Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Inés Morano"'
Autor:
Ann Logan, Antonio Belli, Valentina Di Pietro, Barbara Tavazzi, Giacomo Lazzarino, Renata Mangione, Giuseppe Lazzarino, Inés Morano, Omar Qureshi, Lars Bruce, Nicholas M. Barnes, Zsuzsanna Nagy
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Acute and chronic neurodegenerative diseases represent an immense socioeconomic burden that drives the need for new disease modifying drugs. Common pathogenic mechanisms in these diseases are evident, suggesting that a platform neuroprote
Externí odkaz:
https://doaj.org/article/5f494b80def644158b890d705076d295
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would assist to further elucidate receptor sub-type function and promote developme
Externí odkaz:
https://doaj.org/article/c90815da60ca4e659303d9709faffaad
Autor:
Kramer James Bernard, M.C. Holt, Stephen Douglas Barrett, Chi S. Ho, James Paul O'malley, Thomas A. Owen, Adam Uzieblo, Fred L. Ciske, A.J. Stein, Joseph Michael Colombo, María Inés Morano, Bradlee David Germain, Andrei M. Kornilov
Publikováno v:
Journal of Medicinal Chemistry. 62:4731-4741
A series of small-molecule full agonists of the prostaglandin E2 type 4 (EP4) receptor have been generated and evaluated for binding affinity and cellular potency. KMN-80 and its gem-difluoro analog KMN-159 possess high selectivity relative to other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88923961862f6d74c0e74bf2838231ec
https://doi.org/10.1021/acs.jmedchem.9b00336
https://doi.org/10.1021/acs.jmedchem.9b00336
Autor:
Thomas A, Owen, Chandni, Patel, Shanqiao, Wei, Chi S, Ho, Kaylah, Birmingham, Samuel, Sanchez, Natalie, Chung, Alexa, Cahill, James P, O'Malley, Stephen D, Barrett, María Inés, Morano
Publikováno v:
Gene
KMN-159 is the lead compound from a series of novel difluorolactam prostanoid EP(4) receptor agonists aimed at inducing local bone formation while avoiding the inherent side effects of systemic EP(4) activation. KMN-159 is a potent, selective small m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d32ae0be4b6ca1f666f2bc0850adc29
https://pubmed.ncbi.nlm.nih.gov/32334025
https://pubmed.ncbi.nlm.nih.gov/32334025
Autor:
Stephen Douglas Barrett, Kaylah Birmingham, Alexa Cahill, Chandni Patel, James Paul O'malley, Shanqiao Wei, Samuel Sanchez, Thomas A. Owen, María Inés Morano, Natalie Chung, Chi S. Ho
Publikováno v:
Gene. 748:144668
KMN-159 is the lead compound from a series of novel difluorolactam prostanoid EP4 receptor agonists aimed at inducing local bone formation while avoiding the inherent side effects of systemic EP4 activation. KMN-159 is a potent, selective small molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d85aa8c8d891584720ff41903fba4f5
https://doi.org/10.1016/j.gene.2020.144668
https://doi.org/10.1016/j.gene.2020.144668
Autor:
Neale Harrison, Lauren Richardson, Chiara Pallini, Ines Morano, Elizabeth Jinks, Jamie Cowley, Hujo Chan, Harriet J. Hill, Aekkachai Tuekprakhon, Zhi Li, Cristina Matas de las Heras, Ana Teodosio, Andrea S. Lavado, Robert Moring, Ayesha Ashraf, Timothy R. Dafforn, Dimitris K. Grammatopoulos, John Gordon, Catherine A. Brady, Lawrence S. Young, Nicholas M. Barnes, Zania Stamataki, Omar S. Qureshi
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
IntroductionThe engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells, and, therefore, blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine e
Externí odkaz:
https://doaj.org/article/8359357ba2624784b5140879793cd87d
Autor:
William B. Pratt, Huda Akil, Claudio A. Caamaño, M. Inés Morano, Friedrich C. Dalman, Stanley J. Watson
Publikováno v:
Annals of the New York Academy of Sciences. 746:68-77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeae21324b7adb2d9d88f672e5055ae9
https://doi.org/10.1111/j.1749-6632.1994.tb39213.x
https://doi.org/10.1111/j.1749-6632.1994.tb39213.x
Autor:
Claudio A. Caamaño, Stanley J. Watson, M. Inés Morano, Lars Christian B. Rønn, Manuel O. López-Figueroa, Huda Akil
Publikováno v:
Biochemical and Biophysical Research Communications. 272:129-133
Nitric oxide (NO) has been implicated in the modulation of mitochondrial respiration, membrane potential, and subsequently in apoptosis. Although the presence of a mitochondrial NO synthase (mtNOS) has been described, there is no direct evidence in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a862311dddb5725c73f5b1dac67b795
https://doi.org/10.1006/bbrc.2000.2748
https://doi.org/10.1006/bbrc.2000.2748
Autor:
Huda Akil, Delia M. Vazquez, Seung Kwak, Juan F. Lopez, Stanley J. Watson, Marı́a Inés Morano
Publikováno v:
Endocrinology. 139:3165-3177
Two different types of corticoid receptor molecules bind circulating corticosterone in brain: mineralocorticoid receptors (MR) and glucocorticoid receptors. MR exhibit the highest affinity for the endogenous glucocorticoid in the rat, corticosterone.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216a01f06bf98aae03647e2af908885c
https://doi.org/10.1210/endo.139.7.6095
https://doi.org/10.1210/endo.139.7.6095
Publikováno v:
Stress. 2:101-112
The current study was conducted to determine the potential relationship between stress-induced corticosterone secretion and corticosteroid receptor mRNA levels after 5 days of intermittent stress. In particular, we were interested in the rate at whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f98e17511cf1095425ad84da57eb97a
https://doi.org/10.3109/10253899709014741
https://doi.org/10.3109/10253899709014741