Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts

Autor: H. Ying, Ann McCormack, Marlene L. Rose, Federica M. Marelli-Berg, Padmini Sarathchandra, H. Fu, K. Okkenhaug

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 3, p e32892 (2012)

Chronic rejection is the major cause of long-term heart allograft failure, characterized by tissue infiltration by recipient T cells with indirect allospecificity. Phosphoinositol-3-kinase p110δ is a key mediator of T cell receptor signaling, regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de8691c57d459ccbe5f74900c860c8c

The immunomodulatory role of syncytiotrophoblast microvesicles

Autor: Dionne Tannetta, Ian L. Sargent, J Southcombe, Christopher W.G. Redman

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 5, p e20245 (2011)

Immune adaptation is a critical component of successful pregnancy. Of primary importance is the modification of cytokine production upon immune activation. With the discovery that normal pregnancy itself is a pro-inflammatory state, it was recognised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544d77d64705954037c04c86417aae07
https://ora.ox.ac.uk/objects/uuid:a4664512-16e3-4360-9c9a-b7ffe10d428f

Retraction: Innate Immune Activation by Inhaled Lipopolysaccharide, Independent of Oxidative Stress, Exacerbates Silica-Induced Pulmonary Fibrosis in Mice

Autor: David M. Brass, Jennifer C. Spencer, Zhuowei Li, Erin Potts-Kant, Sarah M. Reilly, Mary K. Dunkel, Joseph D. Latoche, Richard L. Auten, John W. Hollingsworth, Cheryl L. Fattman

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155388 (2016)
PLoS ONE

Acute exacerbations of pulmonary fibrosis are characterized by rapid decrements in lung function. Environmental factors that may contribute to acute exacerbations remain poorly understood. We have previously demonstrated that exposure to inhaled lipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c84d47c7c33c79ee1b814ae88bab460
http://europepmc.org/articles/PMC4861287?pdf=render

Vitamin D Status and Chronic Obstructive Pulmonary Disease: A Prospective General Population Study

Autor: Tea Skaaby, Charlotta Pisinger, Betina H. Thuesen, Runa Vavia Fenger, Torben Jørgensen, Lise Lotte N. Husemoen, Allan Linneberg

Publikováno v: PLoS ONE
Skaaby, T, Husemoen, L L N, Thuesen, B H, Pisinger, C, Jørgensen, T, Fenger, R V & Linneberg, A 2014, ' Vitamin D status and chronic obstructive pulmonary disease : A prospective general population study ', PLoS ONE, vol. 9, no. 3, e90654 . https://doi.org/10.1371/journal.pone.0090654
PLoS ONE, Vol 9, Iss 3, p e90654 (2014)

ObjectivesVitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD). Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity. We investigated the associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33da5206dc5675726f2ae13f73ff0da7
http://europepmc.org/articles/PMC3942472

Modulation of Innate Immune Responses by Influenza-Specific Ovine Polyclonal Antibodies Used for Prophylaxis

Autor: Cassandra M. Berry, W.J. Penhale, Philip A. Stumbles, Guan K. Tay, Catherine Rinaldi

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e89674 (2014)

In the event of a novel influenza A virus pandemic, prophylaxis mediated by antibodies provides an adjunct control option to vaccines and antivirals. This strategy is particularly pertinent to unvaccinated populations at risk during the lag time to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e89d009865c5db803af6d8b42be5b16
http://europepmc.org/articles/PMC3938480