Zobrazeno 1 - 10 of 37 pro vyhledávání: '"In vitro liver models"'
1
Akademický článek
Optimization of extracellular matrix for primary human hepatocyte cultures using mixed collagen-matrigel matrices
Autor: Lena Seidemann, Sarah Prinz, Jan-Constantin Scherbel, Christina Götz, Daniel Seehofer, Georg Damm
Publikováno v: EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 12-34 (2023)
Loss of differentiation of primary human hepatocytes (PHHs) ex vivo is a known problem of in vitro liver models. Culture optimizations using collagen type I and Matrigel reduce the dedifferentiation process but are not able to prevent it. While neith
Externí odkaz: https://doaj.org/article/5f95ff161ca144f4a00a505c7521d57a
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2
Akademický článek
Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver
Autor: Samantha V. Llewellyn, Gillian E. Conway, Ilaria Zanoni, Amalie Kofoed Jørgensen, Ume-Kulsoom Shah, Didem Ag Seleci, Johannes G. Keller, Jeong Won Kim, Wendel Wohlleben, Keld Alstrup Jensen, Anna Costa, Gareth J. S. Jenkins, Martin J. D. Clift, Shareen H. Doak
Publikováno v: Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-24 (2021)
Abstract Background With the continued integration of engineered nanomaterials (ENMs) into everyday applications, it is important to understand their potential for inducing adverse human health effects. However, standard in vitro hazard characterisat
Externí odkaz: https://doaj.org/article/a7986442632e40378669f55646113773
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3
Akademický článek
Liver Cell Models in in Vitro Toxicology
Autor: Guillouzo, André
Publikováno v: Environmental Health Perspectives, 1998 Apr 01. 106, 511-532.
Externí odkaz: https://www.jstor.org/stable/3433803
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4
Optimization of extracellular matrix for primary human hepatocyte cultures using mixed collagen-matrigel matrices
Autor: Seidemann, Lena, Prinz, Sarah, Scherbel, Jan-Constantin, Götz, Christina, Seehofer, Daniel, Damm, Georg
Loss of differentiation of primary human hepatocytes (PHHs) ex vivo is a known problem of in vitro liver models. Culture optimizations using collagen type I and Matrigel reduce the dedifferentiation process but are not able to prevent it. While neith
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bc6f307eb43d3df8fc1236ea0f397f
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5
Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver
Autor: Anna Luisa Costa, Johannes Keller, Wendel Wohlleben, Gareth J.S. Jenkins, Ume-Kulsoom Shah, Jeong Won Kim, Keld Alstrup Jensen, Samantha V. Llewellyn, Martin J. D. Clift, Didem Ag Seleci, Shareen H. Doak, Gillian E. Conway, Amalie Kofoed Jørgensen, Ilaria Zanoni
Publikováno v: Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-24 (2021)
Journal of Nanobiotechnology
Background With the continued integration of engineered nanomaterials (ENMs) into everyday applications, it is important to understand their potential for inducing adverse human health effects. However, standard in vitro hazard characterisation appro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b53c9862987c5b53aa9fd3c93d886c
https://doaj.org/article/a7986442632e40378669f55646113773
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6
Akademický článek
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7
Next generation in vitro liver model design: Combining a permeable polystyrene membrane with a transdifferentiated cell line
Autor: Luetchford, Kim A., Wung, Nelly, Argyle, Iain S., Storm, Michael P., Weston, Stephen D., Tosh, David, Ellis, Marianne J.
Publikováno v: Journal of Membrane Science
Herein we describe the manufacture and characterisation of biocompatible, porous polystyrene membranes, suitable for cell culture. Though widely used in traditional cell culture, polystyrene has not been used as a hollow fibre membrane due to its hyd
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09a9b177f3c1f44178ade65f0597c46e
http://europepmc.org/articles/PMC6148409
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8
Akademický článek
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9
In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment
Autor: Marije Niemeijer, Gareth J.S. Jenkins, Shareen H. Doak, Penny Nymark, Martijn J Moné, Bob van de Water, Samantha V. Llewellyn, Gillian E. Conway
Publikováno v: Small, 17(15)
Small
Whilst the liver possesses the ability to repair and restore sections of damaged tissue following acute injury, prolonged exposure to engineered nanomaterials (ENM) may induce repetitive injury leading to chronic liver disease. Screening ENM cytotoxi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c75f9e3c82711ece87d641c9548085d
https://doi.org/10.1002/smll.202006055
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10
Akademický článek
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