Zobrazeno 1 - 10
of 4 640
pro vyhledávání: '"Immune Checkpoints"'
Autor:
Yuan Tian, Shenghui Qiu, Song Yang, Yuanjian Jiang, Hao Hu, Chengcheng Yang, Jinyong Cao, Shaomin Chen, Mingqing Hao, Hongling Li, Jianlin Zhu
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Stomach adenocarcinoma (STAD) is known for its high prevalence and poor prognosis, which underscores the need for novel therapeutic targets. Peroxidasin (PXDN), an enzyme with peroxidase activity, has been linked to cancer development in pre
Externí odkaz:
https://doaj.org/article/1b7a11bbee9846999b42e995b77d5e5f
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Ferroptosis is a novel type of programmed cell death in various tumors; however, underlying mechanisms remain unclear. We aimed to develop ferroptosis-related long non-coding RNA (FRlncRNA) risk scores to predict lower-grade gliom
Externí odkaz:
https://doaj.org/article/3c7bb3df6cd54eacb7c19016d12426c9
Autor:
Piyada Sitthideatphaiboon, Nicha Somlaw, Nicha Zungsontiporn, Pongsakorn Ouwongprayoon, Narittee Sukswai, Krittiya Korphaisarn, Naravat Poungvarin, Chatchawit Aporntewan, Nattiya Hirankarn, Chanida Vinayanuwattikun, Vinayanuwattikun Chanida
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Gut microbiota is considered a key player modulating the response to immune checkpoint inhibitors (ICI) in cancer. The effects of dietary pattern on this interaction is not well-studied. A prospective multicenter cohort of 95 patients with a
Externí odkaz:
https://doaj.org/article/482c069cc9b44a9f87daa90e16e99eb3
Autor:
Yoel G. Montoyo-Pujol, José J. Ponce, Silvia Delgado-García, Tina A. Martín, Hortensia Ballester, Elena Castellón-Molla, Angela Ramos-Montoya, Inmaculada Lozano-Cubo, J. Miguel Sempere-Ortells, Gloria Peiró
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Breast cancer (BC) is the most common cancer in women and the leading cause of cancer-related death worldwide. This heterogeneous disease has been historically considered a non-immunogenic type of cancer. However, recent advances
Externí odkaz:
https://doaj.org/article/b0cac6e2fee34109ace9abac8a8c2307
Autor:
Joao Gorgulho, Sven H. Loosen, Ramsha Masood, Franziska Giehren, Francesca Pagani, Gustav Buescher, Lorenz Kocheise, Vincent Joerg, Constantin Schmidt, Kornelius Schulze, Christoph Roderburg, Eva Kinkel, Britta Fritzsche, Simon Wehmeyer, Benjamin Schmidt, Paul Kachel, Christina Rolling, Julian Götze, Alina Busch, Marianne Sinn, Thais Pereira-Veiga, Harriet Wikman, Maria Geffken, Sven Peine, Urte Matschl, Markus Altfeld, Samuel Huber, Ansgar W. Lohse, Fabian Beier, Tim H. Brümmendorf, Carsten Bokemeyer, Tom Luedde, Johann von Felden
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)
Abstract Background The major breakthrough in cancer therapy with immune checkpoint inhibitors (ICIs) has highlighted the important role of immune checkpoints in antitumoral immunity. However, most patients do not achieve durable responses, making bi
Externí odkaz:
https://doaj.org/article/c2fb5d5ae25641debf5ff764186a0fca
Autor:
Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Background Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, me
Externí odkaz:
https://doaj.org/article/324b033e9fa34bbcab45721b8054a03a
Autor:
Xingcheng Yang, Lijun Jiang, Xiaoying Zhang, Juan Peng, Hu Qian, Lifang Huang, Shaolong He, Zhiqiong Wang, Liting Chen, Yicheng Zhang, Ling Ma, Yuan Chen, Jia Wei
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-5 (2024)
Abstract The role of the compromised immune microenvironment, including immune checkpoints, in myelodysplastic syndromes (MDS) has been identified as critical This study aimed to investigate the expression patterns of immune checkpoints, particularly
Externí odkaz:
https://doaj.org/article/0c0886bf71d24e7fb1a80567baeefd78
Publikováno v:
Molecular Oncology, Vol 18, Iss 10, Pp 2338-2355 (2024)
MYC has been implicated in the pathogenesis of a wide range of human tumors and has been described for many years as a transcription factor that regulates genes with pleiotropic functions to promote tumorigenic growth. However, despite extensive effo
Externí odkaz:
https://doaj.org/article/0db5518ccb4c4c76ba0a8d56e3244828
Autor:
Beibei Li, Rongkai Li
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Background Snail family zinc finger 1 (SNAI1) has been implicated in cancer progression and prognosis across various malignancies. This study aims to elucidate the prognostic significance of SNAI1 expression in Lung Squamous Cell Carcinoma (
Externí odkaz:
https://doaj.org/article/6c9ca778b81743a7abb992c64ab26b8e
Autor:
V. V. Babinsky
Publikováno v:
Acta Biomedica Scientifica, Vol 9, Iss 4, Pp 69-74 (2024)
Background. Autoimmune thyroiditis (AIT) affects more than 5 % of the world’s population.The aim. To determine the level of sPD-1, sPD-L1, sCTLA-4 and sB7.2 molecules in individuals suffering from various forms of autoimmune thyroiditis.Methods. Th
Externí odkaz:
https://doaj.org/article/90dee70109654d96a62e5b50d97dd546