Adapting the Scar-in-a-Jar to Skin Fibrosis and Screening Traditional and Contemporary Anti-Fibrotic Therapies

Autor: João Q. Coentro, Ulrike May, Stuart Prince, John Zwaagstra, Olli Ritvos, Tero A.H. Järvinen, Dimitrios I. Zeugolis

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)

Skin fibrosis still constitutes an unmet clinical need. Although pharmacological strategies are at the forefront of scientific and technological research and innovation, their clinical translation is hindered by the poor predictive capacity of the cu

Externí odkaz: https://doaj.org/article/9be38f6fa9d5457292ea2f41b898a06f

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Current challenges and future perspectives in oral absorption research : an opinion of the UNGAP network

Autor: Saskia N. de Wildt, Patrick Augustijns, Anette Müllertz, Mark McAllister, Cordula Stillhart, Brendan T. Griffin, James Butler, Kateřina Valentová, Andreas Bernkop-Schnürch, Nigel Davies, Caitriona M. O'Driscoll, Christos Reppas, Hannah Batchelor, Clive G. Wilson, Filippos Kesisoglou, Mirko Koziolek, Maria Vertzoni, Alan R. Mackie, Bertil Abrahamsson, Christopher J.H. Porter, Kiyohiko Sugano, Jadwiga Paszkowska, Zahari Vinarov, Didier Dupont, Martin Kuentz, Nikoletta Fotaki, Janneke Keemink, Jens Ceulemans, Petr Pavek, Gøril Eide Flaten, Elena Toader, Per Artursson, Vincent Jannin, Philippe Berben, Neil Parrott, Antonio J. Meléndez-Martínez

Publikováno v: Advanced Drug Delivery Reviews, 171, 289-331
Advanced Drug Delivery Reviews
Advanced Drug Delivery Reviews, Elsevier, 2021, 171, pp.289-331. ⟨10.1016/j.addr.2021.02.001⟩
Vinarov, Z, Abrahamsson, B, Artursson, P, Batchelor, H, Berben, P, Bernkop-Schnurch, A, Butler, J, Ceulemans, J, Davies, N, Dupont, D, Flaten, G E, Fotaki, N, Griffin, B T, Jannin, V, Keemink, J, Kesisoglou, F, Koziolek, M, Kuentz, M, Mackie, A, Melendez-Martinez, A J, McAllister, M, Mullertz, A, O'Driscoll, C M, Parrott, N, Paszkowska, J, Pavek, P, Porter, C J H, Reppas, C, Stillhart, C, Sugano, K, Toader, E, Valentova, K, Vertzoni, M, De Wildt, S N, Wilson, C G & Augustijns, P 2021, ' Current challenges and future perspectives in oral absorption research : An opinion of the UNGAP network ', Advanced Drug Delivery Reviews, vol. 171, pp. 289-331 . https://doi.org/10.1016/j.addr.2021.02.001
Advanced Drug Delivery Reviews, 171, pp. 289-331

Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33eec6da8069c781165c09e0bfc8b4fe
https://strathprints.strath.ac.uk/75801/1/Vinarov_etal_ADDR_2021_Current_challenges_and_future_perspectives_in_oral_absorption_research.pdf

Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates:Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools

Autor: Laura J. Henze, Joseph P. O'Shea, Jacob Rune Jørgensen, Niklas J. Koehl, Harriet Bennett-Lenane, Anette Müllertz, Brendan T. Griffin

Publikováno v: Bennett-Lenane, H, Jørgensen, J R, Koehl, N J, Henze, L J, O'Shea, J P, Müllertz, A & Griffin, B T 2021, ' Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates : Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools ', European Journal of Pharmaceutical Sciences, vol. 161, 105778 . https://doi.org/10.1016/j.ejps.2021.105778

Validation and characterisation of in vitro and pre-clinical animal models to support bio-enabling formulation development is of paramount importance. In this work, post-mortem gastric and small intestinal fluids were collected in the fasted, fed sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fb52694411d08daffa803bad79c3bc
https://curis.ku.dk/ws/files/263034089/1_s2.0_S0928098721000804_main.pdf

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