Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure

Autor: Javier Fernández-Fernández, Concepción Gimeno, Maria Saumoy, María Eugenia Soria, Pau Gilabert, Gasshan Mereish, Helena Masnou-Ridaura, Federico Sáez-Royuela, Javier Salmerón, Raúl Rodríguez, Imma Ocaña, Juan Buenestado, José Francisco Macías-Sánchez, Xavier Forns, Elisabet Deig, Silvia Montoliu, José Castellote, Maria Isabel Costafreda, Ramiro Macenlle, Ildefonso Quiñones, David Tabernero, Jordi Niubó, Silvia Fábregas, Xavier Pamplona, Qian Chen, Maria Carlota Londoño, Juan Turnes, Mercè Barenys, Javier García-Samaniego, Agustín Albillos, Javier Crespo, Juan Manuel Pascasio, Joana Villaverde, B. Sacristan, Silvia Sauleda, Mar Riveiro-Barciela, Judit Carbonell, Silvia Salord, Oscar del Río, Leticia González-Moreno, Doroteo Acero-Fernández, Martín Prieto, A. Estebanez, Manolo Romero-Gómez, Arkaitz Imaz, Xavier Torras, María José López-de-Goicoechea, Jordi Navarro, Manuel Delgado-Blanco, Rosa Maria Morillas, Yolanda Real, Gemma Olivé, Rosa M Lopez, Salvador Augustin, Joan Carles Quer, Angels García-Flores, Nuria Margall, Leonardo Nieto-Aponte, Ángeles Castro-Iglesias, Ariadna Rando-Segura, Verónica Saludes, Rosa Durández, Elena Vargas-Accarino, Mireia Cairó, María Luisa García-Buey, Carme Mora-Moruny, Álvaro Mena-de-Cea, Paloma Sanz-Cameno, Lluis Castells, Miguel Miralbés, Francisco Suárez, Rosa Roca, Joaquín Cabezas, Carlos González-Portela, Albert Bernet, Pilar Castillo-Grau, Juan García-Costa, Mercedes Guerrero-Murillo, R. Quiles, Martin Bonacci, Juan Arenas, Juan Ignacio Esteban, Xavier Xiol, Silvia Viroles, Antonio Madejón, Sabela Lens, Maria Buti, María Silvan di Yacovo, Francisco Rodriguez-Frias, Manuel Rodríguez, Damir Garcia-Cehic, Esteban Domingo, Alejandra Otero, Elisa Martró, Manuel Hernández-Guerra, Inmaculada Fernández, Alba Cachero, Pilar Vázquez-Rodríguez, Carmen García-Martin, José A. Carrión, Miguel Angel Simón, Soledad López-Calvo, Gloria Sánchez-Antolín, Fernando Lázaro, J. Llaneras, Montserrat Forné, Meritxell Llorens-Revull, Maria Juana Gomez-Alonso, Francisco José Martínez-Cerezo, Isabel Conde, Maria Francesca Cortese, Silvia Blanch, Blau Camps, David Vieito, Sofía P. Ruzo, Moisés Diago, Marta Vila, Matilde Trigo-Daporta, Mercè Rosinach, Irati Fernandez-Alonso, Carme López-Núñez, María José Ferri, Georg von Massow, Jose Luis Calleja, Rafael Esteban, Sofía Pérez-del-Pulgar, Rafael Medina, Carme Baliellas, Ángeles Vázquez, Josep Quer, Mercè Roget, Angel Rubín, Celia Perales, Jose Antonio delCampo, María Dolores Ocete, T. Casanovas, J.J. Sanchez-Ruano, Lluís Force, A Martín-Cardona, R.J. Andrade, Angelina Cañizares, Víctor Vargas-Blasco, Marta Bes, Zoe Mariño, Josep Gregori, Raquel Baluja-Pino

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
RUC. Repositorio da Universidade da Coruña
ANTIVIRAL RESEARCH
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Antiviral Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
RUC: Repositorio da Universidade da Coruña
Universidade da Coruña (UDC)

[Abstract] A percentage of hepatitis C virus (HCV)-infected patients fail direct acting antiviral (DAA)-based treatment regimens, often because of drug resistance-associated substitutions (RAS). The aim of this study was to characterize the resistanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966f5d8ee50d2cf47275d0e6ef323c0f
http://zaguan.unizar.es/record/97128

Steady-State Pharmacokinetics of a Double-Boosting Regimen of Saquinavir Soft Gel plus Lopinavir plus Minidose Ritonavir in Human Immunodeficiency Virus-Infected Adults

Autor: Albert Pahissa, Lidia Ruiz, Rosa M Lopez, Vicenç Falcó, Manuel Crespo, Carlos Azuaje, Imma Ocaña, Marjorie Diaz, Bonaventura Clotet, I. Ruiz, Leonor Pou, Esteban Ribera

Publikováno v: Antimicrobial Agents and Chemotherapy. 48:4256-4262

AIDS-related morbidity and mortality have declined sharply with the use of potent antiretroviral regimens. Despite the clinical benefit observed with highly active antiretroviral therapy, inevitably most regimens fail; failure rates of 20 to 50% have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55725e55f4bd7fde7766730d98db30da
https://doi.org/10.1128/aac.48.11.4256-4262.2004

Tratamiento de las infecciones oportunistas en pacientes adultos y adolescentes infectados por el virus de la inmunodeficiencia humana en la era del tratamiento antirretrovírico de gran actividad

Autor: Jaime Locutura, Arturo Noguerado, José Ramón Costa, Carlos Barros, Fernando Dronda, Imma Ocaña, José Mallolas, Koldo Aguirrebengoa, Javier Ena, Joaquín Portilla, Antonio Guerrero, José López Aldeguer, Belén Padilla, Antonio Rivero, Jose R. Arribas, Rosa Blazquez, José Peña, Víctor Labrador Roca, Daniel Podzamczer, Santiago Moreno, Javier Juega, Félix Gutiérrez, Elisa Pérez-Cecilia, Ma Jesús Pérez Elías, Pablo Labarga, Federico Pulidod

Publikováno v: Enfermedades Infecciosas y Microbiología Clínica. 19:376-392

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::146d0d898b57e898c055d960f6f89c98
https://doi.org/10.1016/s0213-005x(01)72670-5

Improvements in subcutaneous fat, lipid profile, and parameters of mitochondrial toxicity in patients with peripheral lipoatrophy when stavudine is switched to tenofovir (LIPOTEST study)

Autor: Marjorie Diaz, Mercè Planas, Eva Castella, Adria Curran, Imma Ocaña, Esteban Ribera, Albert Pahissa, Sara Villar del Saz, Vicenç Falcó, José Carlos Paradiñeiro, Silvia Sauleda, Maria Feijoo, Elena García-Arumí, Manuel Crespo, C. Puiggros, Delia Sureda

Publikováno v: HIV clinical trials. 9(6)

Lipoatrophy is the most stigmatizing side effect of stavudine therapy. We assessed the long-term effects of replacing stavudine with tenofovir in HIV-infected patients with lipoatrophy.Prospective switch study. Sixty-two clinically stable patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afd79cfa366d64dc8d7aa2d89096bf8
https://pubmed.ncbi.nlm.nih.gov/19203906

Atazanavir and lopinavir/ritonavir: pharmacokinetics, safety and efficacy of a promising double-boosted protease inhibitor regimen

Autor: Leonor Pou, Imma Ocaña, Adria Curran, Albert Pahissa, Marjorie Diaz, Rosa M Lopez, Manuel Crespo, Carlos Azuaje, Maria Feijoo, Esteban Ribera

Publikováno v: AIDS (London, England). 20(8)

To assess the pharmacokinetics and tolerability of lopinavir (LPV), ritonavir (RTV) and atazanavir (ATV) as a double-boosted protease inhibitor regimen in HIV-infected adults.Sixteen patients who started LPV/RTV (400/100 mg b.i.d.) and ATV (300 mg q.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae3fa735d3a87ee5c58a3711dbd343e
https://pubmed.ncbi.nlm.nih.gov/16691064