Zobrazeno 1 - 10
of 41 766
pro vyhledávání: '"In‐Hee Lee"'
Autor:
Ji-Won Lee, Kaito Mizuno, Haruhisa Watanabe, In-Hee Lee, Takuya Tsumita, Kyoko Hida, Yasutaka Yawaka, Yoshimasa Kitagawa, Akira Hasebe, Tadahiro Iimura, Sek Won Kong
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Multinucleated microglia have been observed in contexts associated with infection, inflammation, and aging. Though commonly linked to pathological conditions, the larger cell size of multinucleated microglia might enhance their phagocytic fu
Externí odkaz:
https://doaj.org/article/42390726e32e40f7b382cf7f7dcc8d93
Autor:
Ji-Won Lee, In-Hee Lee, Haruhisa Watanabe, Yunqing Liu, Kazuaki Sawada, Masashi Maekawa, Shunsuke Uehara, Yasuhiro Kobayashi, Yuuki Imai, Sek Won Kong, Tadahiro Iimura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the resorbing bone surface. However, the regulatory mechanisms an
Externí odkaz:
https://doaj.org/article/dccf3fbc05964da5941a3b4688ff3648
Autor:
In-Hee Lee, Matthew Ryan Smith, Azam Yazdani, Sumiti Sandhu, Douglas I. Walker, Kenneth D. Mandl, Dean P. Jones, Sek Won Kong
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-14 (2022)
Abstract Background The human exposome is composed of diverse metabolites and small chemical compounds originated from endogenous and exogenous sources, respectively. Genetic and environmental factors influence metabolite levels, while the extent of
Externí odkaz:
https://doaj.org/article/e53b8a652d42422ca398f6c06db3d480
Autor:
In-Hee Lee, Douglas I. Walker, Yufei Lin, Matthew Ryan Smith, Kenneth D. Mandl, Dean P. Jones, Sek Won Kong
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104746- (2023)
Summary: Background: Unravelling the relationships between candidate genes and autism spectrum disorder (ASD) phenotypes remains an outstanding challenge. Endophenotypes, defined as inheritable, measurable quantitative traits, might provide intermedi
Externí odkaz:
https://doaj.org/article/c16ac138231a4ce8923a5cea90341a7e
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Autism spectrum disorder (ASD) represents a heterogeneous group of neurodevelopmental disorders and is largely attributable to genetic risk factors. Phenotypic and genetic heterogeneity of ASD have been well-recognized; however, genetic subs
Externí odkaz:
https://doaj.org/article/795fe03a397c48aab92efb8840d70e7c
Publikováno v:
eLife, Vol 11 (2022)
Pediatric acute respiratory distress syndrome (PARDS), though both common and deadly in critically ill children, lacks targeted therapies. The development of effective pharmacotherapies has been limited, in part, by lack of clarity about the pathobio
Externí odkaz:
https://doaj.org/article/c95a16b2ae7446278ab6fc0b84130fad
Autor:
In-Hee Lee, Yufei Lin, William Jefferson Alvarez, Carles Hernandez-Ferrer, Kenneth D. Mandl, Sek Won Kong
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Whole exome sequencing (WES) is widely adopted in clinical and research settings; however, one of the practical concerns is the potential false negatives due to incomplete breadth and depth of coverage for several exons in clinica
Externí odkaz:
https://doaj.org/article/1eed6270bc814a5da9868696bb4f7177
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-10 (2021)
Abstract Tissue-resident macrophages are highly specialized to their tissue-specific microenvironments, activated by various inflammatory signals and modulated by genetic and environmental factors. Osteoclasts and microglia are distinct tissue-reside
Externí odkaz:
https://doaj.org/article/9ebdacaa3b454f7c9db35929423236f8
Publikováno v:
Frontiers in Energy Research, Vol 10 (2022)
The high levels of energy consumption commonly seen today have severe consequences. For example, energy consumption in buildings traditionally takes the form of electricity generated from fossil fuels, which causes serious air pollution. Hence, the e
Externí odkaz:
https://doaj.org/article/8e79e2f92f414910bd79360a0a8ca3cd
Autor:
Harim Koo, Seung Won Choi, Hee Jin Cho, In‐Hee Lee, Doo‐Sik Kong, Ho Jun Seol, Jung‐Il Lee, Jung‐Won Choi, Jason K. Sa, Do‐Hyun Nam
Publikováno v:
Cancer Medicine, Vol 9, Iss 19, Pp 7352-7359 (2020)
Abstract Glioblastoma (GBM) is the most malignant primary brain tumor in adults with substantial genomic alterations. The median survival is approximately 14.6 months, despite aggressive therapeutic intervention, which comprised of surgical resection
Externí odkaz:
https://doaj.org/article/b389460c6d714d49a5b929ecdab0bbee