Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Imran A. Bhutto"'
Autor:
Peng Shang, Nadezda Stepicheva, Kenneth Teel, Austin McCauley, Christopher Scott Fitting, Stacey Hose, Rhonda Grebe, Meysam Yazdankhah, Sayan Ghosh, Haitao Liu, Anastasia Strizhakova, Joseph Weiss, Imran A. Bhutto, Gerard A. Lutty, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, J. Samuel Zigler, James T. Handa, Yuri Sergeev, Raju V. S. Rajala, Simon Watkins, Debasish Sinha
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Shang et al. utilize a conditional Cryba1 knockout mouse model to demonstrate a key role for βA3/A1-crystallin in retinal pigmented epithelium. As a result of βA3/A1-crystallin deficiency, the authors report EGFR endocytosis defects and actin netwo
Externí odkaz:
https://doaj.org/article/601fb7f3dfa3458993f6399da1134e8f
Autor:
Sayan Ghosh, Haitao Liu, Meysam Yazdankhah, Nadezda Stepicheva, Peng Shang, Tanuja Vaidya, Stacey Hose, Urvi Gupta, Michael Joseph Calderon, Ming-Wen Hu, Archana Padmanabhan Nair, Joseph Weiss, Christopher S. Fitting, Imran A. Bhutto, Santosh Gopi Krishna Gadde, Naveen Kumar Naik, Chaitra Jaydev, Gerard A. Lutty, James T. Handa, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, Dhivyaa Rajasundaram, Yuri Sergeev, J. Samuel Zigler, Swaminathan Sethu, Simon Watkins, Arkasubhra Ghosh, Debasish Sinha
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
Ghosh et al. show that a lens protein βA1-crystallin inhibits PTP1B activity, regulating the metabolism of retinal astrocytes. They find that knockdown of βA1-crystallin exacerbates the streptozotocin-induced diabetic retinopathy-like phenotype in
Externí odkaz:
https://doaj.org/article/73f2d2042a5b442cb0991f9ae494dfe7
Autor:
Malia M. Edwards, D. Scott McLeod, Mengxi Shen, Rhonda Grebe, Janet S. Sunness, Imran A. Bhutto, Erin McDonnell, Alexandra M. Pado, Giovanni Gregori, Philip J. Rosenfeld, Gerard A. Lutty
Publikováno v:
Investigative Opthalmology & Visual Science. 64:2
Autor:
Michael I. Barbato, Imran Ahmed Bhutto, Riya Kanherkar, Ludovic Zimmerlin, Justin Thomas, Jeffrey S. Huo, Elias T. Zambidis, Nensi Ruzgar, Tea Soon Park, G. A. Lutty, Rhonda Grebe, Michael A. Koldobskiy, Rebecca Evans-Moses, Alice He
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
Here, we report that the functionality of vascular progenitors (VP) generated from normal and disease-primed conventional human induced pluripotent stem cells (hiPSC) can be significantly improved by reversion to a tankyrase inhibitor-regulated human
Autor:
Tomohiro Nizawa, Imran A. Bhutto, Anupama Tiwari, Rhonda R. Grebe, Jesse Alt, Rana Rais, Malia M. Edwards, Gerard A. Lutty
Publikováno v:
Translational Vision Science & Technology
Purpose This study evaluates whether topical ketotifen fumarate (KTF) can prevent geographic atrophy (GA)-like phenotypes in a rat model. Methods Pharmacokinetics (PKs) of KTF after topical administration twice daily for 5 days was analyzed in rat re
Autor:
Imran Ahmed Bhutto, Tony Wu, Rangaramanujam M. Kannan, D. Scott McLeod, Siva P. Kambhampati, Gerard A. Lutty, Katie Ho
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 335
Inflammation and neovascularization are key pathological events in human age-related macular degeneration (AMD). Activated microglia/macrophages (mi/ma) and retinal pigmented epithelium (RPE) play an active role in every stage of disease progression.
Autor:
Yuri V. Sergeev, Debasish Sinha, Jiang Qian, Simon C. Watkins, Urvi Gupta, Tanuja Vaidya, Ashwath Jayagopal, Sayan Ghosh, J. Samuel Zigler, Stacey Hose, José-Alain Sahel, Peng Shang, Imran Ahmed Bhutto, Joseph Weiss, Michael J. Calderon, Santosh Gopi Krishna Gadde, Nadezda A. Stepicheva, Gerard A. Lutty, Arkasubhra Ghosh, Ming Wen Hu, Christopher Scott Fitting, Dhivyaa Rajasundaram, Naveen Kumar Naik, James T. Handa, Meysam Yazdankhah, Swaminathan Sethu, Archana Padmanabhan Nair, Chaitra Jaydev, Haitao Liu
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
βA3/A1-crystallin, a lens protein that is also expressed in astrocytes, is produced as βA3 and βA1-crystallin isoforms by leaky ribosomal scanning. In a previous human proteome high-throughput array, we found that βA3/A1-crystallin interacts with
Autor:
Imran Ahmed Bhutto, Rana Rais, Rajkumar Baldeosingh, William Schubert, Donald Scott McLeod, Siva P. Kambhampati, Gerard A. Lutty, Malia Michelle Edwards, Shuntaro Ogura
Publikováno v:
FASEB J
Mast cells (MCs) are the initial responders of innate immunity and their degranulation contribute to various etiologies. While the abundance of MCs in the choroid implies their fundamental importance in the eye, little is known about the significance
Autor:
Nadezda A, Stepicheva, Joseph, Weiss, Peng, Shang, Meysam, Yazdankhah, Sayan, Ghosh, Imran A, Bhutto, Stacey, Hose, J Samuel, Zigler, Debasish, Sinha
Publikováno v:
Advances in experimental medicine and biology. 1185
The association between age-related macular degeneration (AMD) and biological rhythms has been insufficiently studied; however there are several reasons to believe that impairment in circadian rhythm may affect incidence and pathogenesis of AMD. The
Autor:
Charles G. Eberhart, Morton F. Goldberg, Bernhard H. F. Weber, Scott McLeod, Rajkumar Baldeosingh, Imran Ahmed Bhutto, Mark O.M. Tso, Kirk H. Packo, Malia Michelle Edwards, Gerard A. Lutty
Publikováno v:
Ophthalmology Retina. 2:360-378
Purpose To assess the immunohistochemical and histopathologic changes in a subject with autosomal dominant vitreoretinochoroidopathy (ADVIRC). Design Research manuscript. Participant A 92-year-old white man with ADVIRC. Methods The subject was docume