Zobrazeno 1 - 10
of 2 199
pro vyhledávání: '"In-vitro differentiation"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The generation of iPSC-derived hepatocyte-like cells (HLCs) is a powerful tool for studying liver diseases, their therapy as well as drug development. iPSC-derived disease models benefit from their diverse origin of patients, enabling the study of di
Externí odkaz:
https://doaj.org/article/37f1b8af35204c5394ffd74cbb512d35
Autor:
In-Won Lee, Hyeon-Geun Lee, Dae-Ky Moon, Yeon-Ji Lee, Bo-Gyeong Seo, Sang-Ki Baek, Tae-Suk Kim, Cheol Hwangbo, Joon-Hee Lee
Publikováno v:
Journal of Animal Reproduction and Biotechnology, Vol 38, Iss 3, Pp 109-120 (2023)
Background: Pluripotent stem cells (PSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) offer the immense therapeutic potential in stem cell-based therapy of degenerative disorders. However, clinical trials of human
Externí odkaz:
https://doaj.org/article/f35587af051c4201b7b6cf68a681d51b
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8449 (2024)
A thorough characterization of induced pluripotent stem cells (iPSCs) used with in vitro models or therapeutics is essential. Even iPSCs derived from a single donor can exhibit variability within and between cell lines, which can lead to heterogeneit
Externí odkaz:
https://doaj.org/article/5a77547595b4412986af675662249ff7
Publikováno v:
BioImpacts, Vol 13, Iss 4, Pp 289-300 (2023)
Introduction: Pluripotent stem cells have been used by various researchers to differentiate and characterize endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) for the clinical treatment of vascular injuries. Studies continue to differe
Externí odkaz:
https://doaj.org/article/dc181bf70843440ebf962f0e3fc12ed9
Autor:
Roberta Schellino, Dario Besusso, Roberta Parolisi, Gabriela B. Gómez-González, Sveva Dallere, Linda Scaramuzza, Marta Ribodino, Ilaria Campus, Paola Conforti, Malin Parmar, Marina Boido, Elena Cattaneo, Annalisa Buffo
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Background Huntington’s disease (HD) is a motor and cognitive neurodegenerative disorder due to prominent loss of striatal medium spiny neurons (MSNs). Cell replacement using human embryonic stem cells (hESCs) derivatives may offer new the
Externí odkaz:
https://doaj.org/article/f71569f50089476dbb34ca55c6b023b8
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4926 (2024)
Gonadotoxic agents could impair spermatogenesis and may lead to male infertility. The present study aimed to evaluate the effect of IL-1β on the development of spermatogenesis from cells isolated from seminiferous tubules (STs) of normal and busulfa
Externí odkaz:
https://doaj.org/article/3ad21bdf4c9f4961ad67c5015b3e6410
Autor:
Ahmed Salama, Emad Tolba, Ahmed K. Saleh, Iriczalli Cruz-Maya, Marco A. Alvarez-Perez, Vincenzo Guarino
Publikováno v:
Biomimetics, Vol 9, Iss 4, p 253 (2024)
In recent years, polyelectrolytes have been successfully used as an alternative to non-collagenous proteins to promote interfibrillar biomineralization, to reproduce the spatial intercalation of mineral phases among collagen fibrils, and to design bi
Externí odkaz:
https://doaj.org/article/c8793072d0b846c9afb9e3733beed035
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Disruptions of SETBP1 (SET binding protein 1) on 18q12.3 by heterozygous gene deletion or loss-of-function variants cause SETBP1 disorder. Clinical features are frequently associated with moderate to severe intellectual disability
Externí odkaz:
https://doaj.org/article/9f18ceb82edc4d70ad9e05fbb7316ea1
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Mammalian female reproduction requires a functional ovary. Competence of the ovary is determined by the quality of its basic unit–ovarian follicles. A normal follicle consists of an oocyte enclosed within ovarian follicular cells. In humans and mic
Externí odkaz:
https://doaj.org/article/6c2100a1a34246e09721399ed9981b4b
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2160 (2024)
Spermatogenesis is the process of proliferation and differentiation of spermatogonial cells to meiotic and post-meiotic stages and sperm generation. Normal spermatogenesis occurs in vivo at 34 °C to 35 °C, and high temperatures are known to cause m
Externí odkaz:
https://doaj.org/article/bd9647c6aab04d33a85c2472a7dd11a1