Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Imola G. Zigoneanu"'
Publikováno v:
Analytical and Bioanalytical Chemistry. 407:8999-9008
Synthetic peptides incorporating well-folded β-hairpin peptides possess advantages in a variety of cell biology applications by virtue of increased resistance to proteolytic degradation. In this study, the WKpG β-hairpin peptide fused to a protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13106d8ffa690a90e638c501ee70051
https://doi.org/10.1007/s00216-015-9065-8
https://doi.org/10.1007/s00216-015-9065-8
Autor:
Nancy L. Allbritton, David S. Lawrence, Imola G. Zigoneanu, Qunzhao Wang, Christopher E. Sims, Angela Proctor
A peptidase-resistant ABL kinase substrate was developed by identifying protease-susceptible bonds on an ABL substrate peptide and replacing flanking amino acids with non-native amino acids. After an iterative design process, the lead, or designed, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120af827f1f29b78d1c6c301c184af20
https://europepmc.org/articles/PMC5111365/
https://europepmc.org/articles/PMC5111365/
Autor:
Imola G. Zigoneanu, Gary J. Pielak
Publikováno v:
Molecular Pharmaceutics. 9:1024-1029
We show that fluorine NMR can be used to monitor the insertion and change in conformation of a 19F-labeled cell-penetrating peptide upon interacting with the cellular plasma membrane. α-Synuclein and a construct comprising a cell-penetrating peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ef2a3454013e95e2ab51a9ea88e3fd
https://doi.org/10.1021/mp200615m
https://doi.org/10.1021/mp200615m
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1818:512-519
α-Synuclein, an intrinsically-disordered protein associated with Parkinson's disease, interacts with mitochondria, but the details of this interaction are unknown. We probed the interaction of α-synuclein and its A30P variant with lipid vesicles by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89de02c14a05e18e08802cebe54c0611
https://doi.org/10.1016/j.bbamem.2011.11.024
https://doi.org/10.1016/j.bbamem.2011.11.024
Autor:
Imola G, Zigoneanu, Gary J, Pielak
Publikováno v:
Molecular pharmaceutics. 9(4)
We show that fluorine NMR can be used to monitor the insertion and change in conformation of a 19F-labeled cell-penetrating peptide upon interacting with the cellular plasma membrane. α-Synuclein and a construct comprising a cell-penetrating peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4ee77fda7afad31c91e149329aa1445
https://pubmed.ncbi.nlm.nih.gov/22376087
https://pubmed.ncbi.nlm.nih.gov/22376087
Autor:
Alexander P. Schlesinger, Conggang Li, Kristin M. Slade, Imola G. Zigoneanu, Gui Fang Wang, Andrew C. Miklos, Gary J. Pielak
Almost everything we know about protein biophysics comes from studies on purified proteins in dilute solution. Most proteins, however, operate inside cells where the concentration of macromolecules can be >300 mg/mL. Although reductionism-based appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3068b0ddbd43943f6fc59d9572d4e4
Oxidative stress and aggregation of the protein alpha-synuclein are thought to be key factors in Parkinson's disease. Previous work shows that cytochrome c with H(2)O(2) causes tyrosine-dependent in vitro peroxidative aggregation of proteins, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69886d2c6ee09faef75f5d945821caaa
Autor:
Andrew C. Miklos, Kristin M. Slade, Conggang Li, Imola G. Zigoneanu, Gary J. Pielak, Gui Fang Wang, Alexander P. Schlesinger
Publikováno v:
Biochemistry. 48:9170-9170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3966fba259e552a5daadcceef473cbc9
https://doi.org/10.1021/bi9014715
https://doi.org/10.1021/bi9014715
Publikováno v:
Biophysical Journal. (3):552a
Oxidative stress and aggregation of the protein μ-synuclein are thought to be key factors in Parkinson's disease. Previous work shows that cytochrome c plus H2O2 causes tyrosine-dependant in vitro peroxidative aggregation of proteins, including μ-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3c3c4a008d8ae2386209ec062f03cd