Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Impaired platelet aggregation"'
Autor:
Frances M. Platt, David Smith, Lauren Morris, Oscar C. W. Chen, Lianne C. Davis, Alexandria Colaco, Emily R. Eden, Forbes D. Porter, Patricia W. Tynan, Fedir N Kiskin, Anneliese O. Speak, Grant C. Churchill, Nicole Y. Farhat, Antony Galione
Publikováno v:
JIMD Reports, Vol 56, Iss 1, Pp 46-57 (2020)
JIMD Reports
JIMD Reports
Niemann‐Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder caused by mutations in either NPC1 (95% of cases) or NPC2. Reduced late endosome/lysosome calcium (Ca2+) levels and the accumulation of unesterified cholesterol and
Autor:
Canan Albayrak, B Koc, Davut Albayrak, F Bianchi, Berkay Saraymen, Emine Zengin, Christophe Chenet, Mustafa Yavuz Köker, Musa Karakukcu, Bulent Zulfikar, Nazan Sarper, V. Jallu, R Petermann, Hüseyin Avcılar, A.G. de Brevern
Publikováno v:
Platelets
Platelets, Taylor & Francis, 2022, 33 (4), pp.551-561. ⟨10.1080/09537104.2021.1947481⟩
Platelets, Taylor & Francis, 2022, 33 (4), pp.551-561. ⟨10.1080/09537104.2021.1947481⟩
Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding disorder characterized by impaired platelet aggregation due to defects in integrin alpha IIb beta 3, a fibrinogen receptor. Platelet phenotypes and allelic variations in 28 Turkish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1de0f6dd347b725a48b111d27b16324
https://avesis.kayseri.edu.tr/publication/details/0c61e85d-cb1c-4134-b43d-3ca233af65f3/oai
https://avesis.kayseri.edu.tr/publication/details/0c61e85d-cb1c-4134-b43d-3ca233af65f3/oai
Autor:
Katrina K Ki, Geoff Tansley, Tomotaka Murashige, Nobuo Watanabe, Masataka Inoue, John F. Fraser, Chris H H Chan, Michael J. Simmonds
Publikováno v:
Artificial Organs
Nonsurgical bleeding is the most frequent complication of left ventricular assist device (LVAD) support. Supraphysiologic shear rates generated in LVAD causes impaired platelet aggregation, which increases the risk of bleeding. The effect of shear ra
Publikováno v:
J Appl Lab Med
Background Platelet dysfunction often accompanies trauma-induced coagulopathy. Because soluble fibrin impairs platelet glycoprotein VI (GPVI) signaling and platelets of trauma patients can display impaired calcium mobilization, we explored the role o
Autor:
Lucy Z. Kornblith, Mitchell J. Cohen, Rachael A. Callcut, Alexander T. Fields, Nichole Starr, Zachary A. Matthay, Brenda Nunez-Garcia
Publikováno v:
J Trauma Acute Care Surg
The journal of trauma and acute care surgery, vol 89, iss 1
The journal of trauma and acute care surgery, vol 89, iss 1
Background Platelet behavior in trauma-induced coagulopathy is poorly understood. Injured patients have impaired platelet aggregation (dysfunction) in ex vivo agonist-stimulated platelet aggregometry (PA). However, PA assumes that platelets are inact
Autor:
Gaël Nicolas, Thierry Peyrard, Mahmoud Mikdar, Slim Azouzi, Patrick Mayeux, Christine Bole-Feysot, Alexandra Willemetz, Olivier Hermine, Cédric Vrignaud, Marc Cloutier, Emilie-Fleur Gautier, Alexandre Raneri, Virginie Salnot, Maryse St-Louis, Caroline Le Van Kim, Jessica Constanzo-Yanez, Jean-Pierre Cartron, Gabriele Jedlitschky, Nancy Robitaille, Carole Éthier, Patricia Hermand, Patrick Nitschke, Yves Colin
Publikováno v:
Blood
Blood, 2019, 135 (6), pp.441-448. ⟨10.1182/blood.2019002320⟩
Blood, American Society of Hematology, 2019, 135 (6), pp.441-448. ⟨10.1182/blood.2019002320⟩
Blood, 2019, 135 (6), pp.441-448. ⟨10.1182/blood.2019002320⟩
Blood, American Society of Hematology, 2019, 135 (6), pp.441-448. ⟨10.1182/blood.2019002320⟩
The rare PEL-negative phenotype is one of the last blood groups with an unknown genetic basis. By combining whole-exome sequencing and comparative global proteomic investigations, we found a large deletion in the ABCC4/MRP4 gene encoding an ATP-bindi
Autor:
Lucy Z. Kornblith, Zachary A. Matthay
Publikováno v:
Current Trauma Reports. 5:202-209
The purpose of this review is to summarize the current understanding of the role of aberrant platelet biology in trauma-induced coagulopathy (TIC), discuss the evidence for platelet transfusions in the management of hemorrhaging trauma patients, and
Publikováno v:
Journal of Clinical Medicine
Volume 10
Issue 10
Journal of Clinical Medicine, Vol 10, Iss 2205, p 2205 (2021)
Volume 10
Issue 10
Journal of Clinical Medicine, Vol 10, Iss 2205, p 2205 (2021)
Blood coagulation disorders in patients with intracranial bleeding as a result of head injuries or ruptured aneurysms are a diagnostic and therapeutic problem and appropriate assessments are needed to limit CNS damage and to implement preventive meas
Autor:
Diego Chacon, Sung K. Chiu, David J. Curtis, Mitchell J. Moon, Stephanie L. Orive, Justin Raymond Hamilton, Cedric S. Tremblay, John E. Pimanda, Dominik Beck, Benjamin T. Kile, Sarah Ellis, Yizhou Huang, Jesslyn Saw
Publikováno v:
Blood. 134:826-835
The stem cell leukemia (Scl or Tal1) protein forms part of a multimeric transcription factor complex required for normal megakaryopoiesis. However, unlike other members of this complex such as Gata1, Fli1, and Runx1, mutations of Scl have not been ob
Autor:
Wolfgang Muntean, Axel Schlagenhauf, Harald Haidl, Sina Pohl, Bettina Leschnik, Siegfried Gallistl
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
Healthy neonates exhibit a well-functioning haemostatic system despite peculiarities regarding composition of clotting factors and inhibitors as well as impaired platelet aggregation. Thrombocytopenia and severe bleeding events are feared in sick inf