Catalyzing the field of precision oncology, one basket at a time

Autor: Imola K Fodor, W. Pao

Publikováno v: Nature Medicine. 24:387-388

A bedside strategy to overcome the limitations of testing in preclinical models and to determine the role of gene mutations and their targetability directly in patients is presented.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d8f44e1f0c8e4a5e344c8f41181cc6
https://doi.org/10.1038/nm.4530

In situ validation of an intestinal stem cell signature in colorectal cancer

Autor: Gordon G A Hutchins, Hartmut Koeppen, Rajesh Patel, Murat Yaylaoglu, William F. Forrest, Imola K Fodor, Philip Quirke, Nianfeng Ge, Adrian M. Jubb, Debra Dunlap, J. K. Pine, Jennifer L. Ziskin

Publikováno v: Gut. 62:1012-1023

Objective Wnt/Tcf, Lgr5, Ascl2 and/or Bmi1 signalling is believed to define the mouse intestinal stem cell niche(s) from which adenomas arise. The aim of this study was to determine the relevance of these putative intestinal stem cell markers to huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfebcaca9159809d24e47ab91df784e
https://doi.org/10.1136/gutjnl-2011-301195

Cluster analysis of host cytokine responses to biodefense pathogens in a whole blood ex vivo exposure model (WEEM)

Autor: Sandra L. McCutchen-Maloney, Brett A. Chromy, Imola K Fodor, Paul A. Luciw, Nancy K Montgomery

Publikováno v: Chromy, Brett A; Fodor, Imola K; Montgomery, Nancy K; Luciw, Paul A; & McCutchen-Maloney, Sandra L. (2012). Cluster analysis of host cytokine responses to biodefense pathogens in a whole blood ex vivo exposure model (WEEM). BMC Microbiology, 12(1), 79. doi: http://dx.doi.org/10.1186/1471-2180-12-79. Retrieved from: http://www.escholarship.org/uc/item/0qk942m2
BMC Microbiology
BMC Microbiology, Vol 12, Iss 1, p 79 (2012)

Background Rapid detection and therapeutic intervention for infectious and emerging diseases is a major scientific goal in biodefense and public health. Toward this end, cytokine profiles in human blood were investigated using a human whole blood ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9389ee0f74778ae044262e904f904370
http://www.escholarship.org/uc/item/0qk942m2

Statistical challenges in the analysis of two-dimensional difference gel electrophoresis experiments using DeCyder

Autor: Michelle Alegria-Hartman, David O. Nelson, Todd H. Corzett, Kristin Robbins, Imola K. Fodor, Richard G. Langlois, Kenneth W. Turteltaub, Sandra L. McCutchen-Maloney

Publikováno v: Bioinformatics (Oxford, England). 21(19)

Motivation: The DeCyder software (GE Healthcare) is the current state-of-the-art commercial product for the analysis of two-dimensional difference gel electrophoresis (2D DIGE) experiments. Analyses complementing DeCyder are suggested by incorporatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9a031ed65d041200fb3d9a116d6363
https://pubmed.ncbi.nlm.nih.gov/16091413

Using independent component analysis to separate signals in climate data

Autor: Chandrika Kamath, Imola K. Fodor

Publikováno v: SPIE Proceedings.

Observed and simulated global temperature series include the effects of many different sources, such as volcano eruptions and El Nino Southern Oscillation (ENSO) variations. In order to compare the results of different models to each other, and to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::329ba2cffb37602566422a771bf44d3b
https://doi.org/10.1117/12.487277