Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide–Pyrazole Hybrids

Autor: Patrícia S. M. Amado, Inês C. C. Costa, José A. Paixão, Ricardo F. Mendes, Sofia Cortes, Maria L. S. Cristiano

Publikováno v: Molecules, Vol 27, Iss 17, p 5401 (2022)

Leishmaniases are among the most impacting neglected tropical diseases. In attempts to repurpose antimalarial drugs or candidates, it was found that selected 1,2,4-trioxanes, 1,2,4,5-tetraoxanes, and pyrazole-containing chemotypes demonstrated activi

Externí odkaz: https://doaj.org/article/cf90b761f92443a19cc59940ce9b3181

Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis-A Short Bridge between Two Distant Illnesses

Autor: Maria Lurdes Santos Cristiano, Paul M. O'Neill, Alina Secrieru, Inês C C Costa

Publikováno v: Molecules
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
MOLECULES
Molecules, Vol 25, Iss 1574, p 1574 (2020)

Toxoplasmosis is an infectious disease with paramount impact worldwide, affecting many vulnerable populations and representing a significant matter of concern. Current therapies used against toxoplasmosis are based essentially on old chemotypes, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab770338d251a6972d79af60c95bd688
https://pubmed.ncbi.nlm.nih.gov/32235463