Zobrazeno 1 - 10
of 627
pro vyhledávání: '"In Sook Song"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Solute carrier family (SLC) transporters are expressed in the digestive system and play important roles in maintaining physiological functions in the body. In addition, SLC transporters act as oncoproteins or tumor-suppressor proteins during
Externí odkaz:
https://doaj.org/article/53aee8e4dc754114b78e9041f5e1d900
Publikováno v:
APL Bioengineering, Vol 8, Iss 1, Pp 010902-010902-8 (2024)
Organoids significantly advanced our comprehension of organ development, function, and disease modeling. This Perspective underscores the potential of heart–kidney-connected organoids in understanding the intricate relationship between these vital
Externí odkaz:
https://doaj.org/article/1da884ff628749aab85dccc0bdc6a758
Publikováno v:
BMC Neuroscience, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Several phosphodiesterase 4 (PDE4) inhibitors have emerged as potential therapeutics for central nervous system (CNS) diseases. This study investigated the pharmacological effects of two selective PDE4 inhibitors, roflumilast and
Externí odkaz:
https://doaj.org/article/4b7d62c2fa5d4890b4ef50d769a9434b
Autor:
Ji-Hyeon Jeon, So-Yeon Jeon, Yeon-Ju Baek, Chan-E Park, Min-Koo Choi, Young Taek Han, Im-Sook Song
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 934 (2024)
The quinoline alkaloid 2-(quinoline-8-carboxamido)benzoic acid (2-QBA), which is isolated from Aspergillus sp. SCSIO06786, a deep sea-derived fungus, has been suggested as a therapeutic candidate for the treatment of Parkinson’s disease. We develop
Externí odkaz:
https://doaj.org/article/6a34bbe9da6948b8bdbc83f8a76f1479
Autor:
Min Seo Lee, Jihoon Lee, Minyoung Pang, John Kim, Hyunju Cha, Banyoon Cheon, Min-Koo Choi, Im-Sook Song, Hye Suk Lee
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 799 (2024)
Zastaprazan (JP-1366), a novel potassium-competitive acid blocker, is a new drug for the treatment of erosive esophagitis. JP-1366 is highly metabolized in human, mouse, and dog hepatocytes but moderately metabolized in rat and monkey hepatocytes whe
Externí odkaz:
https://doaj.org/article/d22f1234d718446cb00384ce6e9851c9
Autor:
Byung Jo Choi, Min Hee Park, Kang Ho Park, Wan Hui Han, Hee Ji Yoon, Hye Yoon Jung, Ju Yeon Hong, Md Riad Chowdhury, Kyung Yeol Kim, Jihoon Lee, Im-Sook Song, Minyeong Pang, Min-Koo Choi, Erich Gulbins, Martin Reichel, Johannes Kornhuber, Chang-Won Hong, Changho Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, Jae-sung Bae
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide, and previous work has shown it is upregulated in models of Alzheimer’s disease. Here the authors demonstrate in a mouse mo
Externí odkaz:
https://doaj.org/article/52c99cf51ae64f39b52ec19ee7f53cf4
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3532-3539 (2023)
Stability of compounds in the human plasma is crucial for maintaining sufficient systemic drug exposure and considered an essential factor in the early stages of drug discovery and development. The rapid degradation of compounds in the plasma can res
Externí odkaz:
https://doaj.org/article/bd4d78c3b6b540fa9bbc02740bd52450
Autor:
Bo Min Kim, Hyo Sook Song, Jin-Young Kim, Eun Young Kwon, Seung Yeon Ha, Minsuk Kim, Ji Ha Choi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The ATP-binding cassette subfamily 4 (ABCA4), a transporter, is localized within the photoreceptors of the retina, and its genetic variants cause retinal dystrophy. Despite the clinical importance of the ABCA4 transporter, a few studies have
Externí odkaz:
https://doaj.org/article/ff2d14dfca2f448ca17be7564a682797
Publikováno v:
Pharmaceutical Biology, Vol 60, Iss 1, Pp 2266-2275 (2022)
Context Zeaxanthin is a yellow‑coloured dietary carotenoid widely recognized as an essential component of the macula. It exerts blue light filtering and antioxidant activities, offering eye health and vision benefits.Objective This study explores t
Externí odkaz:
https://doaj.org/article/783f723bfea246688224670c5ab18bdb
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 2320-2329 (2022)
Dimerized translationally controlled tumor protein (dTCTP) initiates a variety of allergic responses in mouse models and that dTCTP-binding peptide 2 (dTBP2) attenuates the allergic inflammation by targeting dTCTP. However, the usefulness of peptide-
Externí odkaz:
https://doaj.org/article/540b00f3da5f468397d18edf560d8a92