Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Immunologic Receptor Signaling"'
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e51243 (2013)
PLoS ONE
PLoS ONE
Toll-like Receptors (TLR) are phylogenetically conserved transmembrane proteins responsible for detection of pathogens and activation of immune responses in diverse animal species. The stimulation of TLR by pathogen-derived molecules leads to the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08c89d83d04a6028ee864b1d2933787
https://doi.org/10.1371/journal.pone.0051243
https://doi.org/10.1371/journal.pone.0051243
Autor:
Erlene K. Seymour, Andrew D. Zelenetz, Kelly Piersanti, Carly G. K. Ziegler, Sami N. Malek, Jeffrey Gardner, Kurt S. Bantilan, Robert S. Balderas, M. Lia Palomba, Hugo Decker, Ivelise Rijo, Debra L Bemis, Jesse W. Cotari, Grégoire Altan-Bonnet, Mark L. Heaney, Marcel R.M. van den Brink
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e79987 (2014)
PLoS ONE
PLoS ONE
Purpose Chronic Lymphocytic Leukemia (CLL) is defined by a perturbed B-cell receptor-mediated signaling machinery. We aimed to model differential signaling behavior between B cells from CLL and healthy individuals to pinpoint modes of dysregulation.
Autor:
Siva Kumar Kolluri, Hyo Sang Jang, Jamie M. Pennington, Sumit Punj, Patrick L. Iversen, Diana Rohlman, Jessica Lynne Phillips, Prasad Rao Kopparapu, Edmond F. O’Donnell, Nancy I. Kerkvliet
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88726 (2014)
PLoS ONE
PLoS ONE
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays multiple roles in regulation of immune and inflammatory responses. The ability of certain AhR ligands to induce regulatory T cells (Tregs) has generated interes
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85619 (2014)
PLoS ONE
PLoS ONE
Head and Neck Squamous Cell Carcinoma (HNSCC) encompasses malignancies that arise in the mucosa of the upper aerodigestive tract. Recent high throughput DNA sequencing revealed HNSCC genes mutations that contribute to several cancer cell characterist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62f6b8cb69cdfae8484e1234b12f9af
http://hdl.handle.net/10722/214443
http://hdl.handle.net/10722/214443
Autor:
Virginia Smith Shapiro, Joanna Kim, Michael J. Shapiro, Daniel D. Billadeau, Adebowale O. Bamidele, Puspa Thapa, Henry N. Higgs, Pinar S. Gurel, Karen E. Hedin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85090 (2014)
PLoS ONE
PLoS ONE
Actin depolymerizing factor-homology (ADF-H) family proteins regulate actin filament dynamics at multiple cellular locations. Herein, we have investigated the function of the ADF-H family member coactosin-like 1 (COTL1) in the regulation of actin dyn
Autor:
Taro Watabe, Michio Onizawa, Masahiro Suzuki, Yuriko Sakamaki, Ryuichi Okamoto, Hideo Yagita, Tetsuya Nakamura, Shigeru Oshima, Shizuko Ichinose, Motoyuki Shimonaka, Mamoru Watanabe, Motomi Yamazaki, Takashi Nagaishi, Mamoru Totsuka
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88369 (2014)
PLoS ONE
PLoS ONE
It has been suggested that prolonged inflammatory bowel diseases (IBD) may lead to colitis-associated carcinogenesis (CAC). We previously observed that the NF-κB activation in colonic epithelial cells is associated with increased tumor necrosis fact
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87859 (2014)
PLoS ONE
PLoS ONE
Polymorphonuclear leukocytes (PMNs) are essential for the human innate immune defense, limiting expansion of invading microorganisms. PMN turnover is controlled by apoptosis, but the regulating signaling pathways remain elusive, largely due to inhere
Autor:
Katsuhiro Io, Masanobu Shinohara, Masayuki Kobayashi, Keisuke Shindo, Yasuyuki Arai, Fumie Iwai, Yoko Takiuchi, Yoshio Koyanagi, Akifumi Takaori-Kondo, Norimitsu Kadowaki, Kayoko Nagata, Kouhei Yamashita, Takashi Sakamoto, Kohei Tada
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85762 (2014)
PLoS ONE
PLoS ONE
The transcription factor NF-κB plays a key regulatory role in lymphocyte activation and generation of immune response. Stimulation of T cell receptor (TCR) induces phosphorylation of CARMA1 by PKCθ, resulting in formation of CARMA1-Bcl10-MALT1 (CBM
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85875 (2014)
PLoS ONE
PLoS ONE
Jawless vertebrates represented by lampreys and hagfish use variable lymphocyte receptors (VLRs) as antigen receptors to mount adaptive immune responses. VLRs generate diversity that is comparable to immunoglobulins and T-cell receptors by a gene con
Autor:
Richard G. Bauserman, Margaret M. Fettis, James H. Miller, Richard E. Waugh, Trissha R. Higa, Ana Rojas, Mariano Sanchez-Lockhart, Hongyu Miao
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e89263 (2014)
PLoS ONE, Vol 9, Iss 2, p e89263 (2014)
T cell activation takes place in the context of a spatial and kinetic reorganization of cell surface proteins and signaling molecules at the contact site with an antigen presenting cell, termed the immunological synapse. Coordination of the activatio