Novel MLH1 nonsense variant in a patient with suspected Lynch syndrome.

Autor: Takaiso N; Risk Assessment Unit, Aichi Cancer Center Hospital, Nagoya, Japan., Imoto I; Risk Assessment Unit, Aichi Cancer Center Hospital, Nagoya, Japan. iimoto@aichi-cc.jp.; Aichi Cancer Center Research Institute, Nagoya, Japan. iimoto@aichi-cc.jp., Matsumoto T; Department of Medical Oncology, Ichinomiyanishi Hospital, Ichinomiya, Japan., Yoshimura A; Risk Assessment Unit, Aichi Cancer Center Hospital, Nagoya, Japan.; Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

Publikováno v: Human genome variation [Hum Genome Var] 2024 Sep 17; Vol. 11 (1), pp. 36. Date of Electronic Publication: 2024 Sep 17.

Clinical, genomic and immune microenvironmental determinants of nivolumab response in head and neck squamous cell carcinoma.

Autor: Tsujikawa T; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR, United States., Ohno K; Department of Head and Neck Surgery, Tokyo Medical and Dental University, Tokyo, Japan., Morita KI; Department of Maxillofacial Surgery, Tokyo Medical and Dental University, Tokyo, Japan., Saburi S; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan., Mitsuda J; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan., Yoshimura K; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kimura A; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan., Morimoto H; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ogi H; Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.; SCREEN Holdings, Kyoto, Japan., Shibata S; SCREEN Holdings, Kyoto, Japan., Akashi T; Department of Diagnostic Pathology, Tokyo Medical and Dental University, Tokyo, Japan., Kurata M; Department of Comprehensive Pathology, Tokyo Medical and Dental University, Tokyo, Japan., Imoto I; Aichi Cancer Center Research Institute, Nagoya, Japan., Shimizu Y; Department of Medical Oncology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan., Kano S; Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan., Watanabe A; Department of Otolaryngology- Head and Neck Surgery, Keiyukai Sapporo Hospital, Sapporo, Japan., Yamazaki T; Department Head and Neck Oncology Division, Saitama Medical University International Medical Center, Hidaka, Japan., Asada Y; Department of Head and Neck Surgery, Miyagi Cancer Center, Natori, Japan., Hayashi R; Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan., Saito Y; Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Ozawa H; Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan., Tsukahara K; Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan., Oridate N; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University, School of Medicine, Yokohama, Japan., Sano D; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University, School of Medicine, Yokohama, Japan., Horii A; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Ueki Y; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Maruo T; Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Mukoyama N; Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Hanai N; Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan., Fukusumi T; Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan., Iwai H; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University Hospital, Osaka, Japan., Fujisawa T; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University Hospital, Osaka, Japan., Fujii T; Department of Head and Neck Surgery, Osaka International Cancer Institute, Osaka, Japan., Nibu KI; Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Iwae S; Department of Head and Neck Surgery, Hyogo Cancer Center, Akashi, Japan., Ueda T; Department of Otolaryngology and Head and Neck Surgery, Hiroshima University Hospital, Hiroshima, Japan., Chikuie N; Department of Otolaryngology and Head and Neck Surgery, Hiroshima University Hospital, Hiroshima, Japan., Yasumatsu R; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Kindai University, Osaka, Japan., Matsuo M; Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Umeno H; Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan., Ono T; Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan., Masuda M; Department of Head and Neck Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan., Toh S; Department of Head and Neck Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan., Itoh K; Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Hirano S; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan., Asakage T; Department of Head and Neck Surgery, Tokyo Medical and Dental University, Tokyo, Japan.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Jul 29; Vol. 15, pp. 1390873. Date of Electronic Publication: 2024 Jul 29 (Print Publication: 2024).

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Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.

Autor: Koyanagi YN; Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Namba S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Oze I; Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan., Charvat H; Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan.; Division of International Health Policy Research, Institute for Cancer Control, National Cancer Center, Tokyo, Japan.; Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France., Narita A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Ikezaki H; Department of General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan.; Department of Comprehensive General Internal Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan., Hishida A; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan., Hara M; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan., Takezaki T; Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan., Koyama T; Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan., Nakamura Y; Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan., Suzuki S; Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Katsuura-Kamano S; Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan., Kuriki K; Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan., Nakamura Y; Department of Public Health, Shiga University of Medical Science, Otsu, Japan., Takeuchi K; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of International and Community Oral Health, Tohoku University Graduate School of Dentistry, Sendai, Japan.; Division for Regional Community Development, Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan., Hozawa A; Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Kinoshita K; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Sutoh Y; Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Tanno K; Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Iwate, Japan.; Division of Clinical Research and Epidemiology, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Shimizu A; Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.; Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Iwate, Japan., Ito H; Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Kasugai Y; Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Kawakatsu Y; Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan., Taniyama Y; Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan., Tajika M; Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan., Shimizu Y; Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan., Suzuki E; Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hosono Y; Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Imoto I; Aichi Cancer Center Research Institute, Nagoya, Japan., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan., Takahashi M; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Setoh K; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Matsuda K; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Nakano S; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan., Goto A; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Department of Health Data Science, Graduate School of Data Science, Yokohama City University, Yokohama, Japan., Katagiri R; Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan., Yamaji T; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan., Sawada N; Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan., Tsugane S; Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan., Wakai K; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan., Yamamoto M; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Sasaki M; Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Iwate, Japan.; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.; Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan., Iwasaki M; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan., Brennan P; Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France., Matsuo K; Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Publikováno v: Science advances [Sci Adv] 2024 Jan 26; Vol. 10 (4), pp. eade2780. Date of Electronic Publication: 2024 Jan 26.

107P Germline pathogenic variants identified in tissue- and blood-based whole exome sequencing in advanced solid tumors

Autor: Kuwata, T., Nakamura, Y., Fujisawa, T., Imai-Sumida, M., Kadowaki, S., Ueno, M., Boku, S., Nonomura, N., Oki, E., Radovich, M., Aitani, M., Tomozawa, C., Hiraoka, Y., Kimura, K., Kosugi, S., Imoto, I., Hirata, M., Yoshino, T.

Publikováno v: In Annals of Oncology September 2024 35 Supplement 2:S256-S257