Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3.

Autor: Hu, Yun¹ (AUTHOR), Paris, Sébastien² (AUTHOR), Sahoo, Narayan³ (AUTHOR), Wang, Qi⁴ (AUTHOR), Wang, Qianxia^3,5 (AUTHOR), Barsoumian, Hampartsoum B.¹ (AUTHOR), Huang, Ailing¹ (AUTHOR), Da Silva, Jordan² (AUTHOR), Bienassis, Célia² (AUTHOR), Leyton, Claudia S. Kettlun¹ (AUTHOR), Voss, Tiffany A.¹ (AUTHOR), Masrorpour, Fatemeh¹ (AUTHOR), Riad, Thomas¹ (AUTHOR), Leuschner, Carola¹ (AUTHOR), Puebla-Osorio, Nahum¹ (AUTHOR), Gandhi, Saumil¹ (AUTHOR), Nguyen, Quynh-Nhu¹ (AUTHOR), Wang, Jing⁴ (AUTHOR), Cortez, Maria Angelica¹ (AUTHOR), Welsh, James W.¹ (AUTHOR) Jwelsh@mdanderson.org

Publikováno v: Journal of Nanobiotechnology. 10/1/2024, Vol. 22 Issue 1, p1-22. 22p.

Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Autor: Yun Hu, Alexey Revenko, Hampartsoum Barsoumian, Genevieve Bertolet, Natalie Wall Fowlkes, Hadi Maazi, Morgan Maureen Green, Kewen He, Duygu Sezen, Tiffany A. Voss, Claudia S Kettlun Leyton, Fatemeh Masrorpour, Zahid Rafiq, Nahum Puebla-Osorio, Carola Leuschner, Robert MacLeod, Maria Angelica Cortez, James W. Welsh

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)

Abstract Background The combination of radiotherapy and immunotherapy (immunoradiotherapy) has been increasingly used for treating a wide range of cancers. However, some tumors are resistant to immunoradiotherapy. We have previously shown that MER pr

Externí odkaz: https://doaj.org/article/bfe32f32799d4d64804e7e64eb090fe4

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Combining a nanoparticle-mediated immunoradiotherapy with dual blockade of LAG3 and TIGIT improves the treatment efficacy in anti-PD1 resistant lung cancer

Autor: Yun Hu, Sébastien Paris, Genevieve Bertolet, Hampartsoum B. Barsoumian, Kewen He, Duygu Sezen, Dawei Chen, Mark Wasley, Jordan DA SILVA, Joylise A. Mitchell, Tiffany A. Voss, Fatemeh Masrorpour, Claudia Kettlun Leyton, Liangpeng Yang, Carola Leuschner, Nahum Puebla-Osorio, Saumil Gandhi, Quynh-Nhu Nguyen, Maria Angelica Cortez, James W. Welsh

Publikováno v: Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-19 (2022)

Abstract Background While improvements in immunoradiotherapy have significantly improved outcomes for cancer patients, this treatment approach has nevertheless proven ineffective at controlling the majority of malignancies. One of the mechanisms of r

Externí odkaz: https://doaj.org/article/a090d791bef0465c93bf5eb25e2451f7

NBTXR3 improves the efficacy of immunoradiotherapy combining nonfucosylated anti-CTLA4 in an anti-PD1 resistant lung cancer model

Autor: Yun Hu, Sébastien Paris, Genevieve Bertolet, Hampartsoum B. Barsoumian, Qi Wang, Jordan Da Silva, Nalini B. Patel, Nguyen Nguyen, Denaha J. Doss, Ailing Huang, Ethan Hsu, Claudia S. Kettlun Leyton, Tiffany A. Voss, Fatemeh Masrorpour, Carola Leuschner, Jordan T. Pietz, Nahum Puebla-Osorio, Saumil Gandhi, Quynh-Nhu Nguyen, Jing Wang, Maria Angelica Cortez, James W. Welsh

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The efficacy of immunoradiotherapy consisting of radiation therapy and immune checkpoint blockade relies on effectively promoting the systemic antitumor immune response’s activation while simultaneously reducing local factors favoring immune suppre

Externí odkaz: https://doaj.org/article/b52124ce446c4e9989debf373cb9acaf