Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Immo E. Scheffler"'
Autor:
Priya Prakash Karmali, Immo E. Scheffler, Valentina Fogal, Jeffrey W. Smith, Erkki Ruoslahti, Adam D. Richardson
Publikováno v:
Molecular and cellular biology. 37(14)
p32/gC1qR/C1QBP/HABP1 is a mitochondrial/cell surface protein overexpressed in certain cancer cells. Here we show that knocking down p32 expression in human cancer cells strongly shifts their metabolism from oxidative phosphorylation (OXPHOS) to glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8dcad84418db23a3eb4b2b516f7dee6
https://pubmed.ncbi.nlm.nih.gov/20100866
https://pubmed.ncbi.nlm.nih.gov/20100866
Publikováno v:
Biochimica et biophysica acta, vol 1857, iss 8
To identify nuclear DNA (nDNA) oxidative phosphorylation (OXPHOS) gene mutations using cultured cells, we have developed a complementation system based on retroviral transduction with a full length cDNA expression library and selection for OXHOS func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e41e8c67aed8757838724c5c099ba5
https://escholarship.org/uc/item/50j787tx
https://escholarship.org/uc/item/50j787tx
Autor:
Harriet M. Kluger, Eric Lau, David L. Rimm, Trey Ideker, Ki-Young Lee, Ze'ev Ronai, Tal Varsano, Immo E. Scheffler
Publikováno v:
Cell. 148:543-555
SummaryThe transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e3c6bc980198f97071e32287f431cb
https://doi.org/10.1016/j.cell.2012.01.016
https://doi.org/10.1016/j.cell.2012.01.016
Autor:
D. Joseph Jerry, Immo E. Scheffler, Shannon Compton, Nagendra Yadava, Sallie S. Schneider, Nicholas B. Griner, Chul Kim, Prasanth Potluri, Sabyasachi Sen
Publikováno v:
The Journal of biological chemistry, vol 286, iss 23
Recently, mitochondria have been suggested to act in tumor suppression. However, the underlying mechanisms by which mitochondria suppress tumorigenesis are far from being clear. In this study, we have investigated the link between mitochondrial dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6a340e90906c45acb458b6071b1ab8
https://doi.org/10.1074/jbc.m110.163063
https://doi.org/10.1074/jbc.m110.163063
Autor:
Mariella Simon, Dan Mishmar, Eduardo Ruiz-Pesini, Antonio Davila, Prasanth Potluri, Saege Hancock, Vincent Procaccio, Douglas C. Wallace, Immo E. Scheffler, Sean O’Hearn
Publikováno v:
Molecular genetics and metabolism, vol 96, iss 4
Mitochondrial diseases have been shown to result from mutations in mitochondrial genes located in either the nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). Mitochondrial OXPHOS complex I has 45 subunits encoded by 38 nuclear and 7 mitochondrial gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8eee882e5950f49485f4f63f7468c0e
https://doi.org/10.1016/j.ymgme.2008.12.004
https://doi.org/10.1016/j.ymgme.2008.12.004
Autor:
Karel Valis, Ruth Freeman, Bevan Butcher, Rafael Moreno-Sánchez, Renata Zobalova, Ji Liu, Ulf T. Brunk, Marina Stantic, Stephen John Ralph, Paul K. Witting, Jacob Goodwin, Jiri Neuzil, Jakub Rohlena, Lan-Feng Dong, Alvaro Marín-Hernández, Sara Rodríguez-Enríquez, Immo E. Scheffler
Publikováno v:
Clinical Cancer Research. 15:1593-1600
Purpose: Vitamin E analogues are potent novel anticancer drugs. The purpose of this study was to elucidate the cellular target by which these agents, represented by α-tocopoheryl succinate (α-TOS), suppress tumors in vivo, with the focus on the mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7efd200d3bc4bd45e00498ad394c5a
https://doi.org/10.1158/1078-0432.ccr-08-2439
https://doi.org/10.1158/1078-0432.ccr-08-2439
Autor:
Renata Zobalova, Jiri Neuzil, Paul K. Witting, Jaroslav Turánek, Jeffrey Clifford Dyason, Emma Swettenham, Ji Liu, Lubomir Prochazka, Pauline Low, Stephen John Ralph, Immo E. Scheffler, Karel Valis, Ruth Freeman, Lan-Feng Dong, Xiu-Fang Wang, Doug Spitz, Frederick E. Domann
Publikováno v:
Oncogene. 27:4324-4335
Alpha-tocopheryl succinate (alpha-TOS) is a selective inducer of apoptosis in cancer cells, which involves the accumulation of reactive oxygen species (ROS). The molecular target of alpha-TOS has not been identified. Here, we show that alpha-TOS inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaae5167cdfb9b870220613160226f6
https://doi.org/10.1038/onc.2008.69
https://doi.org/10.1038/onc.2008.69
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 40:447-460
There have been several reports on the phosphorylation of various subunits of NADH-ubiquinone oxidoreductase (complex I) in mammalian mitochondria. The effects of phosphorylation on assembly or activity of these subunits have not been investigated di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dab58b14c666b61b811a47822018e9a
https://doi.org/10.1016/j.biocel.2007.08.015
https://doi.org/10.1016/j.biocel.2007.08.015
Autor:
Xiangli Li, Vincent Giguère, Ling Wa Chong, Josée Laganière, Chih-Hao Lee, Isaac R. Mehl, Alain R. Bataille, Ronald M. Evans, Immo E. Scheffler, Grant D. Barish, Dennis Mock, François Robert, Junichiro Sonoda
Publikováno v:
Genes & Development. 21:1909-1920
Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature of the IFN-gamma-induced activation pathway is not known. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0882171aaaba4d8c4d55c81b82639dd5
https://doi.org/10.1101/gad.1553007
https://doi.org/10.1101/gad.1553007
Autor:
Prasanth Potluri, Renate B. Pilz, Gerry R. Boss, Vijay S. Sharma, Immo E. Scheffler, Shunhui Zhuang, Kate E. Broderick
Publikováno v:
Experimental Biology and Medicine. 231:641-649
Cyanide is a highly toxic agent that inhibits mitochondrial cytochrome-c oxidase, thereby depleting cellular ATP. it contributes to smoke inhalation deaths in fires and could be used as a weapon of mass destruction. Cobalamin (vitamin B12) binds cyan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5eb93bf59a8826b567422e58b20c80
https://doi.org/10.1177/153537020623100519
https://doi.org/10.1177/153537020623100519