Výsledky vyhledávání - "Immunodeficiencies and autoimmunity"

Genetic dissection of a major haplotype associated with arthritis reveal FcγR2b and FcγR3 to act additively

Autor: Dorota Klaczkowska, Liselotte Bäckdahl, Rikard Holmdahl, Daniëlle Vaartjes, Kutty Selva Nandakumar, Mark S. Cragg

Publikováno v: European Journal of Immunology

A haplotype with tightly linked Fc gamma receptor (FcγR) genes is known as a major locus controlling immune responses and autoimmune diseases, including arthritis. Here, we split a congenic fragment derived from the NOD mouse (Cia9) to study its eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2547cad89eca407b310917fa1037e11a
https://doi.org/10.1002/eji.202048605

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Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti‐CD74 autoantibodies in human ankylosing spondylitis

Autor: Marianne Boes, Tessa S. van Kempen, Torsten Witte, Robert-Jan Lebbink, Timothy R D J Radstake, Christoph Driessen, Marthe F. S. Lindenbergh, Michel Olde Nordkamp, Emmerik F A Leijten, N.T. Baerlecken

Publikováno v: European Journal of Immunology

Ankylosing spondylitis (AS) is associated with autoantibody production to class II MHC‐associated invariant chain peptide, CD74/CLIP. In this study, we considered that anti‐CD74/CLIP autoantibodies present in sera from AS might recognize CD74 deg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d107f7aceb520967b660d1eacede5f4
http://europepmc.org/articles/PMC7496470

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CD4 + CCR6 + T cells, but not γδ T cells, are important for the IL‐23R‐dependent progression of antigen‐induced inflammatory arthritis in mice

Autor: Anne-Marie Mus, Wida Razawy, Erik Lubberts, Nicole Kops, Celso H. Alves, Nadine Davelaar, Nazike Salioska, Patrick S. Asmawidjaja, Mohamed Oukka

Publikováno v: European Journal of Immunology
European Journal of Immunology, 50, 245-255. Wiley-VCH

IL-23 plays an important role in the development of arthritis and the IL-23 receptor (IL-23R) is expressed on different types of T cells. However, it is not fully clear which IL-23R+ T cells are critical in driving T cell-mediated synovitis. We demon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c94b6f3d2c96705cdedbe6c1fe2beee
https://doi.org/10.1002/eji.201948112

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Enhancing immunity prevents virus‐induced T‐cell‐mediated immunopathology in B cell‐deficient mice

Autor: Hanspeter Pircher, Tobias Straub

Publikováno v: European Journal of Immunology

Hyper‐activated or deviated immune responses can result in immunopathological diseases. Paradoxically, immunodeficiency represents a frequent cause of such immune‐mediated pathologies. Immunopathological manifestations are commonly treated by imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44238c635e5c2eb99407267e335c2913
https://doi.org/10.1002/eji.201847962

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Circulating ILC precursors expressing CD62L exhibit a type 2 signature distinctly decreased in psoriatic patients

Autor: Stefania Campana, Bruno Galletti, Chiara Barberi, Claudia De Pasquale, Serafinella P. Cannavò, Giacomo Sidoti Migliore, Daniela Oliveri, Guido Ferlazzo, Claudio Guarneri

Publikováno v: European Journal of Immunology

Human CD117+CRTH2neg innate lymphoid cells (ILC) comprise multipotent precursors (ILCp), which are able to differentiate into subtypes in response to different signals received in peripheral tissues. NKp46+ ILCp have been reported to associate with I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b991ff2074de690b023c73182b8d9caa
https://pubmed.ncbi.nlm.nih.gov/33728641

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The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis

Autor: Liza Rijvers, Maeva Stéphant, Annet F Wierenga-Wolf, Jamie van Langelaar, Marvin M van Luijn, Marie-José Melief, Roos M van der Vuurst de Vries, Rogier Q. Hintzen, Anneke Geurts-Moespot, Fred C.G.J. Sweep, Jeanet M Hogervorst

Publikováno v: European Journal of Immunology, 48, 1861-1871
European Journal of Immunology
European Journal of Immunology, 48, 11, pp. 1861-1871
European Journal of Immunology, 48(11), 1861-1871. Wiley-VCH

In MS, B cells survive peripheral tolerance checkpoints to mediate local inflammation, but the underlying molecular mechanisms are relatively underexplored. In mice, the MIF pathway controls B‐cell development and the induction of EAE. Here, we fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a0aaaff9451f50063ce1a740fbb7d7
https://doi.org/10.1002/eji.201847623

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Aberrant cell signalling in PBMCs upon IFN‐α stimulation in primary Sjögren's syndrome patients associates with type I interferon signature

Autor: Silke Appel, Johan G. Brun, Daniel Hammenfors, Petra Vogelsang, Sonia Gavasso, Roland Jonsson, Richard Allan Davies, Brith Bergum

Publikováno v: European Journal of Immunology

Primary Sjögren's syndrome (pSS) is a complex systemic autoimmune disease with heterogeneous disease manifestations. Genetic predisposition, hormonal and environmental factors are all thought to contribute to disease etiology and pathogenesis. A bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6aae9387c8f0f567c2aaf6f71e8497f
http://europepmc.org/articles/PMC6585835

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Protein tyrosine phosphatase PTPN22 regulates IL‐1β dependent Th17 responses by modulating dectin‐1 signaling in mice

Autor: Purvis, Harriet A, Clarke, Fiona, Jordan, Christine K, Blanco, Cristina Sanchez, Cornish, Georgina H, Dai, Xuezhi, Rawlings, David J, Zamoyska, Rose, Cope, Andrew P

Publikováno v: European Journal of Immunology
Purvis, H A, Clarke, F, Jordan, C K, Blanco, C S, Cornish, G H, Dai, X, Rawlings, D J, Zamoyska, R & Cope, A P 2018, ' Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice ', European Journal of Immunology, vol. 48, no. 2, pp. 306-315 . https://doi.org/10.1002/eji.201747092

A single nucleotide polymorphism within the PTPN22 gene is a strong genetic risk factor predisposing to the development of multiple autoimmune diseases. PTPN22 regulates Syk and Src family kinases downstream of immuno-receptors. Fungal β-glucan rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::16dcdf9e64a3ebe020fd123326a56116
http://europepmc.org/articles/PMC5859948

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Human neonatal thymectomy induces altered B-cell responses and autoreactivity

Autor: Femke van Wijk, Kiki Tesselaar, Eveline M. Delemarre, Henny G. Otten, Frank A. Redegeld, Alvin W. L. Schadenberg, José A. M. Borghans, Nicolaas J. G. Jansen, Asaf Madi, Maura Rossetti, Rachel Sorek, Irun R. Cohen, Stefan Nierkens, Salvatore Albani, Theo van den Broek

Publikováno v: European Journal of Immunology

An association between T‐cell lymphopenia and autoimmunity has long been proposed, but it remains to be elucidated whether T‐cell lymphopenia affects B‐cell responses to autoantigens. Human neonatal thymectomy (Tx) results in a decrease in T‐

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9939fff4cc84576d707088705a7606ab
https://doi.org/10.1002/eji.201746971

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A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells

Autor: Philipp Haselmayer, Henry Hess, Michele Vigolo, Josquin Nys, Pascal Schneider

Publikováno v: Eur J Immunol
European Journal of Immunology, vol. 47, no. 6, pp. 1075-1085
European Journal of Immunology

The TNF family cytokines B‐cell activating factor (BAFF) and a proliferation‐inducing ligand (APRIL) support plasma cell survival. It is known that inhibitors of BAFF only (BAFFR‐Fc) or BAFF and APRIL (TACI‐Fc) administered early enough in an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09912e6f231d668db9785c2919c2d2a4
https://doi.org/10.1002/eji.201746934

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