RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shortening

Autor: Shrestha Ghosh, Mileena T. Nguyen, Ha Eun Choi, Maximilian Stahl, Annemarie Luise Kühn, Sandra Van der Auwera, Hans J. Grabe, Henry Völzke, Georg Homuth, Samuel A. Myers, Cory M. Hogaboam, Imre Noth, Fernando J. Martinez, Gregory A. Petsko, Laurie H. Glimcher

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Telomere shortening is a prominent hallmark of aging and is emerging as a characteristic feature of Myelodysplastic Syndromes (MDS) and Idiopathic Pulmonary Fibrosis (IPF). Optimal telomerase activity prevents progressive shortening of telom

Externí odkaz: https://doaj.org/article/acac83437afc458ea79c24761644c96b

Mycophenolate and azathioprine efficacy in interstitial lung disease: a systematic review and meta-analysis

Autor: Sally Singh, Mark Jones, Michael Kreuter, Maria Molina-Molina, Imre Noth, Andrew Wilson, Martin Brutsche, Naftali Kaminski, Gary M Hunninghake, Michael Keane, Nazia Chaudhuri, Ian Forrest, Bruno Crestani, Fernando J Martinez, Mohsen Sadatsafavi, Luca Richeldi, Antje Prasse, Fasihul Khan, Iain Stewart, Steve Jones, Gisli Jenkins, Gauri Saini, David Turner, Killian Hurley, Lucilla Piccari, Andrew Palmer, Joseph A Lasky, Simon Hart, Joyce Lee, Anthony Gordon, John Blaikley, Kirsty Hett, Helmut Prosch, Elisabeth Bendstrup, Christopher Huntley, Helen Parfrey, Huzaifa Adamali, Paul Beirne, Stephen Bianchi, George Chalmers, Sophie Fletcher, Peter George, Michael Gibbons, Mark Spears, Laura Fabbri, Felix Chua, Michael Henry, Cormac McCarthy, Sabrina Paganoni, Joseph Jacob, Mark Toshner, Bibek Gooptu, Andrew Briggs, Philip L Molyneaux, Athol Wells, Charlotte Summers, Leticia Kawano-Dourado, Ian Glaspole, Melanie Quintana, Christopher J Ryerson, Paolo Spagnolo, Francesco Bonella, Carisi Anne Polanczyk, Anjali Crawshaw, Laurence Pearmain, Avinash Anil Nair, Raphaël Borie, Alexandre Biasi Cavalcanti, Emanuela Falaschetti, Jonathan Chung, James Eaden, Kate Johnson, Shaney Barratt, Chris Ryerson, Juergen Behr, Andreas Guenther, Nik Hirani, Karin Storrer, Deepak Talwar, Claudia Ravaglia, Katerina Antoniou, Sara Freitas, Carlo Vancheri, Laura Price, Amanda Goodwin, Daniel Chambers, Gunnar Gudmundsson, Roger Lewis, Ingrid Cox, Anne Holland, Erica Farrand, Argyrios Tzouvelekis, Rui Rolo, Duncan Richards, Larissa Schwarzkopf, Sabina Guler, Devesh Dhasmana, Claudia Valenzuela, John S Kim, Louise Crowley, Lisa Watson, Amanda Bravery, Elisabetta Balestro, Wendy Adams, Francesco Lombardi, Ali Mojibian, Ana Etges, Ana Sousa Marcelino Boshoff, Anne Bergeron Anna-MariaHoffmann-Vold, Athina Trachalaki, Barbara Wendelberger, Bhavika Kaul Ben Hope-Gill, Bruno Baldi, Carlos Robalo, Chris Grainge, Christophe von Garnier, Conal Hayton, Dapeng Wang, Daphne Bablis, David Thicket, Deji Adegunsoye, Devaraj Anand, Dhruv Parek, Diane Griffiths, Eliana Santucci, Eliza Tsitoura, Emma Karlsen, Ena Gupta, Harold Collard, Hernan Fainberg, Iazsmin Bauer-Ventura, Irina Strambu, Jacobo Sellares, Janet Johnston, Jeff Swigris, Karina Negrelli, Katarzyna Lewandowska, Katrin Hostettler, Kerri Johannson, Liam Galvin, Lisa G. Spencer, Manuela Funke Chambour, Marlies Wijsenbeek-Lourens, Martina Vasakova, Milena Man Iuliu Hatieganu, Nick Weatherley, Ovidiu Fira Mladinescu Victor Babes, Peter Bryce, Pilar Rivera Ortega, Radu Crisan-Dabija, Rahul Maida, Sara Piciucchi, Shama Malik, Simone Dal Corso, Stefan Stanel

Publikováno v: BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)

Objectives Mycophenolate mofetil (MMF) and azathioprine (AZA) are immunomodulatory treatments in interstitial lung disease (ILD). This systematic review aimed to evaluate the efficacy of MMF or AZA on pulmonary function in ILD.Design Population inclu

Externí odkaz: https://doaj.org/article/2ac47dada7d648a4a2a2a9b8b2f6ab10

Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

Autor: Pei-Ying Wu, Michelle Van Scoyk, Stephanie S. McHale, Chu-Fang Chou, Gregory Riddick, Kamran Farouq, Bin Hu, Vita Kraskauskiene, Jennifer Koblinski, Charles Lyons, Arjun Rijal, Vignesh Vudatha, Dongyu Zhang, Jose G. Trevino, Rachit D. Shah, Patrick Nana-Sinkam, Yong Huang, Shwu-Fan Ma, Imre Noth, Chanita Hughes-Halbert, Victoria L. Seewaldt, Ching-Yi Chen, Robert A. Winn

Publikováno v: iScience, Vol 27, Iss 2, Pp 108858- (2024)

Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinan

Externí odkaz: https://doaj.org/article/2b1b617e9e464c16a2b0c6f8fca1416f

Central lung gene expression associates with myofibroblast features in idiopathic pulmonary fibrosis

Autor: Imre Noth, Yong Huang, Aliya N Husain, Shwu-Fan Ma, Jonathan Jou, Rob Guzy, Catherine A Bonham, Jefree J Schulte, John S Kim, Andrew J Barros, Milena S Espindola, Cory M Hogaboam, Anne I Sperling

Publikováno v: BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)

Rationale Contribution of central lung tissues to pathogenesis of idiopathic pulmonary fibrosis (IPF) remains unknown.Objective To ascertain the relationship between cell types of IPF-central and IPF-peripheral lung explants using RNA sequencing (RNA

Externí odkaz: https://doaj.org/article/8ec06459ed0948489a762ccc76c5dcd7

Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts

Autor: Ayodeji Adegunsoye, Chad A. Newton, Justin M. Oldham, Brett Ley, Cathryn T. Lee, Angela L. Linderholm, Jonathan H. Chung, Nicole Garcia, Da Zhang, Rekha Vij, Robert Guzy, Renea Jablonski, Remzi Bag, Rebecca S. Voogt, Shwu-Fan Ma, Anne I. Sperling, Ganesh Raghu, Fernando J. Martinez, Mary E. Strek, Paul J. Wolters, Christine Kim Garcia, Brandon L. Pierce, Imre Noth

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

The association of telomere length with age and mortality across racially diverse pulmonary fibrosis populations is unknown. Here, the authors show that leukocyte telomere length associates with chronologic age and is predictive of mortality in pulmo

Externí odkaz: https://doaj.org/article/0bc191d2efb44548bed2e6c7dc646b0c