Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

Autor: Garofalo, Maura, Piccoli, Luca, Romeo, Margherita, Barzago, Maria M., Ravasio, Sara, Foglierini, Mathilde, Matkovic, Milos, Sgrignani, Jacopo, De Gasparo, Raoul, Prunotto, Marco, Varani, Luca, Diomede, Luisa, Michielin, Olivier, Lanzavecchia, Antonio, Cavalli, Andrea

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature communications, vol. 12, no. 1, pp. 3532
Nature Communications, 12

In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains (LC) form toxic aggregates and amyloid fibrils in target organs. Prompt diagnosis is crucial to avoid permanent organ damage, but delayed diagnosis is common

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ed30ebb7fdc446e67577f44a7588df

A transgenic mouse model of autoimmune glomerulonephritis and necrotizing arteritis associated with cryoglobulinemia

Autor: Satoru Takahashi, Shozo Izui, Liliane Fossati-Jimack, Robert Lemoine, Thierry Fulpius, Haruyoshi Yoshida, Aki Kuroki, Shuichi Kikuchi, Luc Reininger, Kimi Araki, Yves D. Pastore

Publikováno v: Journal of Immunology, Vol. 169, No 8 (2002) pp. 4644-4650

Mice implanted with hybridoma secreting 6-19 IgG3 anti-IgG2a rheumatoid factor (RF) with cryoglobulin activity develop acute glomerulonephritis and cutaneous leukocytoclastic vasculitis. As the RF activity is implicated in the skin, but not glomerula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06aded1f35277a759e82f3e010f07b4d
https://archive-ouverte.unige.ch/unige:11374