Zobrazeno 1 - 10
of 188
pro vyhledávání: '"In silico trials"'
Autor:
Avisa Maleki, Elena Crispino, Serena Anna Italia, Valentina Di Salvatore, Maria Assunta Chiacchio, Fianne Sips, Roberta Bursi, Giulia Russo, Davide Maimone, Francesco Pappalardo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3081-3090 (2023)
Multiple sclerosis is an autoimmune inflammatory disease that affects the central nervous system through chronic demyelination and loss of oligodendrocytes. Since the relapsing-remitting form is the most prevalent, relapse-reducing therapies are a pr
Externí odkaz:
https://doaj.org/article/ba08fa880ed64faeb056e96e943b35f2
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 22, Iss S6, Pp 1-10 (2022)
Abstract Background The last few decades have seen the approval of many new treatment options for Relapsing-Remitting Multiple Sclerosis (RRMS), as well as advances in diagnostic methodology and criteria. These developments have greatly improved the
Externí odkaz:
https://doaj.org/article/cae1a307b2ee4a4698c7853fa835de46
Akademický článek
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Akademický článek
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Publikováno v:
BMC Bioinformatics, Vol 22, Iss S14, Pp 1-20 (2022)
Abstract Background Nowadays, the inception of computer modeling and simulation in life science is a matter of fact. This is one of the reasons why regulatory authorities are open in considering in silico trials evidence for the assessment of safenes
Externí odkaz:
https://doaj.org/article/0f8a23f04dfd42baa4827bf60da4689d
Autor:
Giulia Russo, Elena Crispino, Emanuela Corsini, Martina Iulini, Alicia Paini, Andrew Worth, Francesco Pappalardo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6172-6181 (2022)
In many domains regulating chemicals and chemical products, there is a legal requirement to determine skin sensitivity to allergens. While many in vitro assays to detect contact hypersensitivity have been developed as alternatives to animal testing o
Externí odkaz:
https://doaj.org/article/b601ddda47c84b5da6bd1a03ee32c972
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1764-1777 (2022)
Immunotoxicity hazard identification of chemicals aims to evaluate the potential for unintended effects of chemical exposure on the immune system. Perfluorinated alkylate substances (PFAS), such as perfluorooctane sulfonate (PFOS) and perfluorooctano
Externí odkaz:
https://doaj.org/article/4ab36813fa884879be6c785f8b6354f6
Autor:
Sara Bridio, Giulia Luraghi, Anna Ramella, Jose Felix Rodriguez Matas, Gabriele Dubini, Claudio A. Luisi, Michael Neidlin, Praneeta Konduri, Nerea Arrarte Terreros, Henk A. Marquering, Charles B. L. M. Majoie, Francesco Migliavacca
Publikováno v:
Applied Sciences, Vol 13, Iss 18, p 10074 (2023)
The development of in silico trials based on high-fidelity simulations of clinical procedures requires the availability of large cohorts of three-dimensional (3D) patient-specific anatomy models, which are often hard to collect due to limited availab
Externí odkaz:
https://doaj.org/article/86129865bee94941853da685b86edfcd
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
The preclinical identification of drug-induced cardiotoxicity and its translation into human risk are still major challenges in pharmaceutical drug discovery. The ICH S7B Guideline and Q&A on Clinical and Nonclinical Evaluation of QT/QTc Interval Pro
Externí odkaz:
https://doaj.org/article/51480fe6bfe54fbd80a1a0a0cdb1b93d
Publikováno v:
Bioengineering, Vol 10, Iss 6, p 737 (2023)
Backgrounds and Objective: Facial palsy is a complex pathophysiological condition affecting the personal and professional lives of the involved patients. Sudden muscle weakness or paralysis needs to be rehabilitated to recover a symmetric and express
Externí odkaz:
https://doaj.org/article/c3a6d2578ee944bbb783554cb2d4ccd7