Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3.

Autor: Bastian Stielow, Imme Krüger, Rolf Diezko, Florian Finkernagel, Nynke Gillemans, John Kong-a-San, Sjaak Philipsen, Guntram Suske

Publikováno v: PLoS Genetics, Vol 6, Iss 11, p e1001203 (2010)

SUMO modification of transcription factors is linked to repression of transcription. The physiological significance of SUMO attachment to a particular transcriptional regulator, however, is largely unknown. We have employed the ubiquitously expressed

Externí odkaz: https://doaj.org/article/9e85d90ff03d42879c120e667850bfeb

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function

Autor: Erikjan Rijkers, Laura Gutierrez, Hans Janssen, Harmen J.G. van de Werken, Marjolein Meinders, Rutger W W Brouwer, Guntram Suske, Timo K. van den Berg, Sjaak Philipsen, Wilfred F. J. van IJcken, Mark Hoogenboezem, Imme Krüger, Jeroen Demmers, Divine I. Kulu

Publikováno v: Meinders, M, Kulu, D I, van de Werken, H J G, Hoogenboezem, M, Janssen, H, Brouwer, R W W, van Ijcken, W F J, Rijkers, E-J, Demmers, J A A, Krüger, I, van den Berg, T K, Suske, G, Gutiérrez, L & Philipsen, S 2015, ' Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function ', Blood, vol. 125, no. 12, pp. 1957-67 . https://doi.org/10.1182/blood-2014-08-593343
Blood, 125(12), 1957-67. American Society of Hematology
Blood, 125(12), 1957-1967. American Society of Hematology

Sp1 and Sp3 belong to the specificity proteins (Sp)/Krüppel-like transcription factor family. They are closely related, ubiquitously expressed, and recognize G-rich DNA motifs. They are thought to regulate generic processes such as cell-cycle and gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c85d0eab4bc6061f2c10f309f303862
https://doi.org/10.1182/blood-2014-08-593343

Sp1/Sp3 compound heterozygous mice are not viable: Impaired erythropoiesis and severe placental defects

Autor: Imme, Krüger, Marion, Vollmer, David G, Simmons, David, Simmons, Hans-Peter, Elsässer, Sjaak, Philipsen, Guntram, Suske

Publikováno v: Developmental Dynamics, 236(8), 2235-2244. Wiley-Liss Inc.

The ubiquitously expressed zinc finger transcription factors Sp1 and Sp3 play critical roles in embryonic development. Sp1 knockout mice die around embryonic day 10.5. Mice lacking Sp3 are postnatal lethal. Mice heterozygous for either Sp1 or Sp3 are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5269e30f9529b13072634e34979ddf91
https://pure.eur.nl/en/publications/a17594c3-f625-4853-bfc0-bac248954a7d

Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNA interference screen

Autor: Alexandra Sapetschnig, Imme Krüger, Bastian Stielow, Guntram Suske, Michael Boutros

Publikováno v: GBM Annual Spring meeting Mosbach 2008. 2008

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e96a24ccb6dba1ec969705217c734837
https://doi.org/10.1240/sav_gbm_2008_m_002141

Epigenetic Silencing of Spermatocyte-Specific and Neuronal Genes by SUMO Modification of the Transcription Factor Sp3

Autor: Nynke Gillemans, Sjaak Philipsen, John Kong-a-San, Florian Finkernagel, Rolf Diezko, Bastian Stielow, Guntram Suske, Imme Krüger

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 6, Iss 11, p e1001203 (2010)
PLoS Genetics (print), 6(11). Public Library of Science

SUMO modification of transcription factors is linked to repression of transcription. The physiological significance of SUMO attachment to a particular transcriptional regulator, however, is largely unknown. We have employed the ubiquitously expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b642dd0a0531914456428b95b2fd809
https://doi.org/10.1371/journal.pgen.1001203