Zobrazeno 1 - 10
of 858
pro vyhledávání: '"In-Hyuk Jung"'
Autor:
Paul C. Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H. Burks, Junedh Amrute, Jared S. Elenbaas, Chul Joo Kang, Erica P. Young, Philipp E. Scherer, Nathan O. Stitziel
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110104- (2024)
Summary: Coronary artery disease (CAD) remains a leading cause of disease burden globally, and there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic colocalization analyses can help identify novel therapeutic
Externí odkaz:
https://doaj.org/article/f1c5ae12bdf0423691d81d9943e37603
Autor:
Kendall H. Burks, Yan Xie, Michael Gildea, In-Hyuk Jung, Sandip Mukherjee, Paul Lee, Upasana Pudupakkam, Ryan Wagoner, Ved Patel, Katherine Santana, Arturo Alisio, Ira J. Goldberg, Brian N. Finck, Edward A. Fisher, Nicholas O. Davidson, Nathan O. Stitziel
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100500- (2024)
Angiopoietin-like protein 3 (ANGPTL3) is a hepatically secreted protein and therapeutic target for reducing plasma triglyceride-rich lipoproteins and low-density lipoprotein (LDL) cholesterol. Although ANGPTL3 modulates the metabolism of circulating
Externí odkaz:
https://doaj.org/article/0bbb8760625945f68aa390901c0e6cd2
Autor:
In-Hyuk Jung, Nathan O. Stitziel
Publikováno v:
Heliyon, Vol 10, Iss 4, Pp e25760- (2024)
Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an extracellular matrix protein that causally promotes cardiovascular disease in humans and mice. However, the receptor mediating the effect of SVEP1 on the develop
Externí odkaz:
https://doaj.org/article/58733af23ef14f5f8e569dcdbd40db90
Autor:
Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola, Nathan O. Stitziel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
SVEP1 is linked to numerous human diseases, though its disease-promoting mechanism has remained unclear. Here, the authors identify SVEP1 as a ligand for the orphan receptor PEAR1 and provide insight into the role of this interaction in cardiovascula
Externí odkaz:
https://doaj.org/article/00a5662500fa4216a282bb3c8ddfa931
Autor:
Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola, Nathan O. Stitziel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/7c4ce03f276947c5a06906eedf5397a8
The Janis-Newman-Winicour (JNW) spacetime possesses a naked singularity, although it represents an exact particle-like solution to the Einstein-Klein-Gordon theory with a massless scalar field. Here, we investigate the possible formation of a naked s
Externí odkaz:
http://arxiv.org/abs/2408.03016
Autor:
Se-Jin Jeong, Min Ji Cho, Na Young Ko, Sinai Kim, In-Hyuk Jung, Jeong-Ki Min, Sang Hak Lee, Jong-Gil Park, Goo Taeg Oh
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1587-1601 (2020)
Abdominal aortic aneurysm: Potential enzyme biomarker identified An enzyme with antioxidant properties may provide a biomarker and therapeutic agent to help treat abdominal aortic aneurysm (AAA). AAA involves the structural deterioration of the aorta
Externí odkaz:
https://doaj.org/article/ac150413adfa4232b9ac9ef7b0bb429e
Autor:
Jing Jin, In-Hyuk Jung, Shin Hye Moon, Sejin Jeon, Se-Jin Jeong, Seong-Keun Sonn, Seungwoon Seo, Mi-Ni Lee, Eun Ju Song, Hyae Yon Kweon, Sinai Kim, Tae Kyeong Kim, Juyang Kim, Hong Rae Cho, Jae-Hoon Choi, Byungsuk Kwon, Goo Taeg Oh
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4124-4136.e5 (2020)
Summary: CD137, a potent costimulatory receptor for CD8+ T cells, is expressed in various non-T cells, but little is known about its regulatory functions in these cells. In this study, we show that CD137 signaling, specifically in intestinal CD11b−
Externí odkaz:
https://doaj.org/article/b3c398b186994245969e3a371b486a34
Autor:
Goh, Chul Jun1 (AUTHOR) cj.ko@edgc.com, Kwon, Hyuk-Jung1,2 (AUTHOR) hjkwon@edgc.com, Kim, Yoonhee1 (AUTHOR) yh.kim@edgc.com, Jung, Seunghee1 (AUTHOR) sh.jung@edgc.com, Park, Jiwoo1 (AUTHOR) jw.park@edgc.com, Lee, Isaac Kise1,2,3 (AUTHOR) ks.lee@edgc.com, Park, Bo-Ram1 (AUTHOR) br.park@edgc.com, Kim, Myeong-Ji1 (AUTHOR) myeongji.kim@edgc.com, Kim, Min-Jeong4 (AUTHOR) mjkim@diagnomics.com, Lee, Min-Seob1,4 (AUTHOR) mlee@edgc.com
Publikováno v:
Diagnostics (2075-4418). Jan2024, Vol. 14 Issue 1, p84. 16p.
Autor:
Jae-Seung Yun, Sang-Hyuk Jung, Manu Shivakumar, Brenda Xiao, Amit V. Khera, Hong-Hee Won, Dokyoon Kim
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Background Few studies have examined associations between genetic risk for type 2 diabetes (T2D), lifestyle, clinical risk factors, and cardiovascular disease (CVD). We aimed to investigate the association of and potential interactions among
Externí odkaz:
https://doaj.org/article/73e788d15b10429dbda623e219670bd5