Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3.

Autor: Bastian Stielow, Imme Krüger, Rolf Diezko, Florian Finkernagel, Nynke Gillemans, John Kong-a-San, Sjaak Philipsen, Guntram Suske

Publikováno v: PLoS Genetics, Vol 6, Iss 11, p e1001203 (2010)

SUMO modification of transcription factors is linked to repression of transcription. The physiological significance of SUMO attachment to a particular transcriptional regulator, however, is largely unknown. We have employed the ubiquitously expressed

Externí odkaz: https://doaj.org/article/9e85d90ff03d42879c120e667850bfeb

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function

Autor: Erikjan Rijkers, Laura Gutierrez, Hans Janssen, Harmen J.G. van de Werken, Marjolein Meinders, Rutger W W Brouwer, Guntram Suske, Timo K. van den Berg, Sjaak Philipsen, Wilfred F. J. van IJcken, Mark Hoogenboezem, Imme Krüger, Jeroen Demmers, Divine I. Kulu

Publikováno v: Meinders, M, Kulu, D I, van de Werken, H J G, Hoogenboezem, M, Janssen, H, Brouwer, R W W, van Ijcken, W F J, Rijkers, E-J, Demmers, J A A, Krüger, I, van den Berg, T K, Suske, G, Gutiérrez, L & Philipsen, S 2015, ' Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function ', Blood, vol. 125, no. 12, pp. 1957-67 . https://doi.org/10.1182/blood-2014-08-593343
Blood, 125(12), 1957-67. American Society of Hematology
Blood, 125(12), 1957-1967. American Society of Hematology

Sp1 and Sp3 belong to the specificity proteins (Sp)/Krüppel-like transcription factor family. They are closely related, ubiquitously expressed, and recognize G-rich DNA motifs. They are thought to regulate generic processes such as cell-cycle and gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c85d0eab4bc6061f2c10f309f303862
https://doi.org/10.1182/blood-2014-08-593343

Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNA interference screen

Autor: Alexandra Sapetschnig, Imme Krüger, Bastian Stielow, Guntram Suske, Michael Boutros

Publikováno v: GBM Annual Spring meeting Mosbach 2008. 2008

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e96a24ccb6dba1ec969705217c734837
https://doi.org/10.1240/sav_gbm_2008_m_002141

Specificity Protein 2 (Sp2) Is Essential for Mouse Development and Autonomous Proliferation of Mouse Embryonic Fibroblasts

Autor: Kerstin Nau, Guntram Suske, Frank Baur, Imme Krüger, Hans-Peter Elsässer, Dennis Sadic, Sjaak Philipsen, Marion Vollmer, Nynke Gillemans, Lena Allweiss, Ton de Wit

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 3, p e9587 (2010)

BACKGROUND: The zinc finger protein Sp2 (specificity protein 2) is a member of the glutamine-rich Sp family of transcription factors. Despite its close similarity to Sp1, Sp3 and Sp4, Sp2 does not bind to DNA or activate transcription when expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ae6fa2b52f5bd6a64e5a96129be5b0
https://doi.org/10.1371/journal.pone.0009587