyung Kim, Sol A. Jeon, Seon-Kyu Kim, Incheol Ryu, Seon-Young Kim, Ki-Hoan Nam, Inah Hwang, Hyun Seung Ban, Misun Won
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 1, Pp 235-249 (2024)
Abstract Cytochrome b5 reductase 3 (CYB5R3) is involved in various cellular metabolic processes, including fatty acid synthesis and drug metabolism. However, the role of CYB5R3 in cancer development remains poorly understood. Here, we show that CYB5R
Externí odkaz:
https://doaj.org/article/0b08a891f6e7484ead7d40b35e5ac83c
Autor:
Fei Li, Yizhe Wang, Inah Hwang, Ja-Young Jang, Libo Xu, Zhong Deng, Eun Young Yu, Yiming Cai, Caizhi Wu, Zhenbo Han, Yu-Han Huang, Xiangao Huang, Ling Zhang, Jun Yao, Neal F. Lue, Paul M. Lieberman, Haoqiang Ying, Jihye Paik, Hongwu Zheng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Alternative lengthening of telomeres (ALT) provides cancer cells a mechanism to sustain replicative immortality. Here, the authors identify KDM2A as a molecular vulnerability in ALT-dependent cancer cells and demonstrate its role in the resolution of
Externí odkaz:
https://doaj.org/article/94cf5acf3ae146119f45347a657f708e
Autor:
Ja-Young Jang, Inah Hwang, Heng Pan, Jun Yao, Lapo Alinari, Eddie Imada, Claudio Zanettini, Michael J. Kluk, Yizhe Wang, Yunkyoung Lee, Hua V. Lin, Xiangao Huang, Maurizio Di Liberto, Zhengming Chen, Karla V. Ballman, Lewis C. Cantley, Luigi Marchionni, Giorgio Inghirami, Olivier Elemento, Robert A. Baiocchi, Selina Chen-Kiang, Sandro Belvedere, Hongwu Zheng, Jihye Paik
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
Targeting lineage-defined transcriptional dependencies has emerged as an effective therapeutic strategy in cancer treatment. Through screening for molecular vulnerabilities of mantle cell lymphoma (MCL), we identified a set of transcription factors (
Externí odkaz:
https://doaj.org/article/e15c9cf4b48849f098c33b46bf6b5433
Autor:
Inah Hwang, Hiroki Uchida, Ziwei Dai, Fei Li, Teresa Sanchez, Jason W. Locasale, Lewis C. Cantley, Hongwu Zheng, Jihye Paik
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Neural stem and progenitor cells (NSPCs) encounter constant stresses during aging, such as elevated oxidative stress. Here the authors show that oxidative stress induced reduction in NSPC neural differentiation is mediated by a FOXO3-GNMT/SAM-lamin-c
Externí odkaz:
https://doaj.org/article/ca30ad5f34a0473993a7b4f89ef269d0
Autor:
Inah Hwang, Dongqing Cao, Yoonmi Na, Do-Yeon Kim, Tuo Zhang, Jun Yao, Hwanhee Oh, Jian Hu, Hongwu Zheng, Yu Yao, Jihye Paik
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1208-1221 (2018)
Summary: Loss of a cell's ability to terminally differentiate because of mutations is a selected genetic event in tumorigenesis. Genomic analyses of low-grade glioma have reported recurrent mutations of far upstream element-binding protein 1 (FUBP1).
Externí odkaz:
https://doaj.org/article/4e423018e97c4727a9a9633391e9c4b9
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
Macrophages are important components of adipose tissue inflammation, which results in metabolic diseases such as insulin resistance. Notably, obesity induces a proinflammatory phenotypic switch in adipose tissue macrophages, and oxidative stress faci
Externí odkaz:
https://doaj.org/article/59c79c8776b240ebabe0720dfba21fe3
Publikováno v:
The Journal of General Education. 20:87-119
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b9ed0ce8c99ded6cec1c904fff18d32
https://doi.org/10.24173/jge.2022.07.20.4
https://doi.org/10.24173/jge.2022.07.20.4
Autor:
Misun Won, Joo-Young Im, Soo Jin Kim, Jong-Lyul Park, Tae-Hee Han, Woo-il Kim, Inhyub Kim, Bomin Ko, So-Young Chun, Mi-Jung Kang, Bo-Kyung Kim, Sol A Jeon, Seon-Kyu Kim, Incheol Ryu, Seon-Young Kim, Inah Hwang, Hyun Seung Ban
Cytochrome b5 reductase 3 (CYB5R3) is involved in various cellular metabolic processes, including fatty acid synthesis and drug metabolism. However, the role of CYB5R3 in cancer development remains poorly understood. Here, we show that CYB5R3 express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b16abccb698f16eb4130562fcf38982c
https://doi.org/10.21203/rs.3.rs-2810245/v1
https://doi.org/10.21203/rs.3.rs-2810245/v1
Publikováno v:
Free Radic Biol Med
Neural stem/progenitor cells (NSPCs) contribute to the physiological cellular turnover of the adult brain and make up its regenerative potential. It is thus essential to understand how different factors influence their proliferation and differentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21aee06f7ed741b9594e39f52de69d21
https://doi.org/10.1016/j.freeradbiomed.2021.03.043
https://doi.org/10.1016/j.freeradbiomed.2021.03.043
Autor:
Jun Yao, Inah Hwang, Hongwu Zheng, J. Li, Qianghu Wang, Lingxiang Wu, Baoli Hu, Dongqing Cao, Ja Young Jang, Haoqiang Ying, Yu Yao, Hwanhee Oh, Jihye Paik
Publikováno v:
Cancer Research. 81:1528-1539
EGFR is frequently amplified, mutated, and overexpressed in malignant gliomas. Yet the EGFR-targeted therapies have thus far produced only marginal clinical responses, and the underlying mechanism remains poorly understood. Using an inducible oncogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a74431800f9b32761b0fb61c267b37f
https://doi.org/10.1158/0008-5472.can-20-1810
https://doi.org/10.1158/0008-5472.can-20-1810