Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Inès J. Goossens-Beumer"'
Autor:
Peter J.K. Kuppen, Cornelis J.H. van de Velde, Klaus-Peter Janssen, Ulrich Nitsche, Hans Morreau, Stefan Böhringer, Jelle J. Goeman, Henk P.J. Buermans, Remco S. Derr, Inès J. Goossens-Beumer
Supplementary File S7. Predicted target genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf2c2314db27ba5fa8112a91c961da7
https://doi.org/10.1158/1055-9965.22437991
https://doi.org/10.1158/1055-9965.22437991
Autor:
Anne Benard, Inès J Goossens-Beumer, Anneke Q van Hoesel, Hamed Horati, Hein Putter, Eliane C M Zeestraten, Cornelis J H van de Velde, Peter J K Kuppen
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108265 (2014)
Numerous changes in epigenetic mechanisms have been described in various types of tumors. In search for new biomarkers, we investigated the expression of Polycomb-group (PcG) proteins EZH2, BMI1 and SUZ12 and associated histone modification H3K27me3
Externí odkaz:
https://doaj.org/article/d537d1242e5e4e41b2f9a37fdea5390a
Autor:
Hans Morreau, Eliane C. M. Zeestraten, Cornelis J.H. van de Velde, Anne Benard, Gerrit-Jan Liefers, Anneke Q. van Hoesel, Stefan Böhringer, Inès J. Goossens-Beumer, Hein Putter, Peter J. K. Kuppen
Publikováno v:
Translational Research, The Journal of Laboratory and Clinical Medicine, 165(5), 578-588
Aging is one of the prime risk factors for the development of cancer. Expression patterns of epigenetic regulators, including histone modification levels, are altered during aging of normal cells, a phenomenon referred to as epigenetic drift. Further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9225f6e4fcc1290a6e8abfad5736dfd
https://hdl.handle.net/1887/107005
https://hdl.handle.net/1887/107005
Autor:
Klaus-Peter Janssen, Peter J. K. Kuppen, Henk P. J. Buermans, Jelle J. Goeman, Ulrich Nitsche, Hans Morreau, Cornelis J.H. van de Velde, Stefan Böhringer, Remco Derr, Inès J. Goossens-Beumer
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention, 24, 1, pp. 187-97
Cancer Epidemiology, Biomarkers & Prevention, 24, 187-97
Cancer Epidemiology, Biomarkers and Prevention, 24(1), 187-197
Cancer Epidemiology, Biomarkers & Prevention, 24, 187-97
Cancer Epidemiology, Biomarkers and Prevention, 24(1), 187-197
Background: Colon cancer prognosis and treatment are currently based on a classification system still showing large heterogeneity in clinical outcome, especially in TNM stages II and III. Prognostic biomarkers for metastasis risk are warranted as dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ee3323e85764180c11236df5bbc4e2
https://hdl.handle.net/2066/153380
https://hdl.handle.net/2066/153380
Autor:
Inès J. Goossens-Beumer, Peter J. K. Kuppen, Eliane C. M. Zeestraten, Dave S.B. Hoon, Anne Benard, Cornelis J.H. van de Velde, Hein Putter
Publikováno v:
Apoptosis, 19(11), 1581-1593
Deregulation of the apoptotic pathway, one of the hallmarks of tumor growth and -progression, has been shown to have prognostic value for tumor recurrence in rectal cancer. In order to develop clinically relevant bio-markers, we studied the methylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2998e36e70b6c7ff5f8c9e0a7486d81f
https://doi.org/10.1007/s10495-014-1022-z
https://doi.org/10.1007/s10495-014-1022-z
Autor:
Anne Benard, Esther M. de Kruijf, Esther Bastiaannet, N. Geeske Dekker-Ensink, Peter J. K. Kuppen, A. Sajet, Remco Derr, Anneke Q. van Hoesel, Inès J. Goossens-Beumer, Vincent T.H.B.M. Smit, Cornelis J.H. van de Velde
Publikováno v:
BMC Cancer, 14
BMC Cancer
BMC Cancer
Background: Breast cancer is a heterogeneous disease with a highly variable clinical outcome in which both genetic and epigenetic changes have critical roles. We investigated tumor expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b45d41cb5338f0919d47322ea5fb9f4
https://hdl.handle.net/1887/106854
https://hdl.handle.net/1887/106854
Autor:
Anne Benard, Wouter de Graaf, Eliane C. M. Zeestraten, Peter J. K. Kuppen, Hein Putter, Inès J. Goossens-Beumer, Anneke Q. van Hoesel, Hamed Horati, Cornelis J.H. van de Velde
Publikováno v:
BMC Cancer, 14
BMC Cancer
BMC Cancer
Background Post-translational modification of histone tails by methylation plays an important role in tumorigenesis. In this study, we investigated the nuclear expression of H3K4me3, H3K9me3 and H4K20me3 in early-stage colon cancer in relation to cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d3b7a76b7ed52f9c7e17588dba333c
https://doi.org/10.1186/1471-2407-14-531
https://doi.org/10.1186/1471-2407-14-531
Autor:
Marlies S. Reimers, A.L. Vahrmeijer, Eliane C. M. Zeestraten, Hans Morreau, T Christen, G.J. Liefers, Hein Putter, Anne Benard, Cornelis F. M. Sier, Peter J. K. Kuppen, C.J.H. van de Velde, R. Keijzer, Inès J. Goossens-Beumer
Publikováno v:
British Journal of Cancer
British Journal of Cancer, 110(12), 2935-2944
British Journal of Cancer, 110(12), 2935-2944
Background: Tumour aggressiveness might be related to the degree of main cancer hallmark acquirement of tumour cells, reflected by expression levels of specific biomarkers. We investigated the expression of Aldh1, Survivin, and EpCAM, together reflec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a91f2e91cee5d33038402ffdaf1c567
https://hdl.handle.net/1887/106877
https://hdl.handle.net/1887/106877
Autor:
Anneke Q. van Hoesel, Hein Putter, Anne Benard, Inès J. Goossens-Beumer, Hamed Horati, Cornelis J.H. van de Velde, Peter J. K. Kuppen, Eliane C. M. Zeestraten
Publikováno v:
PLoS ONE
PLoS ONE, 9(9)
PLoS ONE, Vol 9, Iss 9, p e108265 (2014)
PLoS ONE, 9(9)
PLoS ONE, Vol 9, Iss 9, p e108265 (2014)
Numerous changes in epigenetic mechanisms have been described in various types of tumors. In search for new biomarkers, we investigated the expression of Polycomb-group (PcG) proteins EZH2, BMI1 and SUZ12 and associated histone modification H3K27me3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785791fba3a49426fb213faf868e477c
https://pubmed.ncbi.nlm.nih.gov/25243792
https://pubmed.ncbi.nlm.nih.gov/25243792
Autor:
Max M. van Noesel, Jules P.P. Meijerink, Dominique J. P. M. Stumpel, Renee X de Menezes, Floor A.M. Duijkers, Inès J. Goossens-Beumer, Pieter Admiraal, Rob Pieters
Publikováno v:
Cellular Oncology, 36(5), 351-362. IOS Press BV
Cellular Oncology, 36(5), 351-362. IOS Press
Duijkers, F A M, Menezes, R, Goossens-Beumer, I J, Stumpel, D J P M, Admiraal, P, Pieters, R, Meijerink, J P P & van Noesel, M M 2013, ' Epigenetic drug combination induces genome-wide demethylation and altered gene expression in neuro-ectodermal tumor-derived cell lines ', Cellular Oncology, vol. 36, no. 5, pp. 351-362 . https://doi.org/10.1007/s13402-013-0140-x
Cellular Oncology, 36(5), 351-362. IOS Press
Duijkers, F A M, Menezes, R, Goossens-Beumer, I J, Stumpel, D J P M, Admiraal, P, Pieters, R, Meijerink, J P P & van Noesel, M M 2013, ' Epigenetic drug combination induces genome-wide demethylation and altered gene expression in neuro-ectodermal tumor-derived cell lines ', Cellular Oncology, vol. 36, no. 5, pp. 351-362 . https://doi.org/10.1007/s13402-013-0140-x
Epigenetic alterations are inherent to cancer cells, and epigenetic drugs are currently primarily used to treat hematological malignancies. Pediatric neuro-ectodermal tumors originate from neural crest cells and also exhibit epigenetic alterations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8136aa9911b1736757d4b01e06e8be60
https://pure.eur.nl/en/publications/bef03e81-27f7-40e4-9a4a-f4a6fc164209
https://pure.eur.nl/en/publications/bef03e81-27f7-40e4-9a4a-f4a6fc164209