Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Imre Mäger"'
Autor:
Britt Hanson, Ioulia Vorobieva, Wenyi Zheng, Mariana Conceição, Yulia Lomonosova, Imre Mäger, Pier Lorenzo Puri, Samir El Andaloussi, Matthew J.A. Wood, Thomas C. Roberts
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 511-528 (2023)
Extracellular vesicles (EVs) have been implicated in the regulation of myogenic differentiation. C2C12 murine myoblast differentiation was reduced following treatment with GW4869 or heparin (to inhibit exosome biogenesis and EV uptake, respectively).
Externí odkaz:
https://doaj.org/article/dbfffb011eea4b189072c8015fdf36f1
Autor:
Ghulam Hassan Dar, Cláudia C. Mendes, Wei-Li Kuan, Alfina A. Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J. Lobo, Wooi F. Lim, Samir EL Andaloussi, Imre Mäger, Thomas C. Roberts, Roger A. Barker, Deborah C. I. Goberdhan, Clive Wilson, Matthew J. A. Wood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
GAPDH is generally considered a housekeeping gene and functions in glycolysis. Here, the authors show that GAPDH has a role in promoting vesicle clustering in endosomes and can load siRNA onto the surface of extracellular vesicles, which can be explo
Externí odkaz:
https://doaj.org/article/b286aa9a491c4fbfb8a3ac8161e8f868
Autor:
Olivier G. de Jong, Daniel E. Murphy, Imre Mäger, Eduard Willms, Antonio Garcia-Guerra, Jerney J. Gitz-Francois, Juliet Lefferts, Dhanu Gupta, Sander C. Steenbeek, Jacco van Rheenen, Samir El Andaloussi, Raymond M. Schiffelers, Matthew J. A. Wood, Pieter Vader
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Extracellular vesicles (EV) facilitate intercellular transfer of biological material including RNA, but the regulatory mechanisms for their formation and transfer are incompletely known. Here the authors develop a CRISPR-based reporting system to det
Externí odkaz:
https://doaj.org/article/1db2023ed1d94f558ace5b4d70bad252
Autor:
Emily Feneberg, David Gordon, Alexander G. Thompson, Mattéa J. Finelli, Ruxandra Dafinca, Ana Candalija, Philip D. Charles, Imre Mäger, Matthew J. Wood, Roman Fischer, Benedikt M. Kessler, Elizabeth Gray, Martin R. Turner, Kevin Talbot
Publikováno v:
Neurobiology of Disease, Vol 144, Iss , Pp 105050- (2020)
TDP-43 pathology is a key feature of amyotrophic lateral sclerosis (ALS), but the mechanisms linking TDP-43 to altered cellular function and neurodegeneration remain unclear. We have recently described a mouse model in which human wild-type or mutant
Externí odkaz:
https://doaj.org/article/d8e57a13e21d47cfb4d7b1b8b23465d9
Autor:
Ghulam Hassan Dar, Cláudia C. Mendes, Wei-Li Kuan, Alfina A. Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J. Lobo, Wooi F. Lim, Samir EL Andaloussi, Imre Mäger, Thomas C. Roberts, Roger A. Barker, Deborah C. I. Goberdhan, Clive Wilson, Matthew J. A. Wood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/cd863df03b094f24b93fa9ac4d906638
Autor:
David Roig-Carles, Eduard Willms, Ruud D. Fontijn, Sarai Martinez-Pacheco, Imre Mäger, Helga E. de Vries, Mark Hirst, Basil Sharrack, David K. Male, Cheryl A. Hawkes, Ignacio A. Romero
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1525 (2021)
Blood–brain barrier (BBB) dysfunction is a key hallmark in the pathology of many neuroinflammatory disorders. Extracellular vesicles (EVs) are lipid membrane-enclosed carriers of molecular cargo that are involved in cell-to-cell communication. Circ
Externí odkaz:
https://doaj.org/article/156d140026404c3db3299f560c69e3be
Autor:
Helena Sork, Mariana Conceicao, Giulia Corso, Joel Nordin, Yi Xin Fiona Lee, Kaarel Krjutskov, Jakub Orzechowski Westholm, Pieter Vader, Marie Pauwels, Roosmarijn E. Vandenbroucke, Matthew JA Wood, Samir EL Andaloussi, Imre Mäger
Publikováno v:
Cells, Vol 10, Iss 6, p 1543 (2021)
The extracellular environment consists of a plethora of molecules, including extracellular miRNA that can be secreted in association with extracellular vesicles (EVs) or soluble protein complexes (non-EVs). Yet, interest in therapeutic short RNA carr
Externí odkaz:
https://doaj.org/article/ae8e38fcc6d84a959bd9d3253b00dd47
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Multiple Sclerosis is a demyelinating disease of the central nervous system for which no remyelination therapy is available and alternative strategies are being tested. Extracellular vesicles (EVs) have emerged as players in physiological and patholo
Externí odkaz:
https://doaj.org/article/7207253b2c284d54b0441d64999698b9
Autor:
Olivier G. de Jong, Daniel E. Murphy, Imre Mäger, Eduard Willms, Antonio Garcia-Guerra, Jerney J. Gitz-Francois, Juliet Lefferts, Dhanu Gupta, Sander C. Steenbeek, Jacco van Rheenen, Samir El Andaloussi, Raymond M. Schiffelers, Matthew J. A. Wood, Pieter Vader
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/c79299af34a74ba6b50b6a6e5e719242
Autor:
Iñaki Osorio-Querejeta, Susana Carregal-Romero, Ana Ayerdi-Izquierdo, Imre Mäger, Leslie A. Nash, Matthew Wood, Ander Egimendia, M. Betanzos, Ainhoa Alberro, Leire Iparraguirre, Laura Moles, Irantzu Llarena, Marco Möller, Felipe Goñi-de-Cerio, Goran Bijelic, Pedro Ramos-Cabrer, Maider Muñoz-Culla, David Otaegui
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 186 (2020)
Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally
Externí odkaz:
https://doaj.org/article/d73c9ec6b1f24ebb90b08db73eea60fe