Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Immunoglobulin Heavy Chains/genetics"'
Autor:
Du, Wenjuan, Janssens, Rick, Mykytyn, Anna Z, Li, Wentao, Drabek, Dubravka, van Haperen, Rien, Chatziandreou, Marianthi, Rissmann, Melanie, van der Lee, Joline, van Dortmondt, Melissa, Martin, Itziar Serna, van Kuppeveld, Frank J M, Hurdiss, Daniel L, Haagmans, Bart L, Grosveld, Frank, Bosch, Berend-Jan, Virologie
Publikováno v:
Frontiers in Immunology, 14:1111385. Frontiers Media S.A.
Frontiers in Immunology, 14. Frontiers Media S.A.
Frontiers in Immunology, 14. Frontiers Media S.A.
Emerging SARS-CoV-2 variants have accrued mutations within the spike protein rendering most therapeutic monoclonal antibodies against COVID-19 ineffective. Hence there is an unmet need for broad-spectrum mAb treatments for COVID-19 that are more resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8fb0d6edcdd23a06ea613e489d520c
https://pure.eur.nl/en/publications/3a43e91f-48f8-4f33-8efb-15b914992b63
https://pure.eur.nl/en/publications/3a43e91f-48f8-4f33-8efb-15b914992b63
Autor:
Tina E Kjeldsen, Astrid Thomsen, Christine Søholm Hansen, Dianna Hussmann, Lise Lotte Hansen, Karina Dalsgaard Johansen, Thomas Kielsgaard Kristensen, Jonas Bybjerg-Grauholm, Louise Kristensen, Iben Daugaard, Thomas Stauffer Larsen, Tomasz K. Wojdacz, Anna Starnawska, Maja Ludvigsen, Michael Boe Møller, Charlotte Guldborg Nyvold
Publikováno v:
Hussmann, D, Starnawska, A, Kristensen, L, Daugaard, I, Thomsen, A, Kjeldsen, T, Hansen, C S, Bybjerg-Grauholm, J, Dalsgaard Johansen, K, Ludvigsen, M, Kristensen, T, Larsen, T S, Møller, M B, Nyvold, C G, Hansen, L L & Wojdacz, T K 2022, ' IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load ', Haematologica, vol. 107, no. 4, pp. 877-886 . https://doi.org/10.3324/haematol.2021.278477
Hussmann, D, Starnawska, A, Kristensen, L, Daugaard, I, Thomsen, A, Kjeldsen, T E, Hansen, C S, Bybjerg-Grauholm, J, Johansen, K D, Ludvigsen, M, Kristensen, T, Larsen, T S, Møller, M B, Nyvold, C G, Hansen, L L & Wojdacz, T K 2022, ' IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load ', Haematologica, vol. 107, no. 4, pp. 877-886 . https://doi.org/10.3324/haematol.2021.278477
Hussmann, D, Starnawska, A, Kristensen, L, Daugaard, I, Thomsen, A, Kjeldsen, T E, Hansen, C S, Bybjerg-Grauholm, J, Johansen, K D, Ludvigsen, M, Kristensen, T, Larsen, T S, Møller, M B, Nyvold, C G, Hansen, L L & Wojdacz, T K 2022, ' IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load ', Haematologica, vol. 107, no. 4, pp. 877-886 . https://doi.org/10.3324/haematol.2021.278477
Currently, no molecular biomarker indices are used in standard care to make treatment decisions at diagnosis of chronic lymphocytic leukemia (CLL). We used Infinium MethylationEPIC array data from diagnostic blood samples of 114 CLL patients and deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8015b7eb2deef9a766702d6fe297e3
https://pure.au.dk/portal/da/publications/ighvassociated-methylation-signatures-more-accurately-predict-clinical-outcomes-of-chronic-lymphocytic-leukemia-patients-than-ighv-mutation-load(fb8eb304-9b04-4160-b930-6f27f47e59cc).html
https://pure.au.dk/portal/da/publications/ighvassociated-methylation-signatures-more-accurately-predict-clinical-outcomes-of-chronic-lymphocytic-leukemia-patients-than-ighv-mutation-load(fb8eb304-9b04-4160-b930-6f27f47e59cc).html
Autor:
Stuart Blakemore, Tomasz K. Wojdacz, Christoph Plass, Basile Stamatopoulos, Monica Else, Helen Parker, Daniel Catovsky, Andrew Collins, Peter Hillmen, Dena R. Howard, Latha Kadalayil, Marta Larrayoz, Jade Forster, Anna Schuh, Andrew J. Steele, Jonathan C. Strefford, Pauline Robbe, Harindra E. Amarasinghe, Alice Beattie, Christopher C. Oakes, Dean Bryant, Zadie Davis, Matthew J. J. Rose-Zerilli, David Oscier, Richard Rosenquist, Andrew R. Pettitt, Ruth Clifford
Publikováno v:
Blood Advances, 3 (16
Wojdacz, T K, Amarasinghe, H E, Kadalayil, L, Beattie, A, Forster, J, Blakemore, S J, Parker, H, Bryant, D, Larrayoz, M, Clifford, R, Robbe, P, Davis, Z A, Else, M, Howard, D R, Stamatopoulos, B, Steele, A J, Rosenquist, R, Collins, A, Pettitt, A R, Hillmen, P, Plass, C, Schuh, A, Catovsky, D, Oscier, D G, Rose-Zerilli, M J J, Oakes, C C & Strefford, J C 2019, ' Clinical significance of DNA methylation in chronic lymphocytic leukemia patients : Results from 3 UK clinical trials ', Blood Advances, vol. 3, no. 16, pp. 2474-2481 . https://doi.org/10.1182/bloodadvances.2019000237
Wojdacz, T K, Amarasinghe, H E, Kadalayil, L, Beattie, A, Forster, J, Blakemore, S J, Parker, H, Bryant, D, Larrayoz, M, Clifford, R, Robbe, P, Davis, Z A, Else, M, Howard, D R, Stamatopoulos, B, Steele, A J, Rosenquist, R, Collins, A, Pettitt, A R, Hillmen, P, Plass, C, Schuh, A, Catovsky, D, Oscier, D G, Rose-Zerilli, M J J, Oakes, C C & Strefford, J C 2019, ' Clinical significance of DNA methylation in chronic lymphocytic leukemia patients : Results from 3 UK clinical trials ', Blood Advances, vol. 3, no. 16, pp. 2474-2481 . https://doi.org/10.1182/bloodadvances.2019000237
Chronic lymphocytic leukemia patients with mutated immunoglobulin heavy-chain genes (IGHV-M), particularly those lacking poor-risk genomic lesions, often respond well to chemoimmunotherapy (CIT). DNA methylation profiling can subdivide early-stage pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a700ce4efb47801177a0ee7c05b1b7c2
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/296789
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/296789
LPL gene expression is associated with poor prognosis in CLL and closely related to NOTCH1 mutations
Autor:
Louise Kristensen, Thomas Kielsgaard Kristensen, Niels Abildgaard, Michael Boe Møller, Elias Campo, Torben Mourits-Andersen, Mikael Frederiksen, Cristina Royo
Publikováno v:
Kristensen, L, Kielsgaard Kristensen, T, Abildgaard, N, Royo, C, Frederiksen, M, Mourits-Andersen, H T, Campo, E & Møller, M B 2016, ' LPL gene expression is associated with poor prognosis in CLL and closely related to NOTCH1 mutations ', European Journal of Haematology, vol. 97, no. 2, pp. 175-182 . https://doi.org/10.1111/ejh.12700
Introduction Chronic lymphocytic leukemia is a heterogeneous yet incurable disease. Whole-genome and whole-exome sequencing studies have revealed recurrently occurring somatic mutations in some genes. Several other prognostic markers have previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cc9177b73de86fc79a9b0de3920097
https://portal.findresearcher.sdu.dk/da/publications/90ad0851-4f95-4c35-b6ba-46fa4b37cba9
https://portal.findresearcher.sdu.dk/da/publications/90ad0851-4f95-4c35-b6ba-46fa4b37cba9
Autor:
Roger Weil, Andreas Hirt, Martin F. Fey, Edward W. Khandjian, Andreas Tobler, Barbara Stadelmann, Delaleu B, Annette Ridolfi-Lüthy, Wagner Hp, Lore Theilkäs
Publikováno v:
European Journal of Haematology, Vol. 45, No 4 (1990) pp. 215-222
13 cases of childhood acute lymphoblastic leukaemia (ALL) were studied combining cell surface marker analysis with immunogenotyping by Southern blot hybridisation with a panel of antigen receptor gene probes. The immunophenotypes were unequivocal: 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2717242a7b126c8f0119eb35c81d03c7
https://doi.org/10.1111/j.1600-0609.1990.tb00460.x
https://doi.org/10.1111/j.1600-0609.1990.tb00460.x
Autor:
Anne Stidsholt Roug, Charlotte Guldborg Nyvold, Peter Hokland, Eigil Kjeldsen, Palle Villesen, Line Nederby, Marcus Celik Hansen
Publikováno v:
Hansen, M C, Nyvold, C G, Roug, A S, Kjeldsen, E, Villesen, P, Nederby, L & Hokland, P 2015, ' Nature and nurture: a case of transcending haematological pre-malignancies in a pair of monozygotic twins adding possible clues on the pathogenesis of B-cell proliferations ', British Journal of Haematology, vol. 169, no. 3, pp. 391–400 . https://doi.org/10.1111/bjh.13305
We describe a comprehensive molecular analysis of a pair of monozygotic twins, who came to our attention when one experienced amaurosis fugax and was diagnosed with JAK2+ polycythaemia vera. He (Twin A) was also found to have an asymptomatic B-cell c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af3ec30e74bb4b0a115b0987b94f207
https://portal.findresearcher.sdu.dk/da/publications/39bb619b-26e2-478c-911f-f250a3bac125
https://portal.findresearcher.sdu.dk/da/publications/39bb619b-26e2-478c-911f-f250a3bac125
Autor:
Dirk Hose, Surinder S. Sahota, Dean Bryant, Nicola J. Weston-Bell, Anja Seckinger, Graeme J. M. Cowan, Niklas Zojer
Publikováno v:
Cowan, G, Weston-Bell, N J, Bryant, D, Seckinger, A, Hose, D, Zojer, N & Sahota, S S 2015, ' Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma ', Oncotarget, vol. 6, no. 15, pp. 13229-40 . https://doi.org/10.18632/oncotarget.3644
Oncotarget
Oncotarget
Human multiple myeloma (MM) is characterized by accumulation of malignant terminally differentiated plasma cells (PCs) in the bone marrow (BM), raising the question when during maturation neoplastic transformation begins. Immunoglobulin IGHV genes ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836a093844e866208581b8255d638235
https://www.pure.ed.ac.uk/ws/files/118261760/3644_55655_2_PB.pdf
https://www.pure.ed.ac.uk/ws/files/118261760/3644_55655_2_PB.pdf
Autor:
Etienne Coyaud, Norbert Ifrah, Nicole Dastugue, M C Béné, Kheira Beldjord, André Delannoy, Eric Delabesse, J M Cayuela, Pierre Brousset, Cyril Broccardo, J Soulier, Claude Preudhomme, Marina Bousquet, Hélène Cavé, Julien Familiades, Marina Lafage-Pochitaloff, Odile Blanchet, F. Huguet, Hervé Dombret, Yves Chalandon, Sophie Dobbelstein, Cathy Quelen, V Lhéritier, E Macintyre, Stéphanie Struski, Nais Prade-Houdellier, Nathalie Grardel, J. De Vos, Arnaud Pigneux
Publikováno v:
Leukemia, Vol. 23, No 11 (2009) pp. 1989-98
Adult and child B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) differ in terms of incidence and prognosis. These disparities are mainly due to the molecular abnormalities associated with these two clinical entities. A genome-wide analysis u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e922cd4c776eab4a37a102585bf82f7
https://archive-ouverte.unige.ch/unige:25875
https://archive-ouverte.unige.ch/unige:25875
Autor:
Benjamin Haibe-Kains, Nathalie Meuleman, Martine Massy, Hughes Duvillier, Philippe Martiat, Basile Stamatopoulos, Dominique Bron, Laurence Lagneaux
Publikováno v:
Clinical chemistry, 53 (10
BACKGROUND: Chronic lymphocytic leukemia (CLL) is heterogeneous with respect to prognosis and clinical outcome. The mutational status of the immunoglobulin variable heavy chain region (IGHV) has been used to classify patients into 2 groups in terms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c431acdde2fa9656d264b3e9ca7a06
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50415
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50415
Autor:
Thierry Fulpius, Aki Kuroki, Liliane Fossati-Jimack, Munehiro Nakata, Frédéric Lajaunias, Shozo Izui, Yasuhiro Kuroda, Toho Toda, Naoya Kojima, Shuichi Kikuchi, Yves D. Pastore, Tsuguo Mizuochi, Luc Reininger
Publikováno v:
Blood, Vol. 99, No 8 (2002) pp. 2922-2928
Autoantibodies of the cryoprecipitating IgG3 isotype have been shown to play a significant role in the development of murine lupus–like autoimmune syndrome. At present, the structural basis of IgG3 cryoprecipitation and its role in autoantibody pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489a928b83075a1512a54a501d03066e
https://pubmed.ncbi.nlm.nih.gov/11929783
https://pubmed.ncbi.nlm.nih.gov/11929783