Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins

Autor: Evgeniy S. Egorov, Aleksandra M. Walczak, Mikhail V. Pogorelyy, Ekaterina A Komech, Elena I. Kovalenko, Dmitriy M. Chudakov, Anastasia A. Minervina, Ilgar Z. Mamedov, Yuri B. Lebedev, Thierry Mora, Anastasiia L. Sycheva, A Komkov, Maximilian Puelma Touzel, Galina G. Karganova

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (50), pp.12704-12709. ⟨10.1073/pnas.1809642115⟩

Significance T cells play a key role in the adaptive immune system. The broad repertoire of unique receptors expressed by T cells is in principle able to recognize a huge diversity of pathogens, but how to extract that information from blood samples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee87c5e81a66a6788c67833e35864cd
https://doi.org/10.1073/pnas.1809642115

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin

Autor: Daniel Schnepf, Nils Lycke, Valentina Bernasconi, Hans Henrik Gad, Jan Becker, Yakup Tanriver, Karolina Ebert, Rune Hartmann, Liang Ye, Peter Staeheli

Publikováno v: Ye, L, Schnepf, D, Becker, J, Ebert, K, Tanriver, Y, Bernasconi, V, Gad, H H, Hartmann, R, Lycke, N & Staeheli, P 2019, ' Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin ', Nature Immunology, vol. 20, no. 5, pp. 593-601 . https://doi.org/10.1038/s41590-019-0345-x

Interferon-λ (IFN-λ) acts on mucosal epithelial cells and thereby confers direct antiviral protection. In contrast, the role of IFN-λ in adaptive immunity is far less clear. Here, we report that mice deficient in IFN-λ signaling exhibited impaire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ff9cbee59331ae55971b8a53ef7e1a
https://pure.au.dk/portal/da/publications/interferon-enhances-adaptive-mucosal-immunity-by-boosting-release-of-thymic-stromal-lymphopoietin(103ab490-cd68-4f02-8921-47100722608f).html

Immunization Handbook for Pharmacists, 4th Edition

Autor: Lauren B. Angelo

As policies and laws related to vaccination change, pharmacists have increased opportunities to educate and vaccinate persons in their community. And with changes in available vaccines, immunization schedules, and dosing and administration recommenda

Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner

Autor: Haiping Wang, Benjamin P. Hurrell, Stefanie Siegert, Manuel Coutaz, Ping-Chih Ho, Fabienne Tacchini-Cottier, Gérard Eberl, Freddy Radtke, Floriane Auderset

Publikováno v: Scientific Reports
Scientific reports, vol. 6, pp. 39117

Th17 cells play critical roles in host defense and autoimmunity. Emerging data support a role for Notch signaling in Th17 cell differentiation but whether it is a positive or negative regulator remains unclear. We report here that T cell-specific del

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b4ffe619c2b0fb1fe024c609e394fa

Recurrence of Cardiorespiratory Events following Repeat DTaP-Based Combined Immunization in Very Low Birth Weight Premature Infants

Autor: Claire-Anne Siegrist, Riccardo Pfister, Aline Flatz-Jequier, Klara M. Posfay-Barbe

Publikováno v: The Journal of Pediatrics, Vol. 153, No 3 (2008) pp. 429-431

We evaluated the tolerance to immunization of 64 very low birth weight preterm infants. Thirty-three of the infants experienced a cardiorespiratory event after the first vaccination, and 6 of these 33 (18%) had a recurrence after the second vaccinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fa09f9e46d81f8446c02150fe91980
https://doi.org/10.1016/j.jpeds.2008.03.043