Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Inés G. Muñoz"'
Autor:
Hipólito Nicolás Cuesta-Hernández, Julia Contreras, Pablo Soriano-Maldonado, Jana Sánchez-Wandelmer, Wayland Yeung, Ana Martín-Hurtado, Inés G. Muñoz, Natarajan Kannan, Marta Llimargas, Javier Muñoz, Iván Plaza-Menacho
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear. Here we show that c-termi
Externí odkaz:
https://doaj.org/article/c3b166424ee543e296abfd732eab6d76
Autor:
Pilar Mur, Julen Viana-Errasti, Sandra García-Mulero, Lorena Magraner-Pardo, Inés G. Muñoz, Tirso Pons, Gabriel Capellá, Marta Pineda, Lidia Feliubadaló, Laura Valle
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Germline variants affecting the proofreading activity of polymerases epsilon and delta cause a hereditary cancer and adenomatous polyposis syndrome characterized by tumors with a high mutational burden and a specific mutational sp
Externí odkaz:
https://doaj.org/article/0d8eedbedf5a4275aa0193c67a801de8
Autor:
Rodrigo Lázaro‐Gorines, Patricia Pérez, Ignacio Heras‐Murillo, Irene Adán‐Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L. Harwood, Alejandro Segura‐Tudela, Laura Rubio‐Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A. Adipietro, Dinendra L. Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D. MacKerell Jr, Laura Sanz, David J. Weber, Francisco J. Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy‐Ruiz, Inés G. Muñoz, Rafael Delgado, David Sancho, Juan García‐Arriaza, Luis Álvarez‐Vallina
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Administration of neutralizing antibodies (nAbs) has proved to be effective by providing immediate protection against SARS‐CoV‐2. However, dual strategies combining virus neutralization and immune response stimulation to enhance specific
Externí odkaz:
https://doaj.org/article/83ee823ecfc342e88a1c1efafa321622
Autor:
Siseth Martínez-Caballero, Céline Freton, Rafael Molina, Sergio G. Bartual, Virginie Gueguen-Chaignon, Chryslène Mercy, Federico Gago, Kiran V. Mahasenan, Inés G. Muñoz, Mijoon Lee, Dusan Hesek, Shahriar Mobashery, Juan A. Hermoso, Christophe Grangeasse
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112756- (2023)
Summary: Bacterial cell-wall hydrolases must be tightly regulated during bacterial cell division to prevent aberrant cell lysis and to allow final separation of viable daughter cells. In a multidisciplinary work, we disclose the molecular dialogue be
Externí odkaz:
https://doaj.org/article/d81c8fc5e2aa4f5d9ff7f86ec5f0dc25
Autor:
Rati Lama, Chao Xu, Samuel L. Galster, Javier Querol-García, Scott Portwood, Cory K. Mavis, Federico M. Ruiz, Diana Martin, Jin Wu, Marianna C. Giorgi, Jill Bargonetti, Eunice S. Wang, Francisco J. Hernandez-Ilizaliturri, Gerald B. Koudelka, Sherry R. Chemler, Inés G. Muñoz, Xinjiang Wang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
MDM2 and MDM4 proteins are key negative regulators of tumor suppressor p53. MDM2 and MDM4 interact via their RING domains and form a heterodimer polyubiquitin E3 ligase essential for p53 degradation. MDM4 also forms heterodimer E3 ligases with MDM2 i
Externí odkaz:
https://doaj.org/article/ac45ea6ffa8a496fa654d17db6618c95
Autor:
Siseth Martínez-Caballero, Kiran V. Mahasenan, Choon Kim, Rafael Molina, Rhona Feltzer, Mijoon Lee, Renee Bouley, Dusan Hesek, Jed F. Fisher, Inés G. Muñoz, Mayland Chang, Shahriar Mobashery, Juan A. Hermoso
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5392-5405 (2021)
The penicillin-binding proteins are the enzyme catalysts of the critical transpeptidation crosslinking polymerization reaction of bacterial peptidoglycan synthesis and the molecular targets of the penicillin antibiotics. Here, we report a combined cr
Externí odkaz:
https://doaj.org/article/0af59740be1241078a1417fa0b394874
Autor:
Gulnahar B. Mortuza, Dario Hermida, Anna-Kathrine Pedersen, Sandra Segura-Bayona, Blanca López-Méndez, Pilar Redondo, Patrick Rüther, Irina Pozdnyakova, Ana M. Garrote, Inés G. Muñoz, Marina Villamor-Payà, Cristina Jauset, Jesper V. Olsen, Travis H. Stracker, Guillermo Montoya
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The Tousled-like kinase (TLKs) family belongs to a distinct branch of Ser/Thr kinases that exhibit the highest levels of activity during DNA replication. Here the authors present the crystal structure of the kinase domain from human TLK2 and propose
Externí odkaz:
https://doaj.org/article/5782a4cbd30a44858e898e8e1633bd30
Autor:
Nicolás Cuesta, Julia Contreras, Jana Sánchez-Waldermer, Pablo Soriano-Maldonado, Ana Martín-Hurtado, Inés G. Muñoz, Marta Llimargas, Javier Muñoz, Iván Plaza Menacho
SummaryAuto-phosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlaying this fundamental process remain unclear. Here we show that c-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfcf5975305e9e8831390523a1ec27a8
https://doi.org/10.1101/2022.10.16.512342
https://doi.org/10.1101/2022.10.16.512342
Autor:
Kiran V. Mahasenan, Rhona Feltzer, Dusan Hesek, Mijoon Lee, Renee Bouley, Siseth Martínez-Caballero, Choon Kim, Jed F. Fisher, Shahriar Mobashery, Rafael Molina, Juan A. Hermoso, Inés G. Muñoz, Mayland Chang
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5392-5405 (2021)
instname
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5392-5405 (2021)
Graphical abstract
Highlights • X-ray crystallography, SAXS and MD simulations elucidates the 3D structure for saPBP1. • 3D structure of saPBP1 reveals dynamical mobility for the pedestal and PASTA domains. • Structures with β-lactams and
Highlights • X-ray crystallography, SAXS and MD simulations elucidates the 3D structure for saPBP1. • 3D structure of saPBP1 reveals dynamical mobility for the pedestal and PASTA domains. • Structures with β-lactams and
Autor:
Francisco J. Blanco, Miguel Ángel Morcillo, Ainhoa Erce-Llamazares, Nekane Merino, Eva M. Garrido-Martin, Luis Álvarez-Vallina, Ignacio Melero, Laura Sanz, Antonio Tapia-Galisteo, Marta Oteo, Ángel Ramírez-Fernández, Irene Ferrer, Seandean Lykke Harwood, Eduardo Romero, Belén Blanco, Manuela Zonca, Carmen Domínguez-Alonso, Oana Hangiu, Inés G. Muñoz, Maria C. Ochoa, Marta Compte, Luis Paz-Ares, Ana Belén Enguita, Daniel Nehme-Álvarez, José Luis Rodríguez-Peralto
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Compte, M, Harwood, S L, Erce-Llamazares, A, Tapia-Galisteo, A, Romero, E, Ferrer, I, Garrido-Martin, E M, Enguita, A B, Ochoa, M C, Blanco, B, Oteo, M, Merino, N, Nehme-Alvarez, D, Hangiu, O, Domínguez-Alonso, C, Zonca, M, Ramírez-Fernandez, A, Blanco, F J, Morcillo, M A, Muñoz, I G, Melero, I, Rodriguez-Peralto, J L, Paz-Ares, L, Sanz, L & Alvarez-Vallina, L 2021, ' An Fc-free EGFR-specific 4-1BB-agonistic trimerbody displays broad antitumor activity in humanized murine cancer models without toxicity ', Clinical Cancer Research, vol. 27, no. 11, pp. 3167-3177 . https://doi.org/10.1158/1078-0432.CCR-20-4625
instname
Compte, M, Harwood, S L, Erce-Llamazares, A, Tapia-Galisteo, A, Romero, E, Ferrer, I, Garrido-Martin, E M, Enguita, A B, Ochoa, M C, Blanco, B, Oteo, M, Merino, N, Nehme-Alvarez, D, Hangiu, O, Domínguez-Alonso, C, Zonca, M, Ramírez-Fernandez, A, Blanco, F J, Morcillo, M A, Muñoz, I G, Melero, I, Rodriguez-Peralto, J L, Paz-Ares, L, Sanz, L & Alvarez-Vallina, L 2021, ' An Fc-free EGFR-specific 4-1BB-agonistic trimerbody displays broad antitumor activity in humanized murine cancer models without toxicity ', Clinical Cancer Research, vol. 27, no. 11, pp. 3167-3177 . https://doi.org/10.1158/1078-0432.CCR-20-4625
32 p.-4 fig.
Purpose: The induction of 4-1BB signaling by agonistic antibodies can drive the activation and proliferation of effector T cells and thereby enhance a T-cell–mediated antitumor response. Systemic administration of anti-4-1BB–ago
Purpose: The induction of 4-1BB signaling by agonistic antibodies can drive the activation and proliferation of effector T cells and thereby enhance a T-cell–mediated antitumor response. Systemic administration of anti-4-1BB–ago