Zobrazeno 1 - 10
of 266
pro vyhledávání: '"In Silico Biology"'
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111322- (2024)
Summary: As single-cell omics data sampling and acquisition methods have accumulated at an unprecedented rate, various data analysis pipelines have been developed for the inference of cell types, cell states and their distribution, state transitions,
Externí odkaz:
https://doaj.org/article/ffd54397a9ed491393ae30fd64074d6f
Autor:
Qixiu Du, May Nee Poon, Xiaocheng Zeng, Pengcheng Zhang, Zheng Wei, Haochen Wang, Ye Wang, Lei Wei, Xiaowo Wang
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111207- (2024)
Summary: Generative design of promoters has enhanced the efficiency of de novo creation of functional sequences. Though several deep generative models have been employed in biological sequence generation, including variational autoencoder (VAE) or Wa
Externí odkaz:
https://doaj.org/article/adac8f097edc43f198e1100c142fd735
Autor:
Aditi Ajith Pujar, Arnab Barua, Partha Sarathi Dey, Divyoj Singh, Ushasi Roy, Mohit Kumar Jolly, Haralampos Hatzikirou
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110569- (2024)
Summary: Notch-Delta-Jagged (NDJ) signaling among neighboring cells contributes crucially to spatiotemporal pattern formation and developmental decision-making. Despite numerous detailed mathematical models, their high-dimensionality parametric space
Externí odkaz:
https://doaj.org/article/d2350b3ceb6e483d85e1a358944fcf42
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110807- (2024)
Summary: To understand the decision process of genomic sequence-to-function models, explainable AI algorithms determine the importance of each nucleotide in a given input sequence to the model’s predictions and enable discovery of cis-regulatory mo
Externí odkaz:
https://doaj.org/article/8f3a383a731246f99583eb388e538124
Autor:
Ce Liang, Arsalan Marghoub, Antonio Profico, Costantino Buzi, Marius Didziokas, Lara van de Lande, Roman Hossein Khonsari, David Johnson, Paul O’Higgins, Mehran Moazen
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110617- (2024)
Summary: Our fundamental understanding of the physico-mechanical forces that drive the size and shape changes of the cranium during ontogeny are limited. Biomechanical models based on finite element method present a huge opportunity to address this c
Externí odkaz:
https://doaj.org/article/20b3a91418e547aab2d525de138106f7
Publikováno v:
In iScience 20 December 2024 27(12)
Autor:
Lorenzo Cuollo, Samuele Di Cristofano, Annamaria Sandomenico, Emanuela Iaccarino, Angela Oliver, Alessandra Zingoni, Marco Cippitelli, Cinzia Fionda, Sara Petillo, Andrea Kosta, Valentina Tassinari, Maria Teresa Petrucci, Francesca Fazio, Menotti Ruvo, Angela Santoni, Domenico Raimondo, Alessandra Soriani
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109814- (2024)
Summary: 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) is the endogenous agonist of STING; as such, cGAMP has powerful immunostimulatory activity, due to its capacity to stimulate type I interferon-mediated immunity. Recen
Externí odkaz:
https://doaj.org/article/d8e6f044263540b99c87c79122f65561
Autor:
Mikhail Lebedin, Christoph Ratswohl, Amar Garg, Marta Schips, Clara Vázquez García, Lisa Spatt, Charlotte Thibeault, Benedikt Obermayer, January Weiner, 3rd, Ilais Moreno Velásquez, Cathrin Gerhard, Paula Stubbemann, Leif-Gunnar Hanitsch, Tobias Pischon, Martin Witzenrath, Leif Erik Sander, Florian Kurth, Michael Meyer-Hermann, Kathrin de la Rosa
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109330- (2024)
Summary: Identifying immune modulators that impact neutralizing antibody responses against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is of great relevance. We postulated that high serum concentrations of soluble angiotensin-co
Externí odkaz:
https://doaj.org/article/7c9c5701df2748eb9bb1238451f24137
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108756- (2024)
Summary: Compound-protein interaction (CPI) affinity prediction plays an important role in reducing the cost and time of drug discovery. However, the interpretability of how fragments function in CPI is impacted by the fact that current methods ignor
Externí odkaz:
https://doaj.org/article/ec33f8d55b724ad2a6abfc7f8a40a680
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108398- (2023)
Summary: Spatiotemporal patterns of cellular resting potential regulate several aspects of development. One key aspect of the bioelectric code is that transcriptional and morphogenetic states are determined not by local, single-cell, voltage levels b
Externí odkaz:
https://doaj.org/article/0b7c84910d1d4a0eae531537944a9a95