Genetic vaccination by gene electro-transfer in non-human primates

Autor: Alfredo Nicosia, John W. Shiver, Gary S. Kath, Adam J. Simon, Elena Fattori, Gennaro Ciliberto, Danilo R. Casimiro, Immacolata Zampaglione, Adam C. Finnefrock, Aimin Tang, N. La Monica, R Cortese, Antonella Folgori, Stefania Capone

Publikováno v: Scopus-Elsevier

Muscle gene electro-transfer (GET) of plasmid DNA is a promising approach for gene therapy and genetic vaccination. Several protocols have been described which give good levels of gene transduction in small animals. However, to progress towards human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3397e93c42948bf3dde46944b860d1
https://doi.org/10.1016/s1773-2247(06)50013-9

Construction of an rtTA2s-m2/ttskid-Based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and Non-Human primates

Autor: Odalys Gonzalez Paz, Stefania Lamartina, Hermann Bujard, Danilo R. Casimiro, Gennaro Ciliberto, John W. Shiver, Guiseppe Roscilli, Mary Ellen Davies, Stefano Colloca, Cira Daniela Rinaudo, Adam J. Simon, Luisa Silvi, Carlo Toniatti, Elena Fattori, Riccardo Cortese, Immacolata Zampaglione, Ralph Laufer

Publikováno v: Molecular Therapy. 7:271-280

The tetracycline (Tc)-dependent system in its "on" version (rtTA system) displays a baseline activity in the uninduced state, severely limiting its potential applicability in human gene therapy. So far, two different strategies to circumvent this lim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87867678834eeb73cfd76fc874220fb
https://doi.org/10.1016/s1525-0016(02)00051-5

Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates

Autor: Immacolata Zampaglione, Elena Fattori, Manuela Cappelletti, Gennaro Ciliberto, Patrizia Costa, Nicola La Monica, Gemma Perretta, Gabriella Rizzuto, Francesco Calvaruso, Carmela Mennuni, Mirko Arcuri

Publikováno v: The journal of gene medicine 7/2 (2005): 228–236. doi:10.1002/jgm.652
info:cnr-pdr/source/autori:Fattori E.1, Cappelletti M.2, Zampaglione I.3, Mennuni C.4, Calvaruso F.5, Arcuri M.6, Rizzuto G.7, Costa P.8, Perretta G.9, Ciliberto G.10, La Monica N.11/titolo:Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates./doi:10.1002%2Fjgm.652/rivista:The journal of gene medicine/anno:2005/pagina_da:228/pagina_a:236/intervallo_pagine:228–236/volume:7%2F2

BACKGROUND: Anemia due to impaired erythropoietin (EPO) production is associated with kidney failure. Recombinant proteins are commonly administered to alleviate the symptoms of this dysfunction, whereas gene therapy approaches envisaging the deliver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a16fdcb114094b3e29ce8ed8501167d
https://pubmed.ncbi.nlm.nih.gov/15515133

Hyaluronidase increases electrogene transfer efficiency in skeletal muscle

Autor: Ernesta Dammassa, Francesco Calvaruso, Gabriella Rizzuto, Gennaro Ciliberto, Elena Fattori, Nicola La Monica, Immacolata Zampaglione, C. Daniela Rinaudo, Carmela Mennuni

Publikováno v: Human gene therapy. 13(3)

Electrogene transfer (EGT) of plasmid DNA into skeletal muscle is a promising strategy for the treatment of muscle disorders and for the systemic secretion of therapeutic proteins. We report here that preinjecting hyaluronidase (HYAse) significantly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0bae2701b4276991f8201d2a4fc5ce
https://pubmed.ncbi.nlm.nih.gov/11860703

ErbB2 Genetic Cancer Vaccine in Nonhuman Primates: Relevance of Single Nucleotide Polymorphisms.

Autor: Elena Fattori, Luigi Aurisicchio, Immacolata Zampaglione, Mirko Arcuri, Manuela Cappelletti, Barbara Cipriani, Carmela Mennuni, Francesco Calvaruso, Maurizio Nuzzo, Gennaro Ciliberto, Paolo Monaci, Nicola La Monica

Publikováno v: Human Gene Therapy; Mar2009, Vol. 20 Issue 3, p253-265, 13p