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Autor:
Alex Mas Monteys, Haim Burstein, Brian L. Gilmore, Barry A. Polisky, Ryan L. Boudreau, Jodi L. McBride, Barrie J. Carter, Richard W. Peluso, Beverly L. Davidson, Scott Q. Harper, Inâs Martins, Patrick D. Staber
Publikováno v:
Proceedings of the National Academy of Sciences. 105:5868-5873
Huntington's disease (HD) is a fatal, dominant neurodegenerative disease caused by a polyglutamine repeat expansion in exon 1 of the HD gene, which encodes the huntingtin protein. We and others have shown that RNAi is a candidate therapy for HD becau