Three-dimensional architecture of the IgH locus facilitates class switch recombination.

Autor: Kenter, Amy L.¹ (AUTHOR), Feldman, Scott¹ (AUTHOR), Wuerffel, Robert¹ (AUTHOR), Achour, Ikbel¹ (AUTHOR), Wang, Lili¹ (AUTHOR), Kumar, Satyendra¹ (AUTHOR)

Publikováno v: Annals of the New York Academy of Sciences. Sep2012, Vol. 1267 Issue 1, p86-94. 9p. 4 Diagrams.

Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo

Autor: Daan Augustijn, Karli R. Reiding, C. Erik Hack, Louis J. Bont, Maaike Nederend, Jeanette H. W. Leusen, Manfred Wuhrer, Frank E. J. Coenjaerts, Shamir R. Jacobino, Jan Meeldijk, J. H. Marco Jansen, J. Frederiek Reijneveld

Publikováno v: mAbs, 10(3), 453. Landes Bioscience
mAbs
mAbs, 10(3), 453-462

Respiratory syncytial virus (RSV) infection is a leading cause of hospitalization and mortality in young children. Protective therapy options are limited. Currently, palivizumab, a monoclonal IgG1 antibody, is the only licensed drug for RSV prophylax

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3cd91f31232627ce6680f38ab00673
https://doi.org/10.1080/19420862.2018.1433974

The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors

Autor: Ole Birger Pedersen, Leif Kofoed Nielsen, Lise Wegner Thørner, Morten Hanefeld Dziegiel, Christian Erikstrup, Charlotte Kaestel Jensen, Erik Sørensen, Kaspar René Nielsen, Kathrine Agergård Kaspersen, Maria Didriksen, Sabina Chaudhary Hauge, Henrik Ullum, Henrik Hjalgrim

Publikováno v: Hauge, S C, Jensen, C K, Nielsen, L K, Pedersen, O B, Sørensen, E, Thørner, L W, Hjalgrim, H, Erikstrup, C, Nielsen, K R, Kaspersen, K A, Didriksen, M, Dziegiel, M & Ullum, H 2018, ' The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors ', APMIS Supplementum, vol. 126, no. 3, pp. 248-256 . https://doi.org/10.1111/apm.12807
Hauge, S C, Jensen, C K, Nielsen, L K, Pedersen, O B, Sørensen, E, Thørner, L W, Hjalgrim, H, Erikstrup, C, Nielsen, K R, Kaspersen, K A, Didriksen, M, Dziegiel, M & Ullum, H 2018, ' The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors ', A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, vol. 126, no. 3, pp. 248-256 . https://doi.org/10.1111/apm.12807
Hauge, S C, Jensen, C K, Nielsen, L K, Pedersen, O B, Sørensen, E, Thørner, L W, Hjalgrim, H, Erikstrup, C, Nielsen, K R, Kaspersen, K A, Didriksen, M, Dziegiel, M & Ullum, H 2018, ' The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors ', APMIS-Journal of Pathology, Microbiology and Immunology, vol. 126, no. 3, pp. 248-256 . https://doi.org/10.1111/apm.12807

The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self-reported mental and physical health and the risk of infection in IgA-deficient blood donors compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c5fc3da70c014514bb8ecdbc6a8a6a
https://pure.au.dk/portal/da/publications/the-association-of-iga-deficiency-on-infection-rate-selfperceived-health-and-levels-of-creactive-protein-in-healthy-blood-donors(f139be39-637d-470e-bc28-3a739e7d1232).html

Type i CD20 antibodies recruit the B cell receptor for complement-dependent lysis of malignant B cells

Autor: Paul W. H. I. Parren, Marleen Voorhorst, Patrick J. Engelberts, Tom Vink, Frank J. Beurskens, Thomas Valerius, Wendy J.M. Mackus, Joost M. Bakker, Stefanie Derer, Tom van Meerten, Esther C.W. Breij, Janine Schuurman, Jan G. J. van de Winkel

Publikováno v: Engelberts, P J, Voorhorst, M, Schuurman, J, Van Meerten, T, Bakker, J M, Vink, T, Mackus, W J M, Breij, E C W, Derer, S, Valerius, T, van de Winkel, J G J, Parren, P W H I & Beurskens, F J 2016, ' Type i CD20 antibodies recruit the B cell receptor for complement-dependent lysis of malignant B cells ', Journal of Immunology, vol. 197, no. 12, pp. 4829-4837 . https://doi.org/10.4049/jimmunol.1600811
Journal of Immunology, 197(12), 4829-4837. AMER ASSOC IMMUNOLOGISTS

Human IgG1 type I CD20 Abs, such as rituximab and ofatumumab (OFA), efficiently induce complement-dependent cytotoxicity (CDC) of CD20+ B cells by binding of C1 to hexamerized Fc domains. Unexpectedly, we found that type I CD20 Ab F(ab')2 fragments,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d9197ec28f899d5e6a016465f31efa
https://portal.findresearcher.sdu.dk/da/publications/34aca668-9af2-49ed-945c-3a69d108b381

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

Autor: de Jong, Rob N, Beurskens, Frank J, Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D, Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J, Oostindie, Simone C, Wang, Guanbo, Heck, Albert J R, Schuurman, Janine, Parren, Paul W H I, Sub Biomol.Mass Spectrometry & Proteom., Sub Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: PloS Biology [E], 14(1). Public Library of Science
PLoS Biology, Vol 14, Iss 1, p e1002344 (2016)
PLoS Biology
de Jong, R N, Beurskens, F J, Verploegen, S, Strumane, K, van Kampen, M D, Voorhorst, M, Horstman, W, Engelberts, P J, Oostindie, S C, Wang, H-G, Heck, A J R, Schuurman, J & Parren, P W H I 2016, ' A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface ', PLoS Biology, vol. 14, no. 1, e1002344, pp. e1002344 . https://doi.org/10.1371/journal.pbio.1002344

IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing. Here, we translated this natural concept into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20b4bdc5f5cb3b10d2b50e70c8b89da
https://dspace.library.uu.nl/handle/1874/325541