Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Imran G. House"'
Autor:
Kirsten L. Todd, Junyun Lai, Kevin Sek, Yu-Kuan Huang, Dane M. Newman, Emily B. Derrick, Hui-Fern Koay, Dat Nguyen, Thang X. Hoang, Emma V. Petley, Cheok Weng Chan, Isabelle Munoz, Imran G. House, Joel N. Lee, Joelle S. Kim, Jasmine Li, Junming Tong, Maria N. de Menezes, Christina M. Scheffler, Kah Min Yap, Amanda X. Y. Chen, Phoebe A. Dunbar, Brandon Haugen, Ian A. Parish, Ricky W. Johnstone, Phillip K. Darcy, Paul A. Beavis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been developed for targeting the A2AR receptor. Understanding of the mechanism by which A2AR is regulated
Externí odkaz:
https://doaj.org/article/b9c76314c12142099494e8759d06a025
Autor:
Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X.Y. Chen, Jasmine Li, Junyun Lai, Kirsten L. Todd, Isabelle Munoz, Jessica Michie, Cheok Weng Chan, Yu-Kuan Huang, Jack D. Chan, Emma V. Petley, Junming Tong, DatMinh Nguyen, Sven Engel, Peter Savas, Simon J. Hogg, Stephin J. Vervoort, Conor J. Kearney, Marian L. Burr, Enid Y.N. Lam, Omer Gilan, Sammy Bedoui, Ricky W. Johnstone, Mark A. Dawson, Sherene Loi, Phillip K. Darcy, Paul A. Beavis
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113793- (2024)
Externí odkaz:
https://doaj.org/article/3bc9e9ff1e6348e1add4deb56de520ff
Autor:
Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X.Y. Chen, Jasmine Li, Junyun Lai, Kirsten L. Todd, Isabelle Munoz, Jessica Michie, Cheok Weng Chan, Yu-Kuan Huang, Jack D. Chan, Emma V. Petley, Junming Tong, DatMinh Nguyen, Sven Engel, Peter Savas, Simon J. Hogg, Stephin J. Vervoort, Conor J. Kearney, Marian L. Burr, Enid Y.N. Lam, Omer Gilan, Sammy Bedoui, Ricky W. Johnstone, Mark A. Dawson, Sherene Loi, Phillip K. Darcy, Paul A. Beavis
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 113014- (2023)
Summary: CXCL9 expression is a strong predictor of response to immune checkpoint blockade therapy. Accordingly, we sought to develop therapeutic strategies to enhance the expression of CXCL9 and augment antitumor immunity. To perform whole-genome CRI
Externí odkaz:
https://doaj.org/article/36f8c10bf54b436e8b3737f736a4464b
Autor:
Emma V. Petley, Hui-Fern Koay, Melissa A. Henderson, Kevin Sek, Kirsten L. Todd, Simon P. Keam, Junyun Lai, Imran G. House, Jasmine Li, Magnus Zethoven, Amanda X. Y. Chen, Amanda J. Oliver, Jessica Michie, Andrew J. Freeman, Lauren Giuffrida, Jack D. Chan, Angela Pizzolla, Jeffrey Y. W. Mak, Timothy R. McCulloch, Fernando Souza-Fonseca-Guimaraes, Conor J. Kearney, Rosemary Millen, Robert G. Ramsay, Nicholas D. Huntington, James McCluskey, Jane Oliaro, David P. Fairlie, Paul J. Neeson, Dale I. Godfrey, Paul A. Beavis, Phillip K. Darcy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enha
Externí odkaz:
https://doaj.org/article/01f893fc7b8b403cadf95ab8ec274a3e
Autor:
Lauren Giuffrida, Kevin Sek, Melissa A. Henderson, Junyun Lai, Amanda X. Y. Chen, Deborah Meyran, Kirsten L. Todd, Emma V. Petley, Sherly Mardiana, Christina Mølck, Gregory D. Stewart, Benjamin J. Solomon, Ian A. Parish, Paul J. Neeson, Simon J. Harrison, Lev M. Kats, Imran G. House, Phillip K. Darcy, Paul A. Beavis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activation of the adenosine receptor A2AR is associated with suppression of T cell function in the tumor microenvironment. To overcome immunosuppression, here the authors show that CRISPR/Cas9 mediated deletion of A2AR enhances CAR T cell effector fu
Externí odkaz:
https://doaj.org/article/483b1c1b715b445cad3cbef377ef8466
Autor:
Phillip K. Darcy, Nicole M. Haynes, Michael H. Kershaw, Sherene Loi, Joseph A. Trapani, Clare Y. Slaney, Sherly Mardiana, Liza B. John, Nicole Milenkovski, Kevin Sek, Junyun Lai, Imran G. House, Emma V. Petley, Alexander J. Davenport, Lauren Giuffrida, Melissa A. Henderson, Paul A. Beavis
Supplementary Figure 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa70920f2ea2ffa82c316b0ad43d943
https://doi.org/10.1158/2326-6066.22540024
https://doi.org/10.1158/2326-6066.22540024
Autor:
Phillip K. Darcy, Nicole M. Haynes, Michael H. Kershaw, Sherene Loi, Joseph A. Trapani, Clare Y. Slaney, Sherly Mardiana, Liza B. John, Nicole Milenkovski, Kevin Sek, Junyun Lai, Imran G. House, Emma V. Petley, Alexander J. Davenport, Lauren Giuffrida, Melissa A. Henderson, Paul A. Beavis
Immunotherapy is widely accepted as a powerful new treatment modality for the treatment of cancer. The most successful form of immunotherapy to date has been the blockade of the immune checkpoints PD-1 and CTLA-4. Combining inhibitors of both PD-1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06613cc65779fd52877cccabc16a12c3
https://doi.org/10.1158/2326-6066.c.6549253.v1
https://doi.org/10.1158/2326-6066.c.6549253.v1
Autor:
Paul A. Beavis, Phillip K. Darcy, Sherene Loi, James S. Wilmott, Georgina V. Long, Richard A. Scolyer, Camelia Quek, Tuba N. Gide, Sherly Mardiana, Kevin Sek, Emma V. Petley, Lauren Giuffrida, Melissa A. Henderson, Kirsten L. Todd, Zhi L. Teo, Amanda J. Oliver, Amanda X.Y. Chen, Junyun Lai, Peter Savas, Imran G. House
Figure S7 shows the gene expression profile of macrophages and other immune cell subsets in cancer patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4753ba22a8ce0f48e083a56e502d3e35
https://doi.org/10.1158/1078-0432.22474361.v1
https://doi.org/10.1158/1078-0432.22474361.v1
Autor:
Paul A. Beavis, Phillip K. Darcy, Sherene Loi, James S. Wilmott, Georgina V. Long, Richard A. Scolyer, Camelia Quek, Tuba N. Gide, Sherly Mardiana, Kevin Sek, Emma V. Petley, Lauren Giuffrida, Melissa A. Henderson, Kirsten L. Todd, Zhi L. Teo, Amanda J. Oliver, Amanda X.Y. Chen, Junyun Lai, Peter Savas, Imran G. House
Purpose:Response rates to immune checkpoint blockade (ICB; anti-PD-1/anti-CTLA-4) correlate with the extent of tumor immune infiltrate, but the mechanisms underlying the recruitment of T cells following therapy are poorly characterized. A greater und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c4499e75b902884c1838af5b217009
https://doi.org/10.1158/1078-0432.c.6528764.v1
https://doi.org/10.1158/1078-0432.c.6528764.v1
Autor:
Paul A. Beavis, Phillip K. Darcy, Sherene Loi, James S. Wilmott, Georgina V. Long, Richard A. Scolyer, Camelia Quek, Tuba N. Gide, Sherly Mardiana, Kevin Sek, Emma V. Petley, Lauren Giuffrida, Melissa A. Henderson, Kirsten L. Todd, Zhi L. Teo, Amanda J. Oliver, Amanda X.Y. Chen, Junyun Lai, Peter Savas, Imran G. House
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801da0d12f8a87c9458be6fe935bcc0c
https://doi.org/10.1158/1078-0432.22474358
https://doi.org/10.1158/1078-0432.22474358