Zobrazeno 1 - 10
of 5 206
pro vyhledávání: '"In Vitro Toxicology"'
Autor:
Andrea Balogh, Mária Bódi-Jakus, Vivien Réka Karl, Tamás Bellák, Balázs Széky, János Farkas, Federica Lamberto, David Novak, Anita Fehér, Melinda Zana, András Dinnyés
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract In the present study, we aimed to establish and characterize a mature cortical spheroid model system for Kleefstra syndrome (KS) using patient-derived iPSC. We identified key differences in the growth behavior of KS spheroids determined by r
Externí odkaz:
https://doaj.org/article/06195f2e86214261b189325dc26c9d8d
Autor:
Bernarda Majc, Anamarija Habič, Marta Malavolta, Miloš Vittori, Andrej Porčnik, Roman Bošnjak, Jernej Mlakar, Alenka Matjašič, Andrej Zupan, Marija Skoblar Vidmar, Tamara Lah Turnšek, Aleksander Sadikov, Barbara Breznik, Metka Novak
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110604- (2024)
Summary: Glioblastoma (GB) is the most common primary malignant brain tumor, characterized by resistance to therapy. Despite aggressive treatment options, GB remains an incurable disease. Invasiveness and heterogeneity are key GB features that cannot
Externí odkaz:
https://doaj.org/article/2811208931514fd98a2e14598552201e
Autor:
V. N. Perfilova
Publikováno v:
Безопасность и риск фармакотерапии, Vol 12, Iss 1, Pp 68-82 (2024)
SCIENTIFIC RELEVANCE. The Tox21 (Toxicology in the 21st Century) programme was developed by the US Tox21 Consortium with the aim to replace animal-based toxicity assessments of chemicals with a wide range of in vitro and in silico testing approaches
Externí odkaz:
https://doaj.org/article/18d026ce55954adbac2530fd9ad64345
Autor:
Mitchell R. McGill, Yihong Kaufmann, Francesca V. LoBianco, Mary A. Schleiff, Nukhet Aykin-Burns, Grover P. Miller
Publikováno v:
Livers, Vol 3, Iss 2, Pp 310-321 (2023)
Tyrosine kinase inhibitors (TKIs) are increasingly popular drugs used to treat more than a dozen different diseases including some forms of cancer. Despite having fewer adverse effects than traditional chemotherapies, they are not without risks. Live
Externí odkaz:
https://doaj.org/article/cb87a53173f0461394b2908ac863a3c6
Autor:
Sherri Bloch, Laura Lévêque, Irva Hertz-Picciotto, Birgit Puschner, Ellen Fritsche, Jördis Klose, Nynke I. Kramer, Maryse F. Bouchard, P. Charukeshi Chandrasekera, Marc-André Verner
Publikováno v:
Environment International, Vol 183, Iss , Pp 108411- (2024)
Background: Current acceptable chemical exposure levels (e.g., tolerable daily intake) are mainly based on animal experiments, which are costly, time-consuming, considered non-ethical by many, and may poorly predict adverse outcomes in humans. Object
Externí odkaz:
https://doaj.org/article/3c281d7386a04c87b32276cbe2a80b81
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5133 (2024)
The main focus of in vitro toxicity assessment methods is to assess the viability of the cells, which is usually based on metabolism changes. Yet, when exposed to toxic substances, the cell triggers multiple signals in response. With this in mind, we
Externí odkaz:
https://doaj.org/article/56c582ce8cb84d508c5d2f7cd12863db
Autor:
Zhou Yang, Xiyi Wei, Chengjian Ji, Xiaohan Ren, Wei Su, Yichun Wang, Jingwan Zhou, Zheng Zhao, Pengcheng Zhou, Kejie Zhao, Bing Yao, Ninghong Song, Chao Qin
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108148- (2023)
Summary: O-GlcNAc transferase (OGT) acts in the development of various cancers, but its role in clear cell renal cell carcinoma (ccRCC) remains unclear. In this study, we found that OGT was upregulated in ccRCC and this upregulation was associated wi
Externí odkaz:
https://doaj.org/article/16639bd3c1994becb2c88430fbe1a87a
Autor:
Mari Spildrejorde, Athina Samara, Ankush Sharma, Magnus Leithaug, Martin Falck, Stefania Modafferi, Arvind Y.M. Sundaram, Ganesh Acharya, Hedvig Nordeng, Ragnhild Eskeland, Kristina Gervin, Robert Lyle
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107755- (2023)
Summary: Prenatal paracetamol exposure has been associated with neurodevelopmental outcomes in childhood. Pharmacoepigenetic studies show differences in cord blood DNA methylation between unexposed and paracetamol-exposed neonates, however, causality
Externí odkaz:
https://doaj.org/article/eaa93903bd90460f99f82e7ebc62ccaa
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