Zobrazeno 1 - 10
of 920
pro vyhledávání: '"Immune resistance"'
Publikováno v:
Medičnì Perspektivi, Vol 29, Iss 3, Pp 108-117 (2024)
The aim of the study is to identify and evaluate the general immunological reactivity of patients with COVID-19 and its relationship with gene polymorphism, severity of the clinical course of the disease and combination with comorbidities. A cohort s
Externí odkaz:
https://doaj.org/article/9c8f3f57110e470c93171a7b636ecace
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Aims To investigate whether the addition of radiotherapy could be an appropriate option to delay the time-to-next systemic treatment (TTNsT) in patients with oligoprogressive solid tumors who had acquired or innate resistance to immune check
Externí odkaz:
https://doaj.org/article/3b9ee1413815493f9b35f79683397731
Autor:
Bingyu Wang, Wenbo Liu, Mingming Zhang, Yong Li, Hongyue Tang, Yingying Wang, Chao Song, Buyun Song, Bibo Tan
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background While small extracellular vesicles (sEVs)-derived circular RNAs (circRNAs) have been emerged as significant players in cancer, the function and underlying mechanism of sEVs-derived circRNAs in anti-cancer immunity remain unclear.
Externí odkaz:
https://doaj.org/article/d46d700692fd433ea7adddbd38bae2c3
Autor:
Jin Su, Xinyuan Mao, Lingzhi Wang, Zhian Chen, Weisheng Wang, Cuiyin Zhao, Guoxin Li, Weihong Guo, Yanfeng Hu
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Lactate plays an important role in shaping immune tolerance in tumor microenvironment (TME) and correlates with poor prognosis in various solid tumors. Overcoming the immune resistance in an acidic TME may improve the anti-tumor immunity. Here, this
Externí odkaz:
https://doaj.org/article/96252f6eb5c14c9c8fc4d3d0f57c5f8c
Autor:
Moumita Kundu, Ramesh Butti, Venketesh K. Panda, Diksha Malhotra, Sumit Das, Tandrima Mitra, Prachi Kapse, Suresh W. Gosavi, Gopal C. Kundu
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-27 (2024)
Abstract Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer is more challenging and may be unresponsive to conventional therapy. Immunotherapy is crucial for
Externí odkaz:
https://doaj.org/article/94a1bff0be6b40b1a800fcd907a43436
Autor:
Qingshan Chen, Fenglin Gao, Junwan Wu, Kaiming Zhang, Tian Du, Yuhong Chen, Ruizhao Cai, Dechang Zhao, Rong Deng, Jun Tang
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background Mitochondrial outer membrane permeabilisation (MOMP) plays a pivotal role in cellular death and immune activation. A deeper understanding of the impact of tumour MOMP on immunity will aid in guiding more effective immunotherapeuti
Externí odkaz:
https://doaj.org/article/43ecb89d02374b6f822f97327af205c5
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e31299- (2024)
The high heterogeneity of lung squamous cell carcinomas (LUSC) and the complex tumor microenvironment lead to non-response to immunotherapy in many patients. Therefore, characterizing the heterogeneity of the tumor microenvironment in patients with L
Externí odkaz:
https://doaj.org/article/68710586ad0741c9829aec69bbbfb253
Autor:
Xin‐Yu Chen, Bin Li, Ye Wang, Juan Jin, Yu Yang, Lei‐Huan Huang, Meng‐Di Yang, Jian Zhang, Bi‐Yun Wang, Zhi‐Ming Shao, Ting Ni, Sheng‐Lin Huang, Xi‐Chun Hu, Zhong‐Hua Tao
Publikováno v:
Cancer Communications, Vol 43, Iss 9, Pp 1003-1026 (2023)
Abstract Background Immune checkpoint inhibitors (ICIs) shed new light on triple‐negative breast cancer (TNBC), but only a minority of patients demonstrate response. Therefore, adaptive immune resistance (AIR) needs to be further defined to guide t
Externí odkaz:
https://doaj.org/article/c221d8e67a8c4f0f8837a2b805d09448
Autor:
Ayse N. Menevse, Laura-Marie Ammer, Arabel Vollmann-Zwerenz, Marcell Kupczyk, Julia Lorenz, Lorraine Weidner, Abir Hussein, Julian Sax, Jasmin Mühlbauer, Nicole Heuschneider, Celine Rohrmus, Laura S. Mai, Birgit Jachnik, Slava Stamova, Valentina Volpin, Franziska C. Durst, Antonio Sorrentino, Maria Xydia, Vladimir M. Milenkovic, Stefanie Bader, Frank K. Braun, Christian Wetzel, Nathalie L. Albert, Joerg-Christian Tonn, Peter Bartenstein, Martin Proescholdt, Nils O. Schmidt, Ralf A. Linker, Markus J. Riemenschneider, Philipp Beckhove, Peter Hau
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-23 (2023)
Abstract Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with malignancy and poor prognosis, but
Externí odkaz:
https://doaj.org/article/5b085ac5cc8b49e9922c86d6fca1cd96
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 49, Iss 6, Pp 546-551 (2022)
Immunotherapy is considered as the fourth cancer treatment after surgery, radiotherapy and chemotherapy. With the in-depth research on immunotherapy in recent years, especially immuno-checkpoint inhibitors, PD-1/PD-L1 pathway inhibitors have been app
Externí odkaz:
https://doaj.org/article/95f31bf1beb7424882925b003fb083ad