Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1

Autor: Pilar Mur, Julen Viana-Errasti, Sandra García-Mulero, Lorena Magraner-Pardo, Inés G. Muñoz, Tirso Pons, Gabriel Capellá, Marta Pineda, Lidia Feliubadaló, Laura Valle

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)

Abstract Background Germline variants affecting the proofreading activity of polymerases epsilon and delta cause a hereditary cancer and adenomatous polyposis syndrome characterized by tumors with a high mutational burden and a specific mutational sp

Externí odkaz: https://doaj.org/article/0d8eedbedf5a4275aa0193c67a801de8

Molecular basis of the final step of cell division in Streptococcus pneumoniae

Autor: Siseth Martínez-Caballero, Céline Freton, Rafael Molina, Sergio G. Bartual, Virginie Gueguen-Chaignon, Chryslène Mercy, Federico Gago, Kiran V. Mahasenan, Inés G. Muñoz, Mijoon Lee, Dusan Hesek, Shahriar Mobashery, Juan A. Hermoso, Christophe Grangeasse

Publikováno v: Cell Reports, Vol 42, Iss 7, Pp 112756- (2023)

Summary: Bacterial cell-wall hydrolases must be tightly regulated during bacterial cell division to prevent aberrant cell lysis and to allow final separation of viable daughter cells. In a multidisciplinary work, we disclose the molecular dialogue be

Externí odkaz: https://doaj.org/article/d81c8fc5e2aa4f5d9ff7f86ec5f0dc25

Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus, an essential component of the divisome machinery

Autor: Siseth Martínez-Caballero, Kiran V. Mahasenan, Choon Kim, Rafael Molina, Rhona Feltzer, Mijoon Lee, Renee Bouley, Dusan Hesek, Jed F. Fisher, Inés G. Muñoz, Mayland Chang, Shahriar Mobashery, Juan A. Hermoso

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5392-5405 (2021)

The penicillin-binding proteins are the enzyme catalysts of the critical transpeptidation crosslinking polymerization reaction of bacterial peptidoglycan synthesis and the molecular targets of the penicillin antibiotics. Here, we report a combined cr

Externí odkaz: https://doaj.org/article/0af59740be1241078a1417fa0b394874

An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

Autor: Nicolás Cuesta, Julia Contreras, Jana Sánchez-Waldermer, Pablo Soriano-Maldonado, Ana Martín-Hurtado, Inés G. Muñoz, Marta Llimargas, Javier Muñoz, Iván Plaza Menacho

SummaryAuto-phosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlaying this fundamental process remain unclear. Here we show that c-termi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfcf5975305e9e8831390523a1ec27a8
https://doi.org/10.1101/2022.10.16.512342

An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity

Autor: Francisco J. Blanco, Miguel Ángel Morcillo, Ainhoa Erce-Llamazares, Nekane Merino, Eva M. Garrido-Martin, Luis Álvarez-Vallina, Ignacio Melero, Laura Sanz, Antonio Tapia-Galisteo, Marta Oteo, Ángel Ramírez-Fernández, Irene Ferrer, Seandean Lykke Harwood, Eduardo Romero, Belén Blanco, Manuela Zonca, Carmen Domínguez-Alonso, Oana Hangiu, Inés G. Muñoz, Maria C. Ochoa, Marta Compte, Luis Paz-Ares, Ana Belén Enguita, Daniel Nehme-Álvarez, José Luis Rodríguez-Peralto

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Compte, M, Harwood, S L, Erce-Llamazares, A, Tapia-Galisteo, A, Romero, E, Ferrer, I, Garrido-Martin, E M, Enguita, A B, Ochoa, M C, Blanco, B, Oteo, M, Merino, N, Nehme-Alvarez, D, Hangiu, O, Domínguez-Alonso, C, Zonca, M, Ramírez-Fernandez, A, Blanco, F J, Morcillo, M A, Muñoz, I G, Melero, I, Rodriguez-Peralto, J L, Paz-Ares, L, Sanz, L & Alvarez-Vallina, L 2021, ' An Fc-free EGFR-specific 4-1BB-agonistic trimerbody displays broad antitumor activity in humanized murine cancer models without toxicity ', Clinical Cancer Research, vol. 27, no. 11, pp. 3167-3177 . https://doi.org/10.1158/1078-0432.CCR-20-4625

32 p.-4 fig.
Purpose: The induction of 4-1BB signaling by agonistic antibodies can drive the activation and proliferation of effector T cells and thereby enhance a T-cell–mediated antitumor response. Systemic administration of anti-4-1BB–ago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5dae87d09a6452afe53c02f9006245
https://pubmed.ncbi.nlm.nih.gov/33785484