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pro vyhledávání: '"Immobilized Artificial Membrane"'
Akademický článek
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Akademický článek
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Autor:
Pramod Thakare, Francesca Vasile, Maura Vallaro, Sonja Visentin, Giulia Caron, Emanuela Licandro, Silvia Cauteruccio
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 11, Iss 5, Pp 638-645 (2021)
The first combined experimental and theoretical study on the ionization and lipophilic properties of peptide nucleic acid (PNA) derivatives, including eleven PNA monomers and two PNA decamers, is described. The acidity constants (pKa) of individual a
Externí odkaz:
https://doaj.org/article/4bbefb3bc2e94a5e950c7baea6f69da5
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1172 (2023)
Chromatographic retention data collected on immobilized keratin (KER) or immobilized artificial membrane (IAM) stationary phases were used to predict skin permeability coefficient (log Kp) and bioconcentration factor (log BCF) of structurally unrelat
Externí odkaz:
https://doaj.org/article/f8494ceed3b14c55bb23db8a5ce0db00
Autor:
Anna W. Sobańska
Publikováno v:
Membranes, Vol 12, Iss 11, p 1130 (2022)
The BCF (bioconcentration factor) of solutes in aquatic organisms is an important parameter because many undesired chemicals enter the ecosystem and affect the wildlife. Chromatographic retention factor log kwIAM obtained from immobilized artificial
Externí odkaz:
https://doaj.org/article/4f93e14c0d924f00a42a6bd395352578
Publikováno v:
Chemosensors, Vol 10, Iss 8, p 340 (2022)
Lipophilicity is one of many parameters involved in the biological activity of drugs, as it affects their pharmacokinetic and pharmacodynamic behavior. Generally, lipophilicity is assessed by the partition coefficient of a compound between a nonpolar
Externí odkaz:
https://doaj.org/article/f600453428344c11981cf6ff5fb4070c
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 965 (2022)
In the present study, various procedures have been compared for the determination of lipophilicity, hydrophobicity, and plasma protein binding of curcuminoids, boswellic acids, andrographolides, and piperine as biologically active ingredients of bota
Externí odkaz:
https://doaj.org/article/ef4544cfeedb499fa1196073b9e3a605
Autor:
Anna W. Sobańska, Elżbieta Brzezińska
Publikováno v:
Molecules, Vol 27, Iss 6, p 1893 (2022)
Chromatographic retention factor log kIAM obtained from IAM HPLC chromatography with buffered aqueous mobile phases and calculated molecular descriptors (surface area—Sa; molar volume—VM; polar surface area—PSA; count of freely rotable bonds—
Externí odkaz:
https://doaj.org/article/7c9067f057334a4db7bc3345f0f6023b
Publikováno v:
ADMET and DMPK, Vol 6, Iss 2, Pp 162-175 (2018)
Peptide therapeutics are new modalities offering several challenges to drug discovery. They are generally less stable and permeable in vivo. The characterization of their lipophilicity cannot be carried out using the traditional in silico or wet octa
Externí odkaz:
https://doaj.org/article/25db73c14ddd4978b847987a350abe13
Publikováno v:
ADMET and DMPK, Vol 6, Iss 2, Pp 190-199 (2018)
Development of the first peptide retention prediction model for immobilized artificial membrane phosphatidylcholine (IAM.PC) stationary phase is reported. 2D LC-MS/MS analysis of a whole cell lysate of S. cerevisiae yielded a retention dataset of ~29
Externí odkaz:
https://doaj.org/article/2ead71a093c6401aba000476558b206c