Zobrazeno 1 - 10
of 4 658
pro vyhledávání: '"In vitro in vivo"'
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-23 (2024)
Abstract The merging of physiology and toxicokinetics, or pharmacokinetics, with computational modeling to characterize dosimetry has led to major advances for both the chemical and pharmaceutical research arenas. Driven by the mutual need to estimat
Externí odkaz:
https://doaj.org/article/d51b5f3019944a8da521a483167d657f
Publikováno v:
Nano Biomedicine and Engineering, Vol 16, Iss 3, Pp 429-442 (2024)
Proniosomes are drug-encapsulated, nanoscale vesicular structures that generate multilamellar niosomal dispersions upon hydration. This study aimed to develop enalapril maleate nanoproniosomal gels and assess their effectiveness in experimental hyper
Externí odkaz:
https://doaj.org/article/0d866edcba1247d3b20c270b0dd63b88
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-10 (2024)
Abstract Oxidative damage to human retinal pigment epithelial (RPE) cells is the main cause of age-related macular degeneration (AMD), in our previous work, we showed that ghrelin has an antioxidative effect on human lens epithelium (HLE) cells, howe
Externí odkaz:
https://doaj.org/article/76deacdfbe2d48d8a7c90d0e2f71d323
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 1, Pp 132-142 (2024)
Abstract Delayed‐release and extended‐release methylphenidate hydrochloride (JORNAY PM®) is a novel capsule formulation of methylphenidate hydrochloride, used to treat attention deficit hyperactivity disorder in patients 6 years and older. In th
Externí odkaz:
https://doaj.org/article/52b4d8aecf41422caf7dc7daf960fbf8
Autor:
Alessandro Boianelli, Pär Nordell, Joseph Earl, Jacqueline Naylor, David Hornigold, Rasmus Jansson Löfmark, Monika Sundqvist
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1310 (2024)
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) play an important role in the treatment of type 2 diabetes (T2D) and obesity. The relationship between efficacy and dosing regimen has been studied extensively for this class of molecul
Externí odkaz:
https://doaj.org/article/bc3368e2f4524eb2b6cacea2fc7c70c5
Autor:
Shuwen Jiang, Xiangkun Li, Weifang Xue, Sumei Xia, Jian Wang, Yang Sai, Guangxiu Dai, Weiguo Su
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Amdizalisib, also named HMPL-689, a novel selective and potent PI3Kδ inhibitor, is currently under Phase II clinical development in China for treating hematological malignancies. The preclinical pharmacokinetics (PK) of amdizalisib were extensively
Externí odkaz:
https://doaj.org/article/171a0dd993234a97b37b3479bb05b230
Autor:
Saniya Jawed, C. S. Satish
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Background The current research aims to determine the pharmacokinetic parameters, mucoadhesive strength, and IVIVC correlation of the novel chronotherapeutic drug delivery system of montelukast sodium (MTS) loaded Parteck® SRP80 and hyprome
Externí odkaz:
https://doaj.org/article/33d9057328e74f1d85a790284308c959
Publikováno v:
Farmacja Polska, Vol 79, Iss 6, Pp 319-328 (2023)
The biopharmaceutical classification system, proposed in 1995 by Amidon in order to facilitate dissolution studies and to correlate their results with the bioavailability of a drug substance in vivo has been successfully used for almost 30 years in p
Externí odkaz:
https://doaj.org/article/e38c1caae15b4b25bf473f4dd9612570
Autor:
David M. Crizer, Julie R. Rice, Marci G. Smeltz, Katelyn S. Lavrich, Krishna Ravindra, John F. Wambaugh, Michael DeVito, Barbara A. Wetmore
Publikováno v:
Toxics, Vol 12, Iss 9, p 672 (2024)
Toxicokinetic (TK) assays and in vitro–in vivo extrapolation (IVIVE) models are New Approach Methods (NAMs) used to translate in vitro points of departure to exposure estimates required to reach equivalent blood concentrations. Per- and polyfluoroa
Externí odkaz:
https://doaj.org/article/e1bcf9fb3f204f5fa7c8aeeeb7b6bb27
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 896 (2024)
The interest in the development and therapeutic application of long-acting injectable products for chronic or long-term treatments has experienced exponential growth in recent decades. TV-46000 (Uzedy, Teva) is a long-acting subcutaneous (sc) injecta
Externí odkaz:
https://doaj.org/article/e6298492b68d4b7592574b3b7f693b17