Zobrazeno 1 - 10
of 530
pro vyhledávání: '"Immunodeficient Mouse"'
Autor:
Hiroaki Taketsuru, Runa Hirayama, Ena Nakatsukasa, Rie Natsume, Keizo Takao, Manabu Abe, Kenji Sakimura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The idea of utilizing unused oocytes present in the ovaries has been tested in various ways to produce offspring. However, only a limited number of studies succeeded in offspring generation. They include transplantation of ovaries into autol
Externí odkaz:
https://doaj.org/article/dd85504c415842a7b11e644a610b5501
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104601- (2023)
Summary: Peritoneal metastasis is a challenging aspect of clinical practice for gastric cancer. Animal models are crucial in understanding molecular mechanisms, assessing drug efficacy, and conducting clinical intervention studies, including those re
Externí odkaz:
https://doaj.org/article/9b9d6f7fa83f4f0bbea3f4e707adeb2e
Akademický článek
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Autor:
Jiaxuan Chen, Shuzhen Liao, Zengzhi Xiao, Quanren Pan, Xi Wang, Kangyuan Shen, Shuting Wang, Lawei Yang, Fengbiao Guo, Hua-feng Liu, Qingjun Pan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Animal models play an indispensable role in the study of human diseases. However, animal models of different diseases do not fully mimic the complex internal environment of humans. Immunodeficient mice are deficient in certain genes and do not expres
Externí odkaz:
https://doaj.org/article/f1df49a3f6a54785b6b7c70dc3311533
Autor:
Shinsuke Nakajima, Kazu Okuma
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11737 (2023)
Adult T cell leukemia (ATL) is an aggressive hematologic disease caused by human T cell leukemia virus type 1 (HTLV-1) infection. Various animal models of HTLV-1 infection/ATL have been established to elucidate the pathogenesis of ATL and develop app
Externí odkaz:
https://doaj.org/article/d00e260f7c604349b1897eb56ec5fd97
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal bone-marrow diseases with ineffective hematopoiesis resulting in cytopenias and morphologic dysplasia of hematopoietic cells. MDS carry a wide spectrum of genetic abnormalities, rang
Externí odkaz:
https://doaj.org/article/fb326ed236504478b4cc24d7e74cfc51
Autor:
Inseon Bak, Doo-Jin Kim, Hyoung-Chin Kim, Hye-Jun Shin, Eunhye Yu, Kyeong-Won Yoo, Dae-Yeul Yu
Publikováno v:
Laboratory Animal Research, Vol 36, Iss 1, Pp 1-11 (2020)
Abstract Genome editing has recently emerged as a powerful tool for generating mutant mice. Small deletions of nucleotides in the target genes are frequently found in CRISPR/Cas9 mediated mutant mice. However, there are very few reports analyzing the
Externí odkaz:
https://doaj.org/article/68674f6206884ab3ac1696a4de81d683
Autor:
Jiaxuan Chen, Shuzhen Liao, Huimin Zhou, Lawei Yang, Fengbiao Guo, Shuxian Chen, Aifen Li, Quanren Pan, Chen Yang, Hua-feng Liu, Qingjun Pan
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Animal models have played a crucial role in the understanding of the mechanisms and treatments of human diseases; however, owing to the large differences in genetic background and disease-specific characteristics, animal models cannot fully simulate
Externí odkaz:
https://doaj.org/article/92149c1124514cbea3338bb3fbaedc9b
Autor:
Boas, Fernanda Lima Vilas
O transplante de células-tronco hematopoéticas (CTHs) é o tipo de terapia celular mais usada atualmente. As células-tronco da medula óssea humana, do sangue periférico mobilizado e do sangue do cordão umbilical (SCU) são as únicas fontes de
Autor:
Vrusha K. Shah, Bonnie Hall, E. Antonio Chiocca, Joseph C. Glorioso, Justus B. Cohen, Joseph W. Jackson, Marco Marzulli, William F. Goins, Lisa Bailey, Gary Kohanbash
Publikováno v:
Molecular Therapy: Oncolytics, Vol 22, Iss, Pp 444-453 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Oncolytic herpes simplex viruses (oHSVs) have demonstrated efficient lytic replication in human glioblastoma tumors using immunodeficient mouse models, but early-phase clinical trials have reported few complete responses. Potential reasons for the la