REPLY TO MA AND WANG : Reliability of various in vitro activity assays on SARS-CoV-2main protease inhibitors

Autor: Li, Zhe, Lin, Yuxi, Huang, Yi-You, Liu, Runduo, Zhan, Chang-Guo, Wang, Xin, Luo, Hai-Bin

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2021 Feb . 118(8), 1-2.

Externí odkaz: https://www.jstor.org/stable/27006303

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Synthesis of bis-furyl-pyrrolo[3,4-b]pyridin-5-ones via Ugi–Zhu reaction and in vitro activity assays against human SARS-CoV-2 and in silico studies on its main proteins

Autor: Ivette Morales-Salazar, Flora P. Montes-Enríquez, Carlos E. Garduño-Albino, M. A. García-Sánchez, Ilich A. Ibarra, Yareli Rojas-Aguirre, Montserrat Elemi García-Hernández, Rosa Elena Sarmiento-Silva, Sofía Lizeth Alcaraz-Estrada, Erik Díaz-Cervantes, Eduardo González-Zamora, Alejandro Islas-Jácome

Publikováno v: RSC Medicinal Chemistry. 14:154-165

Six polyheterocycles were studied in vitro against human SARS-CoV-2 finding that one of them exhibited significant activity at initial infection stages, showing prophylactic potential. A second one showed both, prophylactic and therapeutic activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::212470d466ff6fccd9a3b3f8516d6ee6
https://doi.org/10.1039/d2md00350c

Reply to Ma and Wang: Reliability of various in vitro activity assays on SARS-CoV-2 main protease inhibitors.

Autor: Li Z; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, 510006 Guangzhou, People's Republic of China., Lin Y; Center for Innovative Marine Drug Screening & Evaluation, School of Medicine and Pharmacy, Ocean University of China, 266100 Qingdao, China.; School of Life Sciences, Lanzhou University, 734000 Lanzhou, China., Huang YY; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, 510006 Guangzhou, People's Republic of China., Liu R; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, 510006 Guangzhou, People's Republic of China., Zhan CG; Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, Lexington, KY 40536; zhan@uky.edu wx8399@ouc.edu.cn luohb77@mail.sysu.edu.cn.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536., Wang X; Center for Innovative Marine Drug Screening & Evaluation, School of Medicine and Pharmacy, Ocean University of China, 266100 Qingdao, China; zhan@uky.edu wx8399@ouc.edu.cn luohb77@mail.sysu.edu.cn.; Marine Biomedical Research Institute of Qingdao, 266100 Qingdao, China., Luo HB; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, 510006 Guangzhou, People's Republic of China; zhan@uky.edu wx8399@ouc.edu.cn luohb77@mail.sysu.edu.cn.; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Pharmaceutical Sciences, Hainan University, 570228 Haikou, China.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Feb 23; Vol. 118 (8).

In vitro Activity Assays to Quantitatively Assess the Endogenous Reversible Oxidation State of Protein Tyrosine Phosphatases in Cells

Autor: Benoit Boivin, Syed Husain Mustafa Rizvi, Avinash D. Londhe

Publikováno v: Curr Protoc Chem Biol

The reversible oxidation of protein tyrosine phosphatases (PTPs) impairs their ability to dephosphorylate substrates in vivo. This transient inactivation of PTPs occurs as their conserved catalytic cysteine residue reacts with cellular oxidants there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97668c403c575b1a13ca27cedf9525d7
https://europepmc.org/articles/PMC7493824/