Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Imran S. Khan"'
Autor:
Todd C. Metzger, Imran S. Khan, James M. Gardner, Maria L. Mouchess, Kellsey P. Johannes, Anna K. Krawisz, Katarzyna M. Skrzypczynska, Mark S. Anderson
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 166-179 (2013)
Thymic epithelial cells in the medulla (mTECs) play a critical role in enforcing central tolerance through expression and presentation of tissue-specific antigens (TSAs) and deletion of autoreactive thymocytes. TSA expression requires autoimmune regu
Externí odkaz:
https://doaj.org/article/0bcb43b5b7ce4ed0b3aeaddfe559da99
Autor:
Imran S. Khan, Tursun Ablekim, Deborah L. McGott, Brian Good, Craig L. Perkins, Wyatt K. Metzger, Andriy Zakutayev
Publikováno v:
Solar RRL. 6:2200394
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d91e38aaab38154bf52f07e9c2c50cc6
https://doi.org/10.1002/solr.202200394
https://doi.org/10.1002/solr.202200394
Autor:
Mark S. Anderson, Richard M. Locksley, Lars M. Steinmetz, Corey N. Miller, Joshua L. Pollack, Wint Lwin, Imran S. Khan, Todd C. Metzger, Bruno Kyewski, Aparna R. Rajpurkar, David J. Erle, Kristin Rattay, Irina Proekt, Adam Fries, Haiguang Wang, Kristen L. Wells, Jakob von Moltke, Kristin A. Hogquist, Audrey Parent, Eric J. Wigton
Publikováno v:
Nature
The thymus is responsible for generating a diverse yet self-tolerant pool of T cells1. Although the thymic medulla consists mostly of developing and mature AIRE+ epithelial cells, recent evidence has suggested that there is far greater heterogeneity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b83fbf8c06bb9b601feea89ea054b4d
http://europepmc.org/articles/PMC6062473
http://europepmc.org/articles/PMC6062473
Autor:
Imran S. Khan
Publikováno v:
Nature. 595:650-650
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64ee216fe97383b4af587d0229b278f
https://doi.org/10.1038/d41586-021-02046-z
https://doi.org/10.1038/d41586-021-02046-z
Autor:
Lee Kyung Hong, David Sailer, Ajay S. Gulati, Imran S. Khan, Joshua Starmer, Pearl Bakhru, Lawrence Fong, Fengmin Zhao, Sandra J. Lee, Maureen A. Su, Stergios J. Moschos, Maria L. Mouchess, Meng-Lei Zhu, John M. Kirkwood, Mark S. Anderson, Yafei Hou, Hsing-Hui Wang
Publikováno v:
JCI insight, vol 2, iss 18
Blockade of immune checkpoint proteins (e.g., CTLA-4, PD-1) improves overall survival in advanced melanoma; however, therapeutic benefit is limited to only a subset of patients. Because checkpoint blockade acts by "removing the brakes" on effector T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32aec97d693d186815b4ee207acc096e
https://escholarship.org/uc/item/7ms747qt
https://escholarship.org/uc/item/7ms747qt
Autor:
Maureen A. Su, Kayla J. Fasano, Maria L. Mouchess, Yafei Hou, Lawrence Fong, Bridget Conley, Imran S. Khan, Meng-Lei Zhu, Mark S. Anderson
Publikováno v:
The Journal of Experimental Medicine
Modulation of central tolerance through RANKL alters thymic output and enhances anti-tumor immunity.
Thymic central tolerance is a critical process that prevents autoimmunity but also presents a challenge to the generation of anti-tumor immune r
Thymic central tolerance is a critical process that prevents autoimmunity but also presents a challenge to the generation of anti-tumor immune r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98899257bd1b16b83fa254e3aa4c9653
https://doi.org/10.1084/jem.20131889
https://doi.org/10.1084/jem.20131889
Publikováno v:
Nucleic Acids Research
Deficiency in Artemis is associated with lack of V(D)J recombination, sensitivity to radiation and radiomimetic drugs, and failure to repair a subset of DNA double-strand breaks (DSBs). Artemis harbors an endonuclease activity that trims both 5'- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453503f5ff98715044f36dcd69dfd39e
https://doi.org/10.1093/nar/gkr257
https://doi.org/10.1093/nar/gkr257
Publikováno v:
European journal of immunology, vol 44, iss 5
EUROPEAN JOURNAL OF IMMUNOLOGY
EUROPEAN JOURNAL OF IMMUNOLOGY
Medullary thymic epithelial cells (mTECs) facilitate the deletion of developing self-reactive T cells by displaying a diverse repertoire of tissue-specific antigens, a process which largely depends on the expression of the autoimmune regulator (Aire)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cfc444dcb7ef7daaa00ee8e71a27f2
https://europepmc.org/articles/PMC4141217/
https://europepmc.org/articles/PMC4141217/
Autor:
Alexandra M. Greer, Michael Waterfield, Joshua L. Pollack, David J. Erle, Una Fan, Marc Martinez-Llordella, Kayla J. Fasano, Imran S. Khan, Todd C. Metzger, Mark S. Anderson, Maureen A. Su, Jessica T. Cortez
Publikováno v:
Nature immunology. 15(3)
The maintenance of immune tolerance requires the deletion of self-reactive T cells in the thymus. The expression of tissue-specific antigen genes (TSAs) by thymic epithelial cells is critical for this process and depends on the activity of the Autoim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e775da41fa54947391fe9259fe03813
https://pubmed.ncbi.nlm.nih.gov/24464130
https://pubmed.ncbi.nlm.nih.gov/24464130
Autor:
Imran S. Khan, Taylor N. LaFlam, Holger A. Russ, Audrey Parent, Todd C. Metzger, Matthias Hebrok, Mark S. Anderson
Publikováno v:
Cell stem cell, vol 13, iss 2
Inducing immune tolerance to prevent rejection is a key step toward successful engraftment of stem-cell-derived tissue in a clinical setting. Using human pluripotent stem cells to generate thymic epithelial cells (TECs) capable of supporting Tcell de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128e5f283207f3fd1b7d8fd17247c016
https://pubmed.ncbi.nlm.nih.gov/23910077
https://pubmed.ncbi.nlm.nih.gov/23910077