Zobrazeno 1 - 10
of 673
pro vyhledávání: '"In Koo, Hwang"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB) plays an essential role in glycolysis and in the antioxidant pathway associated with glutathione. Therefore, we investigated the effects of PFKFB3 on oxidative and ische
Externí odkaz:
https://doaj.org/article/6baf2fded24841ba9928a1baffd8af0e
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23488- (2024)
Background: Bain ischemia is a disease that occurs for various reasons, induces reactive oxygen species (ROS), and causes fatal damage to the nervous system. Protective effect of HPCA on ischemic injury has not been extensively studied despite its si
Externí odkaz:
https://doaj.org/article/874e41eb29b449a4a95e2e8c5627840d
Autor:
Hyun Jung Kwon, Kyu Ri Hahn, Min Soo Kang, Jung Hoon Choi, Seung Myung Moon, Yeo Sung Yoon, In Koo Hwang, Dae Won Kim
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Malate dehydrogenase (MDH) plays an important role in the conversion of malate to oxaloacetate during the tricarboxylic acid cycle. In this study, we examined the role of cytoplasmic MDH (MDH1) in hydrogen peroxide (H2O2)-induced oxidative s
Externí odkaz:
https://doaj.org/article/09c701a38ca04539957d572bd1aa2a6b
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Carboxyl terminus of Hsc70-interacting protein (CHIP) is highly conserved and is linked to the connection between molecular chaperones and proteasomes to degrade chaperone-bound proteins. In this study, we synthesized the transactivator of t
Externí odkaz:
https://doaj.org/article/686815f674614d6faea2720c0be05a05
Autor:
Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Min Soo Kang, Hyun Jung Kwon, Jung Hoon Choi, Yeo Sung Yoon, Dae Won Kim, Dae Young Yoo, Moo-Ho Won, In Koo Hwang
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 24, Iss 11, Pp 1482-1487 (2021)
Objective(s): Vacuolar H+-ATPase is a highly conserved enzyme that plays an important role in maintaining an acidic environment for lysosomal function and accumulating neurotransmitters in synaptic vesicles. In the present study, we investigated the
Externí odkaz:
https://doaj.org/article/3dd1e5b1395e430e9c0b9c8a7c119625
Autor:
Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Sung Min Nam, Sun Shin Yi, Hyun Jung Kwon, Min Soo Kang, Jung Hoon Choi, Dae Won Kim, Yeo Sung Yoon, In Koo Hwang
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 24, Iss 7, Pp 908-913 (2021)
Objective(s): Prostaglandin E2 E-prostanoid 2 receptor (PGE2 EP2), downstream of cyclooxygenase-2 (COX-2), plays an important role in inflammatory responses, but there are some reports about synaptic functions of COX-2 and PGE2 EP2 in the hippocampus
Externí odkaz:
https://doaj.org/article/d6139aef73014569ad7ce5e582b04acf
Autor:
Dae Young Yoo, Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Hyun Jung Kwon, Sung Min Nam, Jin Young Chung, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 6, Pp 1005-1110 (2021)
Entacapone, a catechol-O-methyltransferase inhibitor, can strengthen the therapeutic effects of levodopa on the treatment of Parkinson’s disease. However, few studies are reported on whether entacapone can affect hippocampal neurogenesis in mice. T
Externí odkaz:
https://doaj.org/article/ed2b4328f3784350ada2de2afc4b6db1
Autor:
Min Soo Kang, Woosuk Kim, Tae Hyeong Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim, In Koo Hwang, Jung Hoon Choi
Publikováno v:
Laboratory Animal Research, Vol 36, Iss 1, Pp 1-9 (2020)
Abstract Fat-mass and obesity-associated protein (Fto) is highly expressed in the brain including, the hippocampus, and its expression is significantly decreased in the brain of Alzheimer’s disease patients. In the present study, we measured Fto im
Externí odkaz:
https://doaj.org/article/b691e82007514b24a720b36c4a4e7417
Autor:
Sumin Yun, Woosuk Kim, Min Soo Kang, Tae Hyeong Kim, Yoonhwan Kim, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang, Jin-Young Chung
Publikováno v:
BMC Neuroscience, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Pyridoxine (PDX; vitamin B6), is an essential vitamin. PDX deficiency induces various symptoms, and when PDX is misused it acts as a neurotoxicant, inducing severe sensory neuropathy. Results To assess the possibility of creating
Externí odkaz:
https://doaj.org/article/9cb505ef7e32439c97ab952b1c78d436
Autor:
Hyun-Kee Cho, Woosuk Kim, Kwon-Young Lee, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang, Jin-Young Chung
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 1, Pp 162-168 (2020)
Beta-nerve growth factor (β-NGF) is known to be a major leading cause of neuronal plasticity. To identify the possible action mechanisms of β-NGF gene therapy for sciatic nerve recovery, experimental dogs were randomly divided into control, pyridox
Externí odkaz:
https://doaj.org/article/30eb68f366ec4bec816ee453325e6bbc