Zobrazeno 1 - 10
of 22 433
pro vyhledávání: '"In-Hyun Park"'
Autor:
Mehmet H. Kural, Umidahan Djakbarova, Bilal Cakir, Yoshiaki Tanaka, Emily T. Chan, Valeria I. Arteaga Muniz, Yasaman Madraki, Hong Qian, Jinkyu Park, Lorenzo R. Sewanan, In-Hyun Park, Laura E. Niklason, Comert Kural
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)
Abstract The transmembrane death receptor Fas transduces apoptotic signals upon binding its ligand, FasL. Although Fas is highly expressed in cancer cells, insufficient cell surface Fas expression desensitizes cancer cells to Fas-induced apoptosis. H
Externí odkaz:
https://doaj.org/article/544a7a26c62646bdaf6e0dc321de4417
Autor:
Sean P. Harrison, Richard Siller, Yoshiaki Tanaka, Maria Eugenia Chollet, María Eugenia de la Morena-Barrio, Yangfei Xiang, Benjamin Patterson, Elisabeth Andersen, Carlos Bravo-Pérez, Henning Kempf, Kathrine S. Åsrud, Oleg Lunov, Alexandr Dejneka, Marie-Christine Mowinckel, Benedicte Stavik, Per Morten Sandset, Espen Melum, Saphira Baumgarten, Flavio Bonanini, Dorota Kurek, Santosh Mathapati, Runar Almaas, Kulbhushan Sharma, Steven R. Wilson, Frøydis S. Skottvoll, Ida C. Boger, Inger Lise Bogen, Tuula A. Nyman, Jun Jie Wu, Ales Bezrouk, Dana Cizkova, Javier Corral, Jaroslav Mokry, Robert Zweigerdt, In-Hyun Park, Gareth J. Sullivan
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 9, Pp 2005-2024 (2023)
Abstract The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoid models have been developed for a number of tissues, including the liver. Current
Externí odkaz:
https://doaj.org/article/807e8461f64a4203a1ae380b8b984277
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The diencephalon, an integral component of the forebrain, governs a spectrum of crucial functions, ranging from sensory processing to emotional regulation. Yet, unraveling its unique development, intricate connectivity, and its role in neurodevelopme
Externí odkaz:
https://doaj.org/article/2bf01c51cb804df0b4cff99622f24bc8
Autor:
Woo Sub Yang, In-Hyun Park
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S48- (2023)
Externí odkaz:
https://doaj.org/article/08da7169d76448c199f4fea7d6533993
Autor:
Haifeng Zhang, Busu Li, Qunhua Huang, Francesc López-Giráldez, Yoshiaki Tanaka, Qun Lin, Sameet Mehta, Guilin Wang, Morven Graham, Xinran Liu, In-Hyun Park, Anne Eichmann, Wang Min, Jenny Huanjiao Zhou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
The role of mitochondrial activity in angiogenesis is not entirely understood. Here, the authors show that mitochondria as a signaling hub and their dysfunction causes augmented TGFβ signaling to induce retinal sprouting retardation and vascular mal
Externí odkaz:
https://doaj.org/article/6643fa837afc47fdabb599a2f3a02651
Autor:
Bilal Cakir, Yoshiaki Tanaka, Ferdi Ridvan Kiral, Yangfei Xiang, Onur Dagliyan, Juan Wang, Maria Lee, Allison M. Greaney, Woo Sub Yang, Catherine duBoulay, Mehmet Hamdi Kural, Benjamin Patterson, Mei Zhong, Jonghun Kim, Yalai Bai, Wang Min, Laura E. Niklason, Prabir Patra, In-Hyun Park
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The study of human microglia function in health and disease is limited by the availability of sound models. Here, the authors develop a method to generate functional microglia in human cortical organoids and investigate the role of human microglia du
Externí odkaz:
https://doaj.org/article/f7e442e71a714aed94079c5c43728648
Autor:
Jialin Sun, Sivan Osenberg, Austin Irwin, Li-Hua Ma, Nigel Lee, Yangfei Xiang, Feng Li, Ying-Wooi Wan, In-Hyun Park, Mirjana Maletic-Savatic, Nurit Ballas
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111942- (2023)
Summary: Mutations in the MECP2 gene underlie a spectrum of neurodevelopmental disorders, most commonly Rett syndrome (RTT). We ask whether MECP2 mutations interfere with human astrocyte developmental maturation, thereby affecting their ability to su
Externí odkaz:
https://doaj.org/article/1fbbe2c170cb467c877ec479802254ec
Autor:
Yolpanhchana Lim, Jennifer E. Beane-Ebel, Yoshiaki Tanaka, Boting Ning, Christopher R. Husted, David C. Henderson, Yangfei Xiang, In-Hyun Park, Lindsay A. Farrer, Huiping Zhang
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Transcriptomic changes in specific brain regions can influence the risk of alcohol use disorder (AUD), but the underlying mechanism is not fully understood. We investigated AUD-associated miRNA–mRNA regulatory networks in multiple brain re
Externí odkaz:
https://doaj.org/article/e74b2297dd6e42a391971ab49712c1fb
Dyslexia associated gene KIAA0319 regulates cell cycle during human neuroepithelial cell development
Autor:
Steven Paniagua, Bilal Cakir, Yue Hu, Ferdi Ridvan Kiral, Yoshiaki Tanaka, Yangfei Xiang, Benjamin Patterson, Jeffrey R. Gruen, In-Hyun Park
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Dyslexia, also known as reading disability, is defined as difficulty processing written language in individuals with normal intellectual capacity and educational opportunity. The prevalence of dyslexia is between 5 and 17%, and the heritability range
Externí odkaz:
https://doaj.org/article/a2589f321b944831a25bd115505eeb24
Autor:
Bilal Cakir, In-Hyun Park
Publikováno v:
eLife, Vol 11 (2022)
Fusing brain organoids with blood vessel organoids leads to the incorporation of non-neural endothelial cells and microglia into the brain organoids.
Externí odkaz:
https://doaj.org/article/0b5ca0d445b340d18d767ce28b5ff597