Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Inês S. Albuquerque"'
Autor:
Diana Moita, Teresa G. Maia, Miguel Duarte, Carolina M. Andrade, Inês S. Albuquerque, Ankit Dwivedi, Joana C. Silva, Lilia González-Céron, Chris J. Janse, António M. Mendes, Miguel Prudêncio
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Two malaria parasite species, Plasmodium falciparum (Pf) and P. vivax (Pv) are responsible for most of the disease burden caused by malaria. Vaccine development against this disease has focused mainly on Pf. Whole-sporozoite (WSp) vaccinatio
Externí odkaz:
https://doaj.org/article/e826d5ba7493466aa874bf76000cc79f
Autor:
Barbara Bernardim, Pedro M.S.D. Cal, Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Inês S. Albuquerque, Elizabeth Perkins, Francisco Corzana, Antonio C.B. Burtoloso, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Current cysteine bioconjugation strategies for protein-drug conjugates synthesis often yield heterogeneous and poorly stable products. Here, the authors use carbonylacrylic derivatives to selectively modify cysteine residues and synthesize biological
Externí odkaz:
https://doaj.org/article/c0d7ebdccc9c4ce596735356cd570e4c
Publikováno v:
Biochemistry. 58:2861-2866
Funded by the Royal Society (URF\R\180019 to G.J.L.B.) and FCT Portugal (iFCT IF/00624/2015 to G.J.L.B., Postdoctoral Fellowships SFRH/BPD/118731/2016 to M.C.M. and SFRH/BPD/81627/2011 to S.H.V., and Doctoral Studentship SFRH/BD/111556/2015 to I.S.A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd497bfdf07e121ffb03ef5cc6b7612e
https://doi.org/10.1021/acs.biochem.9b00224
https://doi.org/10.1021/acs.biochem.9b00224
Autor:
Inês S. Albuquerque, Noemi Frusciante
Publikováno v:
Physics of the Dark Universe. 35:100980
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8ca5816047368ba0b776f116633cdb3
https://doi.org/10.1016/j.dark.2022.100980
https://doi.org/10.1016/j.dark.2022.100980
Autor:
Pedro M. F. Sousa, Marcos F. Q. Sousa, Tiago Rodrigues, João Seixas, Shelby K. Doyle, Di Wu, Carol V. Robinson, Tiago M. Bandeiras, Ana Guerreiro, Angela N. Koehler, Rui Traquete, Bárbara B. Sousa, Pedro M. Matias, Inês S. Albuquerque, Gonçalo J. L. Bernardes, Francisco Corzana, Marta C. Marques, Ana Lemos
BMX is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with single-digit nanomolar potency with unexploited topological pharmacophore patterns. Importantly, we reveal the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f22a97a760f84e84132679e93b380d
https://doi.org/10.26434/chemrxiv.11558310
https://doi.org/10.26434/chemrxiv.11558310
Autor:
Ismael Compañón, Filipa Marcelo, Vincenzo Mangini, Ana García-García, Francisco Corzana, Alicia Asín, Javier Macías-León, Inês S. Albuquerque, Iris A. Bermejo, Hiren J. Joshi, Gonçalo J. L. Bernardes, Ramon Hurtado-Guerrero, Juan Luis Asensio, Ola Blixt, Ester Jiménez-Moreno, Helena Coelho, Roberto Fiammengo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Macías-León, J, Bermejo, I A, Asín, A, García-García, A, Compañón, I, Jiménez-Moreno, E, Coelho, H, Mangini, V, Albuquerque, I S, Marcelo, F, Asensio, J L, Bernardes, G J L, Joshi, H J, Fiammengo, R, Blixt, O, Hurtado-Guerrero, R & Corzana, F 2020, ' Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody ', Chemical communications (Cambridge, England), vol. 56, no. 96, pp. 15137-15140 . https://doi.org/10.1039/d0cc06349e
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Macías-León, J, Bermejo, I A, Asín, A, García-García, A, Compañón, I, Jiménez-Moreno, E, Coelho, H, Mangini, V, Albuquerque, I S, Marcelo, F, Asensio, J L, Bernardes, G J L, Joshi, H J, Fiammengo, R, Blixt, O, Hurtado-Guerrero, R & Corzana, F 2020, ' Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody ', Chemical communications (Cambridge, England), vol. 56, no. 96, pp. 15137-15140 . https://doi.org/10.1039/d0cc06349e
Zaguán. Repositorio Digital de la Universidad de Zaragoza
The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These finding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c407c3150382510057b29f06a112b36
http://hdl.handle.net/10261/231221
http://hdl.handle.net/10261/231221
Autor:
Ana Lemos, Marta C. Marques, Shelby K. Doyle, Angela N. Koehler, Di Wu, Rui Traquete, Bárbara B. Sousa, Inês S. Albuquerque, Gonçalo J. L. Bernardes, João D Seixas, Ana Guerreiro, Francisco Corzana, Carol V. Robinson, Tiago M. Bandeiras, Tiago Rodrigues, Marcos F. Q. Sousa, Pedro M. F. Sousa, Pedro M. Matias
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
RSC Chemical Biology
'RSC Chemical Biology ', vol: 1, pages: 251-262 (2020)
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
RSC Chemical Biology
'RSC Chemical Biology ', vol: 1, pages: 251-262 (2020)
This journal is © The Royal Society of Chemistry 2020.
The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with singl
The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0112212e065374ecc5739886d4f4e98a
Autor:
Daniela Miranda, Francisca Lopes, Inês S. Albuquerque, Rui Moreira, Margarida Sanches-Vaz, Marta Machado, Moni Sharma, Maria de Jesus Perry, Joana Magalhães, Miguel Prudêncio, Philip J. Rosenthal, Rita Capela, Raquel F. M. Frade, Jiri Gut
Publikováno v:
European Journal of Medicinal Chemistry
Hybrid compounds may play a critical role in the context of the malaria eradication agenda, which will benefit from therapeutic tools active against the symptomatic erythrocytic stage of Plasmodium infection, and also capable of eliminating liver sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18917fd79c320b8c1859cb9d56371cde
https://doi.org/10.1016/j.ejmech.2018.02.048
https://doi.org/10.1016/j.ejmech.2018.02.048
The recent discovery of the osmosensitive calcium (Ca2+) channel OSCA has revealed the potential mechanism by which plant cells sense diverse stimuli. Osmosensory transporters and mechanosensitive channels can detect and respond to osmotic shifts tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38741d3dcfcd24ef6d68a8a860c7dc6e
Publikováno v:
Physical Review D. 98
We propose a viable dark energy scenario in the presence of cubic Horndeski interactions and a standard scalar-field kinetic term with two exponential potentials. We show the existence of new scaling solutions along which the cubic coupling $G_3$ pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92988cf5af9b2c9619bea71d58d96e0d
https://doi.org/10.1103/physrevd.98.064038
https://doi.org/10.1103/physrevd.98.064038