Innovative Biocatalysts as Tools to Detect and Inactivate Nerve Agents

Autor: Valentina De Luca, Piero Porcaro, Elena Porzio, Franz Worek, Ilaria Palchetti, Antonio Pisanti, Giuseppe Manco, Teresa Maria Carusone, Immacolata Del Giudice, Mario De Rosa, Odile F. Restaino, Maria Giovanna Borzacchiello, Chiara Schiraldi, Serena Laschi, Francesca Bettazzi, Luigi Mandrich, Ferdinando Febbraio

Publikováno v: 13th International Meeting on Cholinesterases-7th International Conference on Paraoxonases", 9-14/9/2018.
info:cnr-pdr/source/autori:Elena Porzio1*, Francesca Bettazzi2*, Luigi Mandrich1, Immacolata Del Giudice1, Odile F. Restaino3, Serena Laschi4, Ferdinando Febbraio1, Valentina De Luca1, Maria G. Borzacchiello3, Teresa M. Carusone1, Franz Worek5, Antonio Pisanti6, Piero Porcaro6, Chiara Schiraldi3, Mario De Rosa3, Ilaria Palchetti2, Giuseppe Manco1#/congresso_nome:13th International Meeting on Cholinesterases-7th International Conference on Paraoxonases"/congresso_luogo:/congresso_data:9-14%2F9%2F2018./anno:2018/pagina_da:/pagina_a:/intervallo_pagine
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific reports (Nature Publishing Group) 8 (2018). doi:10.1038/s41598-018-31751-5
info:cnr-pdr/source/autori:Porzio, Elena; Bettazzi, Francesca; Mandrich, Luigi; Del Giudice, Immacolata; Restaino, Odile F.; Laschi, Serena; Febbraio, Ferdinando; De Luca, Valentina; Borzacchiello, Maria G.; Carusone, Teresa M.; Worek, Franz; Pisanti, Antonio; Porcaro, Piero; Schiraldi, Chiara; De Rosa, Mario; Palchetti, Ilaria; Manco, Giuseppe/titolo:Innovative Biocatalysts as Tools to Detect and Inactivate Nerve Agents/doi:10.1038%2Fs41598-018-31751-5/rivista:Scientific reports (Nature Publishing Group)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:8

Pesticides and warfare nerve agents are frequently organophosphates (OPs) or related compounds. Their acute toxicity highlighted more than ever the need to explore applicable strategies for the sensing, decontamination and/or detoxification of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3fcd48f5d1f1f0d577df6710f040cc
http://www.cnr.it/prodotto/i/393478

Conformational stability and ligand binding properties of BldR, a member of the MarR family, from Sulfolobus solfataricus

Autor: Pompea Del Vecchio, Luigi Petraccone, Gabriella Fiorentino, Immacolata Del Giudice, Simonetta Bartolucci

Publikováno v: Biochimica et biophysica acta. Proteins and proteomics 1844 (2014): 1167–1172. doi:10.1016/j.bbapap.2014.03.011
info:cnr-pdr/source/autori:Fiorentino, Gabriella; Del Giudice, Immacolata; Petraccone, Luigi; Bartolucci, Simonetta; Del Vecchio, Pompea/titolo:Conformational stability and ligand binding properties of BldR, a member of the MarR family, from Sulfolobus solfataricus/doi:10.1016%2Fj.bbapap.2014.03.011/rivista:Biochimica et biophysica acta. Proteins and proteomics/anno:2014/pagina_da:1167/pagina_a:1172/intervallo_pagine:1167–1172/volume:1844

The multiple antibiotic resistance regulators (MarR) constitute a family of ligand-responsive transcriptional regulators ubiquitous among the bacterial and archaeal domains. BldR, an archaeal MarR member characterized from the hyperthermophilic crena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d30e98fd53870d5ed9ec01cdf24da19
https://doi.org/10.1016/j.bbapap.2014.03.011

Engineering of Extremophilic Phosphotriesterase-Like Lactonases for Biotechnological Applications

Autor: Immacolata Del Giudice, Elena Porzio, Giuseppe Manco

Publikováno v: Biotechnology of Extremophiles: ISBN: 9783319135205

Organophosphate compounds, as most pesticides and chemical warfare agents, first appeared in the US after 1930s and became widespread after World War II. At present, enzymatic detoxification of organophosphate compounds represents an important issue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce884133d7cbb3a868f685976d772781
https://doi.org/10.1007/978-3-319-13521-2_16

An efficient thermostable organophosphate hydrolase and its application in pesticide decontamination

Autor: Immacolata, Del Giudice, Rossella, Coppolecchia, Luigia, Merone, Elena, Porzio, Teresa Maria, Carusone, Luigi, Mandrich, Franz, Worek, Giuseppe, Manco

Publikováno v: Biotechnology and bioengineering. 113(4)

In vitro evolution of enzymes represents a powerful device to evolve new or to improve weak enzymatic functions. In the present work a semi-rational engineering approach has been used to design an efficient and thermostable organophosphate hydrolase,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::acf272a0e01878ec4bdfea5d81e374cd
https://pubmed.ncbi.nlm.nih.gov/26416557

Development of biological systems for the traceability of environmental pollutants

Autor: Immacolata Del Giudice, FIORENTINO, GABRIELLA, BARTOLUCCI, SIMONETTA

Arsenic is a natural trace element found in the environment in different oxidation states. Exposure to inorganic arsenic can cause various health effects with different severity, such as irritation of the stomach, intestine and cancer development. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::3bde16698d61c84e0de1a5d4cc888fb5
http://hdl.handle.net/11588/505928