Výsledky vyhledávání - "Impellizzeri, Agata Antonina Rita"

Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis

Autor: Impellizzeri, Agata Antonina Rita, Pappalardo, Matteo, Basile, Livia, Manfra, Ornella, Andressen, Kjetil Wessel, Krobert, Kurt Allen, Messina, Angela, Levy, Finn Olav, Guccione, Salvatore

Publikováno v: Frontiers in Behavioral Neuroscience

The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders. We examined molecular determinants of ligand binding and G protein activation by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d15aba460337e5355a29a5d295894a88
http://europepmc.org/articles/PMC4424842

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Site-directed mutagenesis and molecular modeling studies of h5-HT7(a) receptor reveal important residues for binding and activation

Autor: Impellizzeri, Agata Antonina Rita

Serotonin (5-hydroxytryptamine, 5-HT) is a key neurotransmitter implicated in neuropsychiatric disturbance such as depression, anxiety and psychosis. Recent studies on knockout animals and using selective 5-HT7 receptor antagonists have provided stro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2357::2290c83f05e20446f3a33c5b56ccbf78
https://hdl.handle.net/10761/1169

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Akademický článek

Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis.

Autor: Impellizzeri, Agata Antonina Rita, Pappalardo, Matteo, Basile, Livia, Manfra, Ornella, Wessel Andressen, Kjetil, Krobert, Kurt Allen, Messina, Angela, Olav Levy, Finn, Guccione, Salvatore

Publikováno v: Frontiers in Behavioral Neuroscience; May2015, Vol. 9, p1-12, 12p

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