Zobrazeno 1 - 10
of 1 198
pro vyhledávání: '"In-Hwan Baek"'
Autor:
Seon-Kwang Lee, Eun-Sol Ha, Heejun Park, Kyu-Tae Kang, Ji-Su Jeong, Jeong-Soo Kim, In-hwan Baek, Min-Soo Kim
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2704 (2023)
In this study, an amorphous solid dispersion containing the poorly water-soluble drug, bisacodyl, was prepared by hot-melt extrusion to enhance its therapeutic efficacy. First, the miscibility and interaction between the drug and polymer were investi
Externí odkaz:
https://doaj.org/article/b43364c40a8e453d9a89c6247158fc7c
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1446 (2022)
Propafenone (PPF) is a class 1C antiarrhythmic agent mainly metabolized by cytochrome (CYP) 2D6, CYP1A2, and CYP3A4. Previous studies have shown that CYP2D6 polymorphism influences the pharmacokinetics (PK) of PPF. However, the small sample sizes of
Externí odkaz:
https://doaj.org/article/ef9ee42fe42049c1a5fefc7ff0229501
Autor:
Won-ho Kang, Jae-yeon Lee, Jung-woo Chae, Kyeong-Ryoon Lee, In-hwan Baek, Min-Soo Kim, Hyun-moon Back, Sangkeun Jung, Craig Shaffer, Rada Savic, Hwi-yeol Yun
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 114 (2021)
Sample sizes for single-period clinical trials, including pharmacokinetic studies, are statistically determined by within-subject variability (WSV). However, it is difficult to determine WSV without replicate-designed clinical trial data, and statist
Externí odkaz:
https://doaj.org/article/8616252597634ab59a550a02c6d48520
Publikováno v:
Antioxidants, Vol 10, Iss 1, p 90 (2021)
In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol. Solid-state characterization of amorphous solid dispersions of trans-res
Externí odkaz:
https://doaj.org/article/2d447f5d18474fb1ac4c614935c3dba0
Autor:
Eun-Sol Ha, Heejun Park, Seon-Kwang Lee, Woo-Yong Sim, Ji-Su Jeong, In-hwan Baek, Min-Soo Kim
Publikováno v:
Antioxidants, Vol 9, Iss 4, p 342 (2020)
The aim of this study was to prepare pure trans-resveratrol nanoparticles without additives (surfactants, polymers, and sugars) using a supercritical antisolvent (SAS) process with alcohol (methanol or ethanol) and dichloromethane mixtures. In additi
Externí odkaz:
https://doaj.org/article/fc1a2bda6e3b4678aac01703d30ce8c8
Autor:
Heejun Park, Kwang-Ho Cha, Seung Hyeon Hong, Sharif Md Abuzar, Seungyeol Lee, Eun-Sol Ha, Jeong-Soo Kim, In-Hwan Baek, Min-Soo Kim, Sung-Joo Hwang
Publikováno v:
Pharmaceutics, Vol 12, Iss 4, p 333 (2020)
Orlistat, an anti-obesity drug, has two critical issues—the first is its low efficacy due to low water solubility and the second is side effects such as oily spotting due to its lipase inhibition. The present study was designed to propose a solutio
Externí odkaz:
https://doaj.org/article/9dece2e01b9d4e4aa21ee5ea89e1f3f1
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 9496-9509 (2015)
The present study aimed to investigate the effect of Eudragit® E/HCl (E-SD) on the degradation of sirolimus in simulated gastric fluid (pH 1.2) and to develop a new oral formulation of sirolimus using E-SD solid dispersions to enhance oral bioavaila
Externí odkaz:
https://doaj.org/article/262d406a7fc54c4cb68e3b0ed974f382
Publikováno v:
Molecules, Vol 19, Iss 12, Pp 20325-20339 (2014)
The aim of this study was to develop celecoxib-polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process. The effect of different surfactants such as gelucire 44/14, poloxa
Externí odkaz:
https://doaj.org/article/0a21225a551c48a9b278a0b1f3a4627d
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 187 (2018)
Tadalafil is an oral selective phosphodiesterase type-5 inhibitor with demonstrated efficacy and safety that is used to treat erectile dysfunction. The purpose of this study is to compare the pharmacokinetic properties of tadalafil after conventional
Externí odkaz:
https://doaj.org/article/d2d3bda74305419f834c0c10a442aae4
Autor:
Seunghyun Lee, Dong Jae Shim, Doyoung Kim, Soo Buem Cho, Seung Hwan Baek, Lee, Edward Wolfgang, Jung Whee Lee
Publikováno v:
Korean Journal of Radiology; Nov2024, Vol. 25 Issue 11, p1011-1021, 11p